Potential treatment for clubfeet based on growth factor blockade

Journal of Pediatric Orthopaedics

Volumn 21, Issue 3, 2001, Pages 372-377

  Li, Catherine ^a   Nguyen, Quang ^b   Cole, William G ^a   Alman, Benjamin A ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Clubfoot; Platelet derived growth factor; Transforming growth factor

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; GROWTH FACTOR; NEUTRALIZING ANTIBODY; PLATELET DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA;

ADJUVANT THERAPY; ARTICLE; CELL PROLIFERATION; CHEMOTAXIS; CLUBFOOT; CONTROLLED STUDY; DUPUYTREN CONTRACTURE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MUSCLE STIFFNESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

CELLS, CULTURED; CHEMOTAXIS; CLUBFOOT; COLLAGEN; CONTRACTURE; PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, CELL SURFACE; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035028206     PISSN: 02716798     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004694-200105000-00021     Document Type: Article

References (32)

1. Regulation of proliferation and platelet-derived growth factor expression in palmar fibromatosis (Dupuytren contracture) by mechanical strain
2. Platelet-derived growth factor in fibrous musculoskeletal disorders: A study of pathologic tissue sections and in vitro primary cell cultures
3. Injury induces in vivo expression of PDGF and PDGF-receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts
4. The deletion of transforming growth factor-beta-induced myofibroblasts depends on growth conditions and actin organization
5. The role of transforming growth factor beta in Dupuytren's disease
6. The cell biology of transforming growth factor b
7. The embryologic origin of clubfoot
8. Transforming growth factor beta in tissue fibrosis
9. Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease
10. Randomised trial to assess safety fetal outcome of early midtrimester amniocentesis
11. Pathogenesis of Dupuytren's contracture. A correlative clinico-pathologic study
12. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells
13. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
14. Dupuytren contracture: Fibroblast contracture?
15. Differential collagen 1 gene expression in fetal fibroblasts
16. The pathological anatomy of idiopathic clubfoot
17. The muscles in clubfoot: A histologic, histochemical, and electron microscopic study
18. Long term results of treatment of congenital clubfoot
19. Genetic epidemiology study of idiopathic talipes equinovarus
20. Transforming growth factor-beta 2: cDNA cloning and sequence analysis
21. Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta 1
22. Platelet-derived growth factor-BB and transforming growth factor beta 1 selectively modulate glycosaminoglycans, collagen, and myofibroblasts in excisional wounds
23. Observations of pathogenesis and treatment of congenital clubfoot
24. Transforming growth factor-b stimulates wound healing and modulates extracellular matrix gene expression in pig skin
25. The biology of platelet derived growth factor
26. Pathogenesis of soft-tissue contracture in club foot
27. Identification of another member of the transforming growth factor type beta gene family
28. The expression of platelet-derived growth factor gene in Dupuytren contracture
29. Structure of a full-length cDNA clone for the prepro alpha 1(I) chain of human type I procollagen
30. Structural and functional aspects of platelet derived growth factor and its receptor
31. Presence of growth factors in palmar and plantar fibromatosis
32. An electron microscopic study of the fascia from the medial and lateral sides of clubfoot