High-dose loratadine exposure in a six-year-old child

Veterinary and Human Toxicology

Volumn 43, Issue 3, 2001, Pages 163-164

  Cobb, Douglas B ^a   Watson, William A ^a   Fernández, Miguel C ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTAMINE H1 RECEPTOR ANTAGONIST; LORATADINE;

ALLERGIC RHINITIS; ARTICLE; CASE REPORT; DRUG MEGADOSE; DRUG OVERDOSE; FEMALE; HEART RATE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSION; LD 50; PRESCHOOL CHILD; TOXICITY TESTING; URTICARIA;

ANTI-ALLERGIC AGENTS; CHILD; FEMALE; HISTAMINE H1 ANTAGONISTS; HUMANS; LORATADINE; OVERDOSE; POISON CONTROL CENTERS; TREATMENT OUTCOME;

EID: 0035022791     PISSN: 01456296     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. rd Ed. Medical Economics Co, Montvale, NJ: 2825-2826, 1999.
2. Haria M, Fitton A, Peters DH: Loratadine: a reappraisal of its pharmacological properties and therapeutic use in allergic disorders. Drugs 48:617-637, 1994.
3. 1 antihistamines. Annals Allergy 67: 625-633, 1991.
4. rd Ed. WB Saunders Co, Philadelphia, PA: 647, 1998.
5. McEvoy GK: AHFS Drug Information, American Society of Health System Pharmacists, Bethesda, MD: 39, 2000.
6. 1-receptor antagonist drugs. New England Journal Medicine 330: 1663-1670, 1994.
7. Gaillard AK, Gruisen A, de Jong R: The influence of antihistamines on human performance. European Journal Clinical Pharmacology 35: 249-253, 1988.
8. 1-receptor antagonists. Clinical Experimental Allergy 26: 1092-1097, 1996.
9. Kay GG, Harris AG: Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clinical Experimental Allergy 29 Suppl 3: 147-150, 1999.
10. Delgado LF, Pferferman A, Sole D et al: Evaluation of the potential cardiotoxicity of the antihistamines terfenadine, astemizole, loratadine, and cetirizine in atopic children. Annals Allergy, Asthma Immunology 80: 333-337, 1998.
11. 1-antagonist, loratadine. European Journal Clinical Pharmacology 32: 419-421, 1987.
12. Roth T, Roehrs T, Koshored G et al: Sedative effects of antihistamines. Journal Allergy Clinical Immunology 80: 94-98, 1987.
13. Affrime MB, Lorber R, Danzeg M et al: Three month evaluation of electrocardiographic effects of loratadine in humans. Journal Allergy Clinical Immunology 91: 259, 1993 (abstract).
14. Luck JC, Evrard HM: Atrial fibrillation associated with loratadine use. Journal Allergy Clinical Immunology 95: 282, 1995 (abstract).
15. Good AP, Rockwood R, Schad P: Loratadine and ventricular tachycardia. American Journal Cardiology 74: 207, 1992 (letter).
16. Delpon E, Valenzuela C, Gay P et al: Block of human cardiac Kv1.5 channels by loratadine: voltage-, time-, and use-dependent block at concentrations above therapeutic levels. Cardiovascular Research 35: 341-350, 1997.
17. Woosley R, Darrow WR: Analysis of potential adverse drug reactions-a case of mistaken identity. American Journal of Cardiology 74: 208-209, 1994 (letter).
18. Vignogna-Barlas L, Caraccio TR, Mofenson HC: Clinical effects of acute loratadine exposure: a review of 71 cases. Journal Toxicology Clinical Toxicology 36: 439-440, 1998, (abstract).
19. Van Cauwenberge PB: New data on the safety of loratadine. Drug Investigations 4: 283-291, 1992.