Decreased glomerular expression of agrin in diabetic nephropathy and podocytes, cultured in high glucose medium

Experimental Nephrology

Volumn 9, Issue 3, 2001, Pages 214-222

  Yard, B A ^d   Kahlert, S ^e   Engelleiter, R ^e   Resch, S ^e   Waldherr, R ^a   Groffen, A J ^b   Van Den Heuvel, L P W J ^b   Van Der Born, J ^b   Berden, J H M ^b   Kroger S ^c   Hafner, M ^e   Van Der Woude, F J ^e  

^a Gemeinschaftspraxis fur Pathologie   (Germany)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e NONE

Author keywords

Agrin; Diabetic nephropathy; Heparan sulfate proteoglycans

Indexed keywords

AGRIN; CD31 ANTIGEN; COMPLEMENT COMPONENT C3B RECEPTOR; GLUCOSE; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; MONOCLONAL ANTIBODY; PROTEOHEPARAN SULFATE;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CULTURE MEDIUM; DIABETIC NEPHROPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS; FROZEN SECTION; GLOMERULUS; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; IMMUNOFLUORESCENCE; KIDNEY BIOPSY; MALE; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SULFATION;

EID: 0035021506     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: 10.1159/000052614     Document Type: Article

References (44)

1. Chang RLS, Ueki IF, Troy JL, Deen WM, Robertson CR, Brenner BM: Permselectivity of glomerular capillary wall to macromolecules. II. Experimental studies in rats using neutral dextran. Biophys J 1975;15:887-906.
2. Renke GR, Patel Y, Venkatachalam MA: Glomerular filtration of proteins: Clearance of anionic, neutral, and cationic horseradish peroxidase in rat. Kidney Int 1978;13:324-328.
3. Chang RLS, Deen WM, Robertson CR, Brenner BM: Permselectivity of the glomerular capillary wall. III. Restricted transport of polyanions. Kidney Int 1975;8:212-218.
4. Martin GR, Timpl R, Kuhn K: Basement membrane proteins: Molecular structure and function; in Anfinsen CB, Edsall JT, Richards FM, Eisenberg DS (eds): Advances in Protein Chemistry. San Diego, Academic Press, 1988, pp 1-150.
5. Kanwar YS, Linker A, Farquhar MG: Increased permeability of the glomerular basement membrane to ferritin after removal of glycosaminoglycans (hepatan sulfate) by enzyme digestion. J Cell Biol 1980;86:688-693.
6. Kanwar YS, Liu ZZ, Kashihara N, Wallner El: Current status of the structural and functional basis of glomerular filtration and proteinuria. Semin Nephrol 1991;11:390-413.
7. Murdoch AD, Liu B, Schwarting R, Tuan RS, Iozzo RV: Widespread expression of perlecan proteoglycan in basement membranes and extracellular matrices of human tissues as detected by a novel monoclonal antibody against domain III and by in situ hybridization. J Histochem Cytochem 1994;42:239-249.
8. Van den Born J, van den Heuvel LP, Bakker MA, Veerkamp JH, Assman KJ, Berden JH: Monoclonal antibodies against the protein core and glycosaminoglycan side chain of glomerular basement membrane heparan sulfate proteoglycan: Characterization and immunohistochemical application in human tissues. J Histochem Cytochem 1994;42:89-102.
9. Van den Heuvel LP, Westenend PJ, van den Born J, Assman KJ, Knoers N, Monnens LA: Aberrant proteoglycan composition of the glomerular basement membrane in a patient with Denys-Drash syndrome. Nephrol Dial Transplant 1995;10:2205-2211.
10. Couchman JR, Ljubimov AV, Sthanam M, Horchar T, Hassel JR: Antibody mapping and tissue localization of globular and cysteine-rich regions of perlecan domain III. J Histochem Cytochem 1995;43:955-963.
11. Groffen AJ, Ruegg MA, Dijkman H, Van de Velden TJ, Buskens CA, van den Born J, Assman KJ, Monnens LA, Veerkamp JH, van den Heuvel LP: Agrin is a major heparan sulfate proteoglycan in the human glomerular basement membrane. J Histochem Cytochem 1998; 46:1-9.
12. Denzer AJ, Gesemann M, Schumacher B, Ruegg MA: An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix. J Cell Biol 1995;131:1547-1560.
13. Denzer AJ, Brandenberger R, Gesemann M, Chiquet M, Ruegg MA: Agrin binds to nerve-muscle basal lamina via laminin. J Cell Biol 1997;137:671-683.
14. Dunclert A, Changeux JP: Acetylcholine receptor gene expression at the developing neuromuscular junction. Physiol Rev 1995;75:339-368.
15. Gesemann M, Denzer AJ, Rueg MA: Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site. J Cell Biol 1995;128:625-636.
16. Ferns M, Hoch W, Campanelli JT, Rupp F, Hall ZW, Scheller RH: RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes. Neuron 1992;8:1079-1086.
17. Ferns MJ, Campanelli JT, Hoch W, Scheller RH, Hall Z: The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans. Neuron 1993;11: 491-502.
18. Ruegg MA, Tsim KW, Horton SE, Kröger S, McMahan UJ: The agrin gene codes for a family of basal lamina proteins that differ in functions and distribution. Neuron 1992;8:691-699.
19. Thomas WS, O'Dowd DK, Smith MA: Development expression and alternative splicing of chick agrin RNA. Dev Biol 1993;158:523-535.
20. Hoch W, Ferns M, Campanelli JT, Hall ZW, Scheller RH: Developmental regulation of highly active alternatively spliced forms of agrin. Neuron 1993;11:479-490.
