In vitro melanin binding of NS-49, a phenethylamine class α1A-adrenoceptor agonist

Arzneimittel-Forschung/Drug Research

Volumn 51, Issue 4, 2001, Pages 299-303

  Yamada, T ^a   Okuyama, Y ^a   Mukai, H ^a  

^a NIPPON SHINYAKU CO LTD   (Japan)

Author keywords

(R) ( ) 3 (2 Amino 1 hydroxyethyl) 4 fluoromethanesulfonanilide hydrochloride; CAS 137431 04 0; Melanin, synthetic; NS 49, binding to melanin, dissociation from melanin

Indexed keywords

3' (2 AMINO 1 HYDROXYETHYL) 4' FLUOROMETHANESULFONANILIDE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; CHLOROQUINE; DIAZEPAM; MELANIN; NOREPHEDRINE; OFLOXACIN; PHENETHYLAMINE;

ADSORPTION; ARTICLE; BINDING AFFINITY; CALCULATION; CONCENTRATION RESPONSE; DISSOCIATION; DRUG BINDING; DRUG SYNTHESIS; EYE TOXICITY;

EID: 0035027969     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300041     Document Type: Article

References (7)

1. 1-adrenoceptors
2. 1-adrenoceptor subtypes
3. Identification of alphal-adrenoceptor subtypes in the human prostatic urethra
4. The melanin binding of drugs and its implications
5. The reaction of uveal pigment in vitro with polycyclic compounds
6. The affinity of drugs for melanin and the prediction of side effects
7. Affinity of T-3761 for ocular melanin, and intracular dynamics