Norepinephrine infusion during moderate-intensity exercise increases glucose production and uptake

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 5, 2001, Pages 2118-2124

  Kreisman, Stuart H ^a   Ah Mew, Nicholas ^a   Halter, Jeffrey B ^b   Vranic, Mladen ^c   Marliss, Errol B ^a,d  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN; NORADRENALIN; NORADRENALIN BITARTRATE;

ADULT; ARTICLE; BICYCLE ERGOMETER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXERCISE; GLUCONEOGENESIS; GLUCOSE TRANSPORT; HUMAN; HUMAN EXPERIMENT; MALE; METABOLIC CLEARANCE RATE; NORADRENALIN BLOOD LEVEL; NORADRENALIN RELEASE; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

ADULT; EXERCISE; GLUCOSE; HUMANS; LACTIC ACID; MALE; NOREPINEPHRINE; OXYGEN CONSUMPTION; PYRUVIC ACID;

EID: 0035021097     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.5.2118     Document Type: Article

References (53)

1. Nobin A, Falck B, Ingemansson S, Järhutl J, Resengren E. 1997 Organization and function of the sympathetic innervation of human liver. Acta Physiol Scand Suppl. 45:103-106.
2. Lindfeldt J, Balkan B, van Dijk G, Scheurink A, Ahren B, Steffens AB. 1993 Influence of peri-arterial hepatic denervation on the glycemic response to exercise in rats. J Auton Nerv Syst. 44:45-52.
3. Weirsma MM, Vissing J, Mikines KJ, Steffens AB, Galbo H. 1995 Effect of liver denervation on glucose production during running in guinea pigs. Am J Physiol. 268:R72-R77.
4. Kjaer M, Keiding S, Engfred K, et al. 1995 Glucose homeostasis during exercise in humans with a liver or kidney transplant. Am J Physiol Endocrinol Metab. 268:E636-E644.
5. Kjaer M, Engfred K, Fernandes A, Secher NH, Galbo H. 1993 Regulation of hepatic glucose production during exercise in humans: role of sympathoadrenergic activity. Am J Physiol Endocrinol Metab. 265:E275-E283.
6. Connolly CC, Steiner KE, Stevenson RW, et al. 1991 Regulation of glucose metabolism by norepinephrine in conscious dogs. Am J Physiol Endocrinol Metab. 261:E764-E772.
7. Sacca L, Morrone G, Cicala M, Corso G, Ungaro B. 1980 Influence of epinephrine, norepinephrine, and isoproterenol on glucose homeostasis in normal man. J Clin Endocrinol Metab. 50:680-684.
8. Stevenson RW, Steiner KE, Connolly CC, et al. 1991 Dose-related effects of epinephrine on glucose production in conscious dogs. Am J Physiol Endocrinol Metab. 260:E363-E370.
9. Silverberg AB, Suresh D, Shah M, Haymond W, Cryer PE. 1978 Norepinephrine: hormone and neurotransmitter in man. Am J Physiol Endocrinol Metab. 234:E252-E256.
10. Issekutz Jr B, Vranic M. 1980 Role of glucagon in regulation of glucose production in exercising dogs. Am J Physiol Endocrinol Metab. 238:E13-E20.
11. Wasserman DH, Lickley HLA, Vranic M. 1984 Interactions between glucagon and other counterregulatory hormones during normoglycemic and hypoglycemic exercise in dogs. J Clin Invest. 74:1404-1413.
12. Berger CM, Sharis PJ, Bracy DP, Lacy DB, Wasserman DH. 1994 Sensitivity of exercise-induced increase in hepatic glucose production to glucose supply and demand. Am J Physiol Endocrinol Metab. 267:E411-E421.
13. Jenkins AB, Chisholm DJ, James DE, Ho KY, Kraegen EW. 1985 Exercise-induced hepatic glucose output is precisely sensitive to the rate of systemic glucose supply. Metab Clin Exp. 34:431-436.
14. Jenkins AB, Furler SM, Chisholm DJ, Kraegen EW. 1986 Regulation of hepatic glucose output during exercise by circulating glucose and insulin in humans. Am J Physiol. 250:R411-R417.
