Application of pressure-controlled colon delivery capsule to oral administration of glycyrrhizin in dogs

Journal of Pharmacy and Pharmacology

Volumn 53, Issue 4, 2001, Pages 441-447

  Shibata, N ^a   Ohno, T ^a   Shimokawa, T ^a   Hu, Z ^a   Yoshikawa, Y ^a   Koga, K ^b   Murakami, M ^a   Takada, K ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b HOKURIKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCYRRHIZIC ACID; INTESTINE ENZYME; LABRASOL; POLYSORBATE 80; PROPYLENE GLYCOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; COLON ABSORPTION; CONCENTRATION RESPONSE; CONTROLLED DRUG RELEASE; DOG; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG HYDROLYSIS; DRUG IDENTIFICATION; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRESSURE GRADIENT; SYSTEMIC CIRCULATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFECTIVE AGENTS; BIOLOGICAL AVAILABILITY; CAPSULES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLON; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; EXCIPIENTS; GLYCYRRHIZIC ACID; MALE; POLYSORBATES; PRESSURE; SURFACE-ACTIVE AGENTS;

EID: 0035037219     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357011775730     Document Type: Article

References (22)

1. Interferon induction by glycyrrhizin and glycyrrhetinic acid in mice
2. Amphiphilic vehicles improve the oral bioavailability of a poorly soluble HIV protease inhibitor at high doses
3. Lipid microemulsions for improving drug disposition and oral absorption: Physical and biopharmaceutical aspects
4. Gamma scintigraphy and neutron activation techniques in the in vivo assessment of orally administered dosage forms
5. Therapeutic effect of glycyrrheizin suppository on chronic active hepatitis, Shinnryo-to-shinyaku
6. Development and validation of a pig model for colon-specific drug delivery
7. Determination of urinary 18 β-glycyrrhetinic acids chromatography and its clinical application in man
8. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities
9. Stool water content and colonic drug absorption: Contrasting effects of lactulose and codeine
10. Characterization of norfloxacine release from tablet coated with a new pH-sensitive polymer, P-415F
11. Application of a biomagnetic measurement system (BMS) to the evaluation of gastrointestinal transits of intestinal pressure-controlled colon delivery capsules (PCDCs) in human subjects
12. Biotransformation of glycyrrhizin to 18 β-glycyrrhetic acid-3-o-β-D-glucuronide by Streptococcus LJ-22, a human intestinal bacterium
13. Determination of 18α-glycyrrhizin and 18β-glycyrrhizin in dog plasma by high-performance liquid chromatography
14. Macromolecular prodrugs. XVI. Colon-targeted delivery - Comparison of the rate of release of naproxen from dextran ester prodrugs in homogenates of various segments of the pig gastrointestinal (GI) tract
15. Gastroretentive dosage forms
16. Evaluation of intestinal pressure-controlled colon delivery capsule containing caffeine as a model drug in human volunteers
17. Enzyme immunoassay for glycyrrhetic acid and glycyrrhezin. 2. Measurement of glycyrrhetic acid and glycyrrhezin in blood
18. Targeting in the gastrointestinal tract: New approaches
19. Development of colon delivery capsule and the pharmacological activity of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in beagle dogs
20. Application of colon delivery capsule to 5-aminosalicylic acid and evaluation of the pharmacokinetic profile after oral administration to beagle dogs
21. Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats: Relevance to the intestinal bacterial hydrolysis
22. Glycyrrhizin as a potential treatment for chronic hepatitis C