Dimeric sesquiterpene thioalkaloids with potent immunosuppressive activity from the rhizome of Nuphar pumilum: Structural requirements of Nuphar alkaloids for immunosuppressive activity

Bioorganic and Medicinal Chemistry

Volumn 9, Issue 4, 2001, Pages 1031-1035

  Matsuda, Hisashi ^a   Shimoda, Hiroshi ^a   Yoshikawa, Masayuki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXYTHIOBINUPHARIDINE; 6,6 DIHYDROXYTHIOBINUPHARIDINE; 7 EPIDEOXYNUPHARIDINE; ALKALOID; DEOXYNUPHARIDINE; IMMUNOSUPPRESSIVE AGENT; NUPHAR PUMILUM EXTRACT; NUPHARIDINE; NUPHAROLURINE; PLANT EXTRACT; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG ISOLATION; FEMALE; IMMUNE RESPONSE; MOUSE; NONHUMAN; PLAQUE FORMING CELL; SHEEP ERYTHROCYTE; SPLEEN CELL; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANIMALS; CELL SURVIVAL; ERYTHROCYTES; FEMALE; IMMUNOSUPPRESSIVE AGENTS; METHANOL; MICE; MICE, INBRED C57BL; PLANT ROOTS; PLANTS, MEDICINAL; SESQUITERPENES; SHEEP; SOLVENTS; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035036122     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00327-8     Document Type: Article

References (17)

1. Arata Y., Ohashi Y. Yakugaku Zasshi. 77:1957;236.
2. Yoshikawa M., Murakami T., Ikebata A., Ishikado A., Murakami N., Yamahara J., Matsuda H. Chem. Pharm. Bull. 45:1997;756.
3. Yoshikawa M., Tomohiro N., Murakami T., Ikebata A., Matsuda H., Matsuda H., Kubo M. Chem. Pharm. Bull. 47:1999;524.
4. Matsuda H., Kageura T., Toguchida I., Murakami T., Kishi A., Yoshikawa M. Bioorg. Med. Chem. Lett. 9:1999;3081. and literatures cited therein.
5. Yoshikawa M., Murakami T., Wakao S., Ishikado A., Murakami N., Yamahara J., Matsuda H. Heterocycles. 45:1997;1815.
6. Yoshikawa M., Murakami T., Ishikado A., Wakao S., Murakami N., Yamahara J., Matsuda H. Heterocycles. 46:1997;301.
7. Suzuki Y., Hagiwara Y., Taguchi K., Kajiyama K., Ikeda T. Jpn. J. Pharmacol. 31:1981;391.
8. Robert I.M., Richard W.D. J. Exp. Med. 126:1967;423.
9. LaLonde R.T., Wong C.F., Das K.C. J. Am. Chem. Soc. 95:1973;6342.
10. LaLonde R.T., Wong C.F., Cullen W.P. Tetrahedron Lett. 51:1970;4477.
11. LaLonde R.T., Wong C.F., Das K.C. J. Org. Chem. 39:1974;2892.
12. LaLonde R.T., Wong C.F. Phytochemistry. 11:1972;3305.
13. Wong C.F., LaLonde R.T. Phytochemistry. 9:1970;659.
14. Wrobel J.T., Iwanow A., Danheux C.B., Martin T.I., Maclean D.B. Can. J. Chem. 50:1972;1831.
15. Martin T.I., Maclean D.B., Krishnamachari N., Calvo C. Can. J. Chem. 51:1973;2810.
16. Cunningham A.J. Nature. 207:1965;1106.
17. Ishiyama M., Shiga M., Sasamoto K., Mizoguchi M., He P. Chem. Pharm. Bull. 41:1993;1118.