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Volumn , Issue 10, 2001, Pages 1873-1881

Total synthesis of korormicin

Author keywords

Borates; Korormicin; Marine natural products; Nickel; Total synthesis

Indexed keywords

ALKENE; BORONIC ACID DERIVATIVE; KORORMICIN; LACTONE; NATURAL PRODUCT; NICKEL; UNCLASSIFIED DRUG;

EID: 0035037373     PISSN: 1434193X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-0690(200105)2001:10<1873::AID-EJOC1873>3.0.CO;2-O     Document Type: Article
Times cited : (35)

References (38)
  • 10
    • 20644440282 scopus 로고    scopus 로고
    • note
    • [8a] Preparation of 15 by another route shown below was also studied with racemic compounds. This route is shorter than that of Scheme 2, and preparation of (S)-ii by hydrogenation (Equation Presented) of (R)-iii is reported by Vlad.
  • 11
    • 20644451912 scopus 로고    scopus 로고
    • note
    • [8b] However, it was later found that (R)-iii is not available even though both the enantiomers of iii are found in the Merck Index.
  • 12
    • 20644438108 scopus 로고    scopus 로고
    • note
    • [8c] Major companies including Merck now produce it as a racemic form.
  • 14
    • 0003601534 scopus 로고    scopus 로고
    • Merck & Co., Inc., Whitehouse Station, NJ, Linalool
    • [8e] The Merck Index, 12th ed. (Ed.: S. Budavari), Merck & Co., Inc., Whitehouse Station, NJ, 1996, 5520 Linalool.
    • (1996) The Merck Index, 12th Ed. , pp. 5520
    • Budavari, S.1
  • 21
    • 20644466930 scopus 로고    scopus 로고
    • note
    • 3): δ= 175.0, 74.2, 72.9, 60.7, 33.3, 28.7, 20.0, 17.2, 14.1.
  • 22
    • 20644437407 scopus 로고    scopus 로고
    • note
    • 1H NMR spectroscopy of the derived MTPA ester.
  • 25
    • 20644434463 scopus 로고    scopus 로고
    • note
    • Alternatively, the following method afforded 15 in 17% yield from alcohol 13. (Equation Presented)
  • 30
    • 20644459590 scopus 로고    scopus 로고
    • note
    • 3) of 24: δ= 2.42 (dd, J = 13.5, 4 Hz, 1 H), 2.86 (dd, J = 13.5, 11 Hz, 1 H), 3.62-3.72 (m, 1 H), 4.07-4.24 (m, 1 H), 4.92-5.03 (m, 1 H), 6.25 (t, J = 8 Hz, 1 H), 6.35 (d, J = 8 Hz, 1 H).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.