21. Ma E, Morgan R, Godfrey EW: Distribution of agrin messenger RNAs in the chick embryo nervous system. J Neurosci 1994;14:2943-2952.
22. Kashgarian M, Oshima S, Takeuchi A, Trockmorton D, Rasmussen H: The contribution of mesangial cell collagen synthesis to pathogenesis of diabetic nephropathy. Contrib Ncphrol. Basel, Karger, 1994, vol 107, pp 132-139.
23. Van den Born J, van den Heuvel LP, Bakker MA, Veerkamp JH, Assman KJ, Weening JJ, Berden JH: Distribution of GBM heparan sulfate proteoglycan core protein and side chains in human glomerular diseases. Kidney Int 1993;43:454-463.
24. Van Det NF, van den Born J, Tamsma JT, Verhagen NAM, Berden JHM, Bruijn JA, Daha MR, van der Woude FJ: Effects of high glucose on the production of heparan sulfate proteoglycan by mesangial and glomerular visceral epithelial cells. Kidney Int 1996;49:1079-1089.
25. Tamsma JT, van den Born J, Bruijn JA, Assmann KJM, Weening JJ, Berden JHM, Weislander J, Schrama E, Hermans J, Veerkamp JH, Lemkes HHPJ, van der Woude FJ: Expression of glomerular extracellular matrix components in human diabetic nephropathy: Decrease of heparan sulphate in the glomerular basement membrane. Diabetologia 1994;37: 313-320.
26. Van den Born J, van Kraats AA, Bakker MAH, Assmann KJM, Dijkman HBPM, van der Laak JAWM, Berden JHM: Reduction of heparan sulphate-associated anionic sites in the glomerular basement membrane of rats with streptozotocin-induced diabetic nephropathy. Diabetologia 1995;38:1169-1175.
27. Vernier RL, Steffes MW, Sissons-Ross S, Mauer M: Heparan sulfate proteoglycan in the glomerular basement membrane in type I diabetes mellitus. Kidney Int 1992;41:1070-1080.
28. Shimomura H, Spiro R: Studies on macromolecular components of human glomerular basement membrane and alterations in diabetes: Decreased levels of heparan sulfate proteoglycan and laminin. Diabetes 1987;36:374-381.
29. Deckert T, Feldt-Rasmussen B, Borch-Johnson K, Jensen T, Kofoed-Enevoldsen A: Albuminuria reflects widespread vascular damage. Diabetologia 1989;32:219-226.
30. Olson JL: Diabetes mellitus: in Heptinstall RH (ed): Pathology of the Kidney. Boston, Little, Brown, 1995, pp 1715-1763.
31. Kröger S, Horton SA, Honig LA: The developing avian retina expresses agrin isoforms during synaptogenesis. J Neurobiol 1996;29:165-182.
32. Striker GE, Striker LJ: Glomerular cell culture. Lab Invest 1985;53:122-131.
33. Van den Heuvel LP, van den Born J, van Velden TJ, Veerkamp JH, Monnens LA, Schröder CH, Berden JH: Isolation and partial characterization of heparan sulfate proteoglycan from the human glomerular basement membrane. Biochem J 1989;264:457-465.
34. Groffen AJ, Buskens CAF, van Kuppevelt TH, Veerkamp JH, Monnens LAH, van den Heuvel LPWJ: Primary structure and high expression of human argin in basement membranes of adult lung and kidney. Eur J Biochem 1998; 254:123-128.
35. Aviezer D, Hecht D, Safran M, Eisinger M, David G, Yayon A: Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis. Cell 1994;79:1005-1013.
36. Aviezer D, Levy E, Safran M, Svahn C, Buddecke E, Schmidt A, David G, Vlodavsky I, Yayon A: Differential structural requirements of heparin and heparan sulfate proteoglycans that promote binding of basic fibroblast growth factor to its receptor. J Biol Chem 1994;269: 114-121.
37. Kofoed-Enevoldsen A: Inhibition of glomerular glucosamyl N-deacetylase in diabetic rats. Kidney Int 1992;41:763-767.
38. Kofoed-Enevoldsen A, Noonan D, Deckert T: Diabetes mellitus induced inhibition of glucosaminyl N-deacetylase: Effect of short-term blood glucose control in rats. Diabetologia 1993;63:310-315.
39. Dixon J, Loftus SK, Galdwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ: Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1. Genomics 1995;26:239-244.
40. Kusche-Gullberg M, Eriksson I, Pikas DS, Kjellen L: Identification and expression of two heparan sulfate glucosamyl N-deacetylase/N-sulfotransferase genes. J Biol Chem 1998;273: 11902-11907.
41. Raats ICJ, Bakker MAH, Hoch W, Tamboer WPM, Groffen AJ, van den Heuvel LPWJ, Berden JHM, van den Born J: Differential expression of agrin in renal basement membranes as revealed by domain-specific antibodies. J Biol Chem 1998;273:17832-17838.
42. Van Det NF, Tamsma JT, van den Born J, Verhagen NAM, van den Heuvel LPWJ, Lowik CWGM, Berden JHM, Bruijn JA, Daha MR, van der Woude FJ: Differential effects of angiotensin II and transforming growth factor-β on the production of heparan sulfate proteoglycans by mesangial cells in vitro. J Am Soc Nephrol 1996;7:1015-1023.
43. Platt JL, LeBien TW, Michael AF: Stages of renal ontogenesis identified by monoclonal antibodies reactive with lymphohemopoietic differentiation antigens. J Exp Med 1983;157: 155-172.
44. Appay MD, Kazatchkine MD, Mounier T, Bariety J: Presence of C3b complement receptor (CR1) antigens in the glomerular basement membrane of human fetal kidneys. Nephrol Dial Transplant 1988;2:162-165.