Inhibition of LPS-induced airway hyperresponsiveness and airway inflammation by LPS antagonists

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 280, Issue 4 24-4, 2001, Pages

  Schwartz, David A ^a,d   Christ, William J ^b   Kleeberger, Steven R ^c   Wohlford Lenane, Christine L ^a  

^a UNIVERSITY OF IOWA   (United States)

^b EISAI RESEARCH INSTITUTE   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Asthma; Endotoxin; Lipopolysaccharide; Lung inflammation

Indexed keywords

BLOCKING AGENT; ENDOTOXIN; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE ANTAGONIST; LIPOPOLYSACCHARIDE ANTAGONIST 1044; LIPOPOLYSACCHARIDE ANTAGONIST 1287; LIPOPOLYSACCHARIDE ANTAGONIST 975; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AIRWAY; AIRWAY CONSTRICTION; ARTICLE; ASTHMA; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG LAVAGE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

EID: 0035020291     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.280.4.l771     Document Type: Article

References (39)

1. Albelda S, Smith C, and Ward P. Adhesion molecules and inflammatory injury. FASEB J 8: 504-512, 1994.
2. Becker S, Soukup JM, Gilmour MI, and Devlin RB. Stimulation of human and rat alveolar macrophages by urban air particulates: effects on oxidant radical generation and cytokine production. Toxicol Appl Pharmacol 141: 637-648, 1996.
3. Birkhead G, Attaway N, Strunk R, Townsend M, and Teutsch S. Investigation of a cluster of deaths of adolescents from asthma: evidence implicating inadequate treatment and poor patient adherence with medications. J Allergy Clin Immunol 84: 484-491, 1989.
4. Bonner JC, Rice AB, Lindroos PM, O'Brien PO, Dreher KL, Rosas I, Alfaro-Moreno E, and Osornio-Vargas AR. Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City. Am J Respir Cell Mol Biol 19: 672-680, 1998.
5. Carlos T and Harlan J. Leukocyte-endothelial adhesion molecules. Blood 84: 2068-2101, 1994.
6. Castellan RM, Olenchock SA, Kinsely KB, and Hankinson JL. Inhaled endotoxin and decreased spirometric values: an exposure-response relation for cotton dust. N Engl J Med 317: 605-610, 1987.
7. Christ W, Hawkins L, Kawata T, Rossignol D, Kobayashi S, and Asano O. Anti-Endotoxin Compounds. Andover, MA: Eisai, 1998.
8. Christ W, Rossignol D, Kobayashi S, and Kawata T. Substituted Lipopolysaccharides Useful in the Treatment and Prevention of Endotoxemia. Andover, MA: Eisai, 1998.
9. Christ WJ, Asano O, Robidoux ALC, Perez M, Wang Y, Dubuc GR, Gavin WE, Hawkins LD, McGuinness PD, Mullarkey MA, Lewis MD, Kishi Y, Kawata T, Bristol JR, Rose JR, Rossignol DP, Kobayashi S, Hishinuma L, Kimura A, Asakawa N, Katayama K, and Yamatsu I. E5531, a pure endotoxin antagonist of high potency. Science 268: 80-83, 1995.
10. Clapp WD, Becker S, Quay J, Watt JL, Thorne PS, Frees KL, Zhang X, Lux CR, and Schwartz DA. Grain dust-induced airflow obstruction and inflammation of the lower respiratory tract. Am J Respir Crit Care Med 150: 611-617, 1994.
11. Creamer H, Hunter N, Bullock W, and Gabler W. Concurrent lipopolysaccharide enhances chemotactic response of human polymorphonuclear leukocytes to bacterial chemotaxin. Inflammation 15: 201-211, 1991.
12. Deetz DC, Jagielo PJ, Quinn TJ, Thorne PS, Bleuer SA, and Schwartz DA. The kinetics of grain dust-induced inflammation of the lower respiratory tract. Am J Respir Crit Care Med 155: 254-259, 1997.
13. DeLisser H and Albelda S. The function of cell adhesion molecules in lung inflammation: more questions than answers. Am J Respir Cell Mol Biol 19: 533-536, 1998.
14. Donham K, Haglind P, Peterson Y, Rylander R, and Belin L. Environmental and health studies of farm workers in Swedish swine confinement buildings. Br J Ind Med 46: 31-37, 1989.
15. Fisher L and van Belle G. Biostatistics: A Methodology for the Health Sciences. New York: Wiley, 1993.
16. Gavett S, Madison S, Stevens M, and Costa D. Residual oil fly ash amplifies allergic cytokines, airway responsiveness, and inflammation in mice. Am J Respir Crit Care Med 160: 1897-1904, 1999.
17. Hogg J and Doerschuk C. Leukocyte traffic in the lung. Annu Rev Physiol 57: 97-114, 1995.
18. Jagielo PJ, Quinn TJ, Qureshi N, and Schwartz DA. Grain dust-induced lung inflammation is reduced by Rhodobacter sphaeroides diphosphoryl lipid A. Am J Physiol Lung Cell Mol Physiol 274: L26-L31, 1998.
19. Jagielo PJ, Thorne PS, Watt JL, Frees KL, Quinn TJ, and Schwartz DA. Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects. Chest 110: 263-270, 1996.
20. Kennedy SM, Christiani DC, Eisen EA, Wegman DH, Greaves IA, Olenchock SA, Ye T-T, and Lu P-L. Cotton dust and endotoxin exposure-response relationships in cotton textile workers. Am Rev Respir Dis 135: 194-200, 1987.
21. Malik A and Lo S. Vascular endothelial adhesion molecules and tissue inflammation. Pharmacol Rev 48: 213-229, 1996.
22. McFadden ER and Warren EL. Observations on asthma mortality. Ann Intern Med 127: 142-147, 1997.
23. Michel O, Ginanni R, Duchateau J, Vertongen F, Le Bon B, and Sergysels R. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy 21: 441-448, 1991.
24. Michel O, Ginanni R, Le Bon B, Content J, Duchateau J, and Sergysels R. Inflammatory response to acute inhalation of endotoxin in asthmatic patients. Am Rev Respir Dis 146: 352-357, 1992.
25. Michel O, Kips J, Duchateua J, Vertongen F, Robert L, Collet H, Pauwels R, and Sergysels R. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 154: 1641-1646, 1996.
26. Qureshi N, Takayama K, and Kurtz R. Diphosphoryl lipid A obtained from the nontoxic lipopolysaccharide of Rhodopseudomonas sphaeroides is an endotoxin antagonist in mice. Infect Immun 59: 441-444, 1991.
27. Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, Mitchell H, McNiff-Mortimer K, Lynn H, Ownby D, and Malveux F. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med 336: 1356-1363, 1997.
28. Rylander R, Bake B, Fischer JJ, and Helander IM. Pulmonary function and symptoms after inhalation of endotoxin. Am Rev Respir Dis 140: 981-986, 1989.
29. Rylander R, Haglind P, and Lundholm M. Endotoxin in cotton dust and respiratory function decrement among cotton workers in an experimental cardroom. Am Rev Respir Dis 131: 209-213, 1985.
30. Schwartz DA, Donham KJ, Olenchock SA, Popendorf W, van Fossen DS, Burmeister LF, and Merchant JA. Determinants of longitudinal changes in spirometric functions among swine confinement operators and farmers. Am J Respir Crit Care Med 151: 47-53, 1995.
31. Schwartz DA, Thorne PS, Jagielo PJ, White GE, Bleuer SA, and Frees KL. Endotoxin responsiveness and grain dust-induced inflammation in the lower respiratory tract. Am J Physiol Lung Cell Mol Physiol 267: L609-L617, 1994.
32. Schwartz DA, Thorne PS, Yagla SJ, Burmeister LF, Olenchock SA, Watt JL, and Quinn TJ. The role of endotoxin in grain dust-induced lung disease. Am J Respir Crit Care Med 152: 603-608, 1995.
33. Schwarze J, Hamelmann E, Larsen G, and Gelfand EW. Whole body plethysmography (WBP) in mice detects airway sensitization through changes in lower airways function. J Allergy Clin Immunol 97: 293, 1996.
34. Snyderman R, Phillips J, and Mergenhagen S. Biological activity of complement in vivo. Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates. J Exp Med 134: 1131-1143, 1971.
35. Takayama K, Qureshi N, Beutler B, and Kirkland TN. Diphosphoryl lipid A from Rhodopseudomonas sphaeroides ATCC 17023 blocks induction of cachectin in macrophages by lipopolysaccharide. Infect Immun 57: 1336-1338, 1989.
36. Thelin A, Tegler O, and Rylander R. Lung reactions during poultry handling related to dust and bacterial endotoxin levels. Eur J Respir Dis 65: 266-271, 1984.
37. Wohlford-Lenane C, Deetz D, and Schwartz D. Cytokine gene expression after inhalation of corn dust. Am J Physiol Lung Cell Mol Physiol 276: L736-L743, 1999.
38. Zhiping W, Malmberg P, Larsson B-M, Larsson K, Larsson L, and Saraf A. Exposure to bacteria in swine-house dust and acute inflammatