Functional reconstitution, membrane targeting, genomic structure, and chromosomal localization of a human urate transporter

Journal of Clinical Investigation

Volumn 107, Issue 9, 2001, Pages 1103-1115

  Lipkowitz, Michael S ^a   Leal Pinto, Edgar ^a   Rappoport, Joshua Z ^a   Najfeld, Vesna ^a   Abramson, Ruth G ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CELL PROTEIN; GALECTIN; ISOPROTEIN; MEMBRANE PROTEIN; URATE; URIC ACID;

ANIMAL CELL; ARTICLE; CARDIOVASCULAR DISEASE; CELL MEMBRANE TRANSPORT; CHROMOSOMAL LOCALIZATION; CHROMOSOME 17; CHROMOSOME MAP; CONTROLLED STUDY; EXON; GENE EXPRESSION; GENE STRUCTURE; GOUT; HOMEOSTASIS; HUMAN; HUMAN CELL; HYPERTENSION; HYPERURICEMIA; KIDNEY EPITHELIUM; KIDNEY FAILURE; LIPID BILAYER; MOLECULAR BIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; RISK FACTOR; SEQUENCE HOMOLOGY; URIC ACID URINE LEVEL;

EID: 0035024743     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI12471     Document Type: Article

References (68)

1. Biosynthesis of amino acids, nucleotide, and related molecules
2. Uricase
3. Peroxisomes (microbodies and related particles)
4. Microbodies and related particles. Morphology, biochemistry, and physiology
5. Urate oxidase: Primary structure and evolutionary implications
6. Two independent mutational events in the loss of urate oxidase during hominoid evolution
7. Evolution of the uric acid transport mechanisms in vertebrate kidney
8. 14-labeled uric acid. Uricolysis
9. Extrarenal disposal of uric acid
10. Urate uptake in membrane vesicles of rat renal cortex: Effect of copper
11. Carrier-mediated concentrative urate transport in rat renal membrane vesicles
12. Classical and channel-like urate transporters in rabbit renal brush border membranes
13. Urate transport in brush-border membrane of human kidney
14. pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles
15. Specificity and modes of the anion exchanger in dog renal microvillus membranes
16. Urate transport via anion exchange in dog renal microvillus membrane vesicles
17. Mechanism of urate and p-aminohippurate transport in rat renal microvillus membrane vesicles
18. Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes
19. Urate and p-aminohippurate transport in rat renal basolateral vesicles
20. Molecular cloning and functional reconstitution of a urate transporter/channel
21. Functional analysis and molecular modeling of a cloned urate transporter/channel
22. Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin
23. Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin
24. Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease
25. Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes
26. Requirement of divalent galactoside-binding activity of ecalectin/galectin-9 for eosinophil chemoattraction
27. An IgE-binding protein with a distinctive repetitive sequence and homology with an IgG receptor
28. Sequence of a full-length cDNA for rat lung betagalactoside-binding protein: Primary and secondary structure of the lectin
29. Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin
30. Soluble lactose-binding lectin from rat intestine with two different carbohydrate-binding domains in the same peptide chain
31. Galectins. Structure and function of a large family of animal lecrins
32. Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes
33. Galectin-8. A new rat lectin, related to galectin-4
34. Cloning, expression, and chromosome mapping of human galectin-7
35. Galectin-4 and galectin-6 are two closely related lectins expressed in mouse gastrointestinal tract
36. Single-step purification/solubilization of recombinant proteins: Application to surfactant protein B
37. Isolation and immunolocalization of a rat renal cortical membrane urate transporter
38. Biotinylation and assessment of membrane polarity: Caveats and methodological concerns
39. Two diverged human homeobox genes involved in the differentiation of human hemaropoietic progenitors map to chromosome 1, bands q41-42.1
40. Tyrosine-based membrane protein sorting signals are differentially interpreted by polarized Madin-Darby canine kidney and LLC-PK1 epihelial cells
41. Integral and peripheral protein composition of the apical and basolateral membrane domains in MDCK cells
42. Cellular localization and topology of a urate transporter/channel in mammalian cells
43. Galectins: A family of animal beta-galactosidebinding lectins
44. Secretion of the galectin family of mammalian carbohydrate-binding proteins
45. Renal function in gout. With a commentary on the renal regulation of urate excretion, and the role of the kidney in the pathogenesis of gout
46. Urate excretion in man, normal and gouty
47. Serum uric acid and related factors in 500 hospitalized subjects
48. Serum uric acid and hypertension: The Olivetti heart study
49. Relation between serum uric acid and blood pressure in adolescents
50. Hyperuricemia causes hypertension and renal disease via a novel crystal-independent mechanism
51. Familial juvenile gouty nephropathy with renal urate hypoexcretion preceding renal disease
52. Renal urate hypoexcretion preceding renal disease in a new kindred with familial juvenile gouty nephropathy (FJGN)
53. Autosomal dominant transmission of gouty arthritis with renal disease in a large Japanese family
54. Newly discovered familial juvenile gouty nephropathy in a Japanese family
55. Presymptomatic detection of familial juvenile hyperuricaemic nephropathy in children
56. Familial hyperuricemia and renal disease
57. Hereditary nephropathy associated with hyperuricemia and gour
58. Familial hyperuricemic nephropathy
59. Familial nephroparhy with hyperuricemia and gour
60. Hypertriglyceridaemia and hyperuricaemia are risk factors for progression of IgA nephropathy
61. Is thiazide-produced uric acid elevation harmful? Analysis of data from the Hypertension Detection and Follow-up Program
62. Hyperuricaemia and risk of cardiovascular disease and overall death. A 12-year follow-up of participants in the population study of women in Gothenburg, Sweden
63. Relation of serum uric acid to mortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study
64. Serum uric acid and cardiovascular events in successfully treated hypertensive patients
65. Reappraisal of the pathogenesis and consequences of hyperuricemia in hypertension, cardiovascular disease, and renal disease
66. Serum uric acid and risk for cardiovascular disease and death: The Framingham Heart Study
67. Is raised serum uric acid a cause of cardiovascular disease or death?
68. Much ado about nothing, or much to do about something? The continuing controversy over the role of uric acid in cardiovascular disease