Blockade of delta opioid receptors in the ventrolateral periaqueductal gray region inhibits the fall in arterial pressure evoked by hemorrhage

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 2, 2001, Pages 612-619

  Cavun, Sinan ^a   Resch, Garth E ^b   Evec, Adam D ^b   Rapacon Baker, Michelle M ^b   Millington, William R ^a  

^a ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DELTA OPIATE RECEPTOR; HOMOCYSTEIC ACID; NALOXONE; OPIATE RECEPTOR;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BLEEDING; CONTROLLED STUDY; DOSE RESPONSE; HYPOTENSION; MALE; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; SYMPATHETIC TONE; SYNAPTIC TRANSMISSION; THALAMUS VENTRAL NUCLEUS;

ANIMALS; BETA-ENDORPHIN; BLOOD PRESSURE; HEMORRHAGE; HOMOCYSTEINE; MALE; MICROINJECTIONS; NALOXONE; NALTREXONE; NARCOTIC ANTAGONISTS; PERIAQUEDUCTAL GRAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA;

EID: 0035035201     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Activation of spinal opioid receptors contributes to hypotension after hemorrhage in conscious rats
2. Brain mediation of active and passive emotional coping
3. The efferent projections of the periaqueductal gray in the rat: A Phaseolus vulgaris-leucoagglutinin study. II. Descending projections
4. Viscerotopic organization of neurons subserving hypotensive reactions within the midbrain periaqueductal grey: A correlative functional and anatomical study
5. Delta opioid receptors in the ventrolateral periaqueductal gray region mediate hemorrhagic hypotension
6. Extensive projections from the midbrain periaqueductal gray to the caudal ventrolateral medulla: A retrograde and anterograde tracing study in the rat
7. Common patterns of increased and decreased Fos expression in midbrain and pons evoked by noxious deep somatic and noxious visceral manipulations in the rat
8. Powerful depressor and sympathoinhibitory effects evoked from neurons in the caudal raphe pallidus and obscurus
9. Multiple opioid receptors in endotoxic shock: Evidence for δ involvement and μ-δ interactions in vivo
10. Binding affinity and selectivity of opioids at mu, delta and kappa receptors in monkey brain membranes
11. Opiate antagonists: A role in the treatment of hypovolemic shock
12. Central opioid receptors and baroreflex control of sympathetic and cardiovascular function
13. 3H]CTOP), a potent and highly selective peptide for mu opioid receptors in rat brain
14. The ventrolateral periaqueductal gray projects to caudal brainstem depressor regions: A functional-anatomical and physiological study
15. Delta opioid receptors in the caudal midline medulla mediate hypotension evoked by hemorrhage in the halothane anesthetized rat
16. Caudal midline medulla mediates behaviourally-coupled but not barorecepter-mediated vasodepression
17. Relationship of μ- and δ-opioid receptors to GABAergic neurons in the central nervous system, including antinociceptive brainstem circuits
18. Cardiovascular effects of microinjections of opioid agonists into the 'Depressor Region' of the ventrolateral periaqueductal gray region
19. Muscle pain activates a direct projection from ventrolateral periaqueductal gray to rostral ventrolateral medulla in rats
20. Anatomy of the CNS opioid systems
21. Integrated activity of cardiovascular and pain regulatory systems: Role in adaptive behavioural responses
22. 1-opioid receptor
23. Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain
24. Differential distribution of endomorphin 1- and endomarphin 2-like immunoreactivities in the CNS of the rodent
25. Differential cardiovascular and respiratory responses to central administration of selective opioid agonists in conscious rabbits: Correlation with receptor distribution
26. Biochemical and pharmacological characterization of multiple β-endorphinergic antinociceptive systems in the rat periaqueductal gray
27. Cardiovascular effects of opioid antagonist naloxone in rostral ventrolateral medulla of rabbits
28. β-Endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia
29. 30-31] attenuates hemorrhagic hypotension in conscious rats
30. Classification of opioid receptors
31. Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist
32. Brainstem enkephalinergic projections to spinal autonomic nuclei
33. μ and δ opioid synergy between the periaqueductal gray and the rostro-ventral medulla
34. Central opioid mechanisms and cardiovascular control in hemorrhagic hypotension
35. Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals
36. The mu opiate receptor is responsible for descending pain inhibition originating in the periaqueductal gray region of the rat brain
37. Microinjection of opiates into the periaqueductal gray matter attenuates neuropathic pain symptoms in rats
38. Different mechanisms mediate β-endorphin- and morphine-induced inhibition of the tail-flick response in rats
39. Pharmacology and mechanisms of opioid analgesic action