Multiple functions of the nonconserved N-terminal domain of yeast TATA-binding protein

Genetics

Volumn 158, Issue 1, 2001, Pages 87-93

  Lee, Mark ^a,b   Struhl, Kevin ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; TATA BINDING PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL VIABILITY; COMPLEX FORMATION; DIMERIZATION; DNA TRANSCRIPTION; GENE DELETION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; YEAST;

DNA-BINDING PROTEINS; MODELS, MOLECULAR; MUTATION; PHENOTYPE; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; TATA BOX; TATA-BOX BINDING PROTEIN; TRANSCRIPTION FACTORS;

EID: 0035024076     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. TBP mutants defective in activated transcription in vivo
2. Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism
3. Molecular analysis of the SNF2/SWI2 protein family member MOT1, an ATP-driven enzyme that dissociates TATA-binding protein from DNA
4. Biochemistry and structural biology of transcription factor IID (TFIID)
5. Reevaluation of transcriptional regulation by TATA-binding protein oligomerization: Predominance of monomers
6. Crystal structure of yeast TATA-binding protein and model for interaction with DNA
7. Connecting a promoter-bound protein to the TATA-binding protein overrides the need for a transcriptional activation region
8. Dimerization of the TATA binding protein
9. The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters
10. NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global negative regulator of transcription that differentially affects TATA-element utilization
11. The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells
12. Regional codon randomization: Defining a TATA-binding protein surface required for RNA polymerase III transcription
13. Functional differences between yeast and human TFIID are localized to the highly conserved region
14. Conserved and nonconserved functions of yeast and human TATA-binding proteins
15. Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo
16. Isolation of STD1, a high-copy-number suppressor of a dominant negative mutation in the yeast TATA-binding protein
17. TATA-binding protein mutants that increase transcription from enhancerless and repressed promoters in vivo
18. A highly conserved domain of TFIID displays species specificity in vivo
19. Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae
20. TBP, a universal eukaryotic transcription factor?
21. Analysis of structure-function relationships of yeast TATA box binding factor TFIID
22. c TATA elements
23. Absolute mRNA levels and transcriptional initiation rates in Saccharomyces cerevisiae
24. A role for TBP dimerization in preventing unregulated gene expression
25. Multimerization of the mouse TATA-binding protein (TBP) driven by its C-terminal conserved domain
26. The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo
27. Genetic analysis of the Ydr1-Bur6 repressor complex reveals an intricate balance among transcriptional regulatory proteins in yeast
28. Effects of activation-defective TBP mutations on transcription initiation in yeast
29. Stimulation of RNA polymerase II transcription initiation by recruitment of TBP in vivo
30. Increased recruitment of TATA-binding protein to the promoter by transcriptional activation domains in vivo
31. The yeast TAF145 inhibitory domain and TFILA competitively bind to TATA-binding protein
32. Effect of the non-conserved N-terminus on the DNA binding activity of the yeast TATA binding protein
33. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme
34. TFIIA induces conformational changes in TFIID via interactions with the basic repeat
35. Mutations on the DNA-binding surface of TBP can specifically impair the response to acidic activators in vivo
36. A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo
37. The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo
38. The N-terminal domain of the human TATA-binding protein plays a role in transcription from TATA-containing RNA polymerase II and III promoters
39. Enhancement of TBP binding by activators and general transcription factors
40. Two distinct domains in the yeast transcription factor lid and evidence for a TATA box-induced conformational change
41. Evidence that Spt3 functionally interacts with Mot1, TFIIA, and TATA-binding protein to confer promoter-specific transcriptional control in Saccharomyces cerevisiae
42. Role for the amino-terminal region of human TBP in U6 snRNA transcription
43. TBP-associated factors are not generally required for transcriptional activation in yeast
44. Saccharomyces cerevisiae BUR6 encodes a DRAP1/NC2-alpha homolog that has both positive and negative roles in transcription in vivo
45. Dominant negative mutations in yeast TFIID define a bipartite DNA-binding region
46. The TBP-TFIIA interaction in the response to acidic activators in vivo
47. Duality of TBP, the universal transcription factor
48. STD1 (MSN3) interacts directly with the TATA-binding protein and modulates transcription of the SUC2 gene of Saccharomyces cerevisiae
49. Recruiting TATA-binding protein to a promoter: Transcriptional activation without an upstream activator
50. A single point mutation in TFIIA suppresses NC2 requirement in vivo
51. The yeast TATA-binding protein (TBP) core domain assembles with human TBP-associated factors into a functional TFIID complex
52. Requirement for acidic amino acid residues immediately N-terminal to the conserved domain of Saccharomyces cerevisiae TFIID