The 'hook effect' on serum prolactin estimation in a patient with macroprolactinoma

Neurology India

Volumn 49, Issue 1, 2001, Pages 78-80

  Unnikrishnan, A G ^a   Rajaratnam, S ^a   Seshadri, M S ^a   Kanagasapabathy, A S ^a   Stephen, D C ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Hook effect; Immunoassay; Prolactin

Indexed keywords

ANTIBODY; ANTIGEN; BROMOCRIPTINE; PROLACTIN;

ADULT; AMNESIA; ANTIGEN BINDING; ARTICLE; CANCER RADIOTHERAPY; CANCER SIZE; CASE REPORT; CHEMOLUMINESCENCE; DECOMPRESSION SURGERY; DIFFERENTIAL DIAGNOSIS; DILUTION; DISEASE COURSE; DISEASE SEVERITY; ERECTILE DYSFUNCTION; FOLLOW UP; HAIR LOSS; HEADACHE; HEMIANOPIA; HORMONE DETERMINATION; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; HYPOPHYSIS TUMOR; IMMUNOASSAY; LABORATORY DIAGNOSIS; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL EXAMINATION; PROLACTIN BLOOD LEVEL; PROLACTINOMA; PTOSIS; TABLET; TREATMENT OUTCOME; TUMOR BIOPSY; VISION TEST; VISUAL ACUITY; VISUAL FIELD;

ADULT; ANTIGEN-ANTIBODY REACTIONS; HUMANS; IMMUNOASSAY; MALE; PITUITARY NEOPLASMS; PROLACTIN; PROLACTINOMA;

EID: 0035027662     PISSN: 00283886     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Immunoradiometric assays may miss high prolactin levels
2. Clinical laboratory methods for detection of antigens and antibodies
3. The hook effect: High concentrations of the prostrate specific antigen giving artefactually low values on one step immunoassay
4. High prolaction levels may be missed by immunoradiometric assay in patients with macroprolactinomas
5. Giant pituitary prolactionoma with falsely low serum prolactin: The pitfall of the 'High Dose Hook' effect: Case report
6. Brucella species