15. Weirsma MM, Vissing J, Steffens AB, Galbo H. 1993 Effects of glucose infusion on hormone secretion and hepatic glucose production during heavy exercise. Am J Physiol. 265 R1333-R1338.
16. Marliss EB, Kreisman SH, Manzon A, Halter JB, Vranic M, Nessim SJ. 2000 Gender differences in glucoregulatory responses to intense exercise. J Appl Physiol. 88:457-466.
17. Sigal RJ, Fisher S, Halter JB, Vranic M, Marliss EB. 1996 The roles of catecholamines in glucoregulation in intense exercise as defined by the islet cell clamp technique. Diabetes. 45:148-156.
18. Sigal RJ, Fisher SJ, Manzon A, Morais JA, Halter JB, Vranic M, Marliss EB. 2000 Glucoregulation during and after intense exercise: effects of α-adrenergic blockade. Metab Clin Exp. 49:386-394.
19. Sigal RJ, Purdon C, Bilinski D, Vranic M, Halter JB, Marliss EB. 1994 Glucoregulation during and after intense exerdse: effects of beta- blockade. J Clin Endocrinol Metab. 78:359-366.
20. Kjaer M, Farrell PA, Christensen NJ, Galbo H. 1986 Increased epinephrine response and inaccurate glucoregulation in exercising athletes. J Appl Physiol. 61:1693-1700.
21. Calles J, Cunningham JJ, Nelson L, et al. 1983 Glucose turnover during recovery from intensive exercise. Diabetes. 32:734-738.
22. Manzon A, Fisher SJ, Morais JA, et al. 1998 Glucose infusion partially attenuates glucose production and increases uptake during intense exercise. J Appl Physiol. 85:511-524.
23. Kreisman SH, Ah Mew N, Arsenault M, et al. 2000 Epinephrine infusion during moderate intensity exercise increases glucose production and uptake. Am J Physiol. 278:E949-E957.
24. Howlett K, Febbraio M, Hargreaves M. 1999 Glucose production during strenuous exercise in humans: role of epinephrine. Am J Physiol Endocrinol Metab. 276:E1130-E1135.
25. Kreisman SH, Manzon A, Nessim SJ, et al. 2000 Glucoregulatory responses to intense exercise performed in the postprandial state. Am J Physiol. 278:E786-E793.
26. Fisher SJ, Shi ZQ, Lickley HLA, Efendic S, Vranic M, Giacca A. 1996 A moderate decline in specific activity does not lead to an underestimation of hepatic glucose production during a glucose clamp. Metab Clin Exp. 45:587-593.
27. Evans MI, Halter JB, Porte D. 1978 Comparison of double- and single-isotope enzymatic derivative methods for measuring catecholamines in plasma. Clin Chem. 28:764-770.
28. Radziuk J, Norwich KM, Vranic M. 1978 Experimental validation of measurements of glucose turnover in nonsteady state. Am J Physiol. 234:84-93.
29. Bradley DC, Steil GM, Bergman RN. 1995 OOPSEG: a data smoothing program for quantitation and isolation of random measurement error. Comput Methods Programs Biomed. 46:67-77.
30. 2peak in untrained humans. Am J Physiol Endocrinol Metab. 273:E348-E354.
31. Coker RH, Krishna MG, Lacy DB, Bracy DP, Wasserman DH. 1997 Role of hepatic alpha- and beta-adrenergic receptor stimulation on hepatic glucose production during heavy exercise. Am J Physiol Endocrinol Metab. 273:E831-E838.
32. Howlett K, Galbo H, Lorentsen J, et al. 1999 Effect of adrenaline on glucose kinetics during exercise in adrenalectomised humans. J Physiol (Lond). 519.3:911-921.
33. Axelrod J, Weinshilboum R. 1972 Catecholamines. N Engl J Med. 287:237-242.
34. Wasserman DH. 1995 Regulation of glucose fluxes during exercise in the postabsorptive state. Annu Rev Physiol. 57:191-218.
35. Sonne B, Mikines KJ, Richter EA, Christensen NJ, Galbo H. 1985 Role of liver nerves and adrenal medulla in glucose turnover of running rats. J Appl Physiol. 59:1640-1646.
36. Wasserman DH, Williams PE, Lacy BD, Bracy D, Cherrington AD. 1990 Hepatic nerves are not essential to the increase in hepatic glucose production during muscular work. Am J Physiol Endocrinol Metab. 259:E195-E203.
37. Hoelzer DR, Dalsky GP, Schwartz NS, et al. 1986 Epinephrine is not critical to prevention of hypoglycemia during exercise in humans. Am J Physiol Endocrinol Metab. 251:E104-E110.
38. Chu CA, Sindelar DK, Neal DW, Allen EJ, Donahue EP, Cherrington AD. 1998 Effect of a selective rise in sinusoidal norepinephrine on HGP is due to an increase in glycogenolysis. Am J Physiol Endocrinol Metab. E162-E171.
39. Coker RH, Krishna MG, Lacy BD, Allen EJ, Wasserman DH. 1997 Sympathetic drive to liver and nonhepatic splanchnic tissue during heavy exercise. J Appl Physiol. 82:1244-1249.
40. Miura H, Jungermann K, Gardemann A. 1993 Differential control by arterial and portaInoradrenaline of hepatic carbohydrate metabolism: evidence for an indirect hemodynamic mechanism. Hepatology. 18:1410-1415.
41. Lekas MC, Fisher SJ, El-Bahrani B, Van Delangeryt M, Vranic M, Qing Shi Z. 1999 Glucose uptake during centrally induced stress is insulin independent and enhanced by adrenergic blockade. J Appl Physiol. 87:722-731.
42. Hirsch IB, Marker JC, Smith LJ, Spina RJ, Parvin CA, Holloszy JO, Cryer PE. 1991 Insulin and glucagon in prevention of hypoglycemia during exercise in humans. Am J Physiol Endocrinol Metab. 260:E695-E704.
43. Wasserman DH, Spalding JA, Lacy DB, Colburn CA, Goldstein RE, Cherrington AD. 1989 Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work. Am J Physiol Endocrinol Metab. 257:E108-E117.
44. Lembo G, Brunella C, Rendina V, et al. 1994 Acute noradrenergic activation induces insulin resistance in human skeletal muscle. Am J Physiol Endocrinol Metab. 266:E242-E247.
45. Marangou AG, Alford FP, Ward G, et al. 1988 Hormonal effects of norepinephrine on acute glucose disposal in humans: a minimal model analysis. Metabolism. 37:885-891.
46. Clutter WE, Bier DM, Shah SD, Cryer PE. 1980 Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man. J Clin Invest. 66:94-101.
47. Rizza RA, Cryer PE, Haymond MW, Gerich JE. 1980 Adrenergic mechanisms for the effects of epinephrine on glucose production and clearance in man. J Clin Invest. 65:682-689.
48. Rizza RA, Haymond M, Cryer P, Gerich J. 1979 Differential effects of epinephrine on glucose production and disposal in man. Am J Physiol. 237:E356-E362.
49. Rashid S, Qing Shi Z, Niwa M, et al. 2000 B-Blockade, but not normoglycemia or hyperinsulinemia, markedly diminishes stress-induced hyperglycemia in diabetic dogs. Diabetes. 49:253-262.
50. Fanelli C, Calderone S, Epifano L, et al. 1993 Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans. J Clin Invest. 92:1617-1622.
51. Rattigan S, Dora KA, Colquhoun EQ, Clark MG. 1995 Inhibition of insulin- mediated glucose uptake in rat hindlimb by an α-adrenergic vascular effect. Am J Physiol Endocrinol Metab. 268:E305-E311.
52. Shimizu Y, Satoh S, Yano H, Minokoshi Y, Cushman SW, Shimazu SW. 1998 Effects of noradrenaline on the cell-surface glucose transporters in cultured brown adipocytes: novel mechanism for selective activation of GLUT1 glucose transporters. Biochem J. 330:397-403.
53. Barron JT, Bàràny M, Gu L, Parrillo JE. 1998 Metabolic fate of glucose in vascular smooth muscle during contraction induced by norepinephrine. J Mol Cell Cardiol. 30:709-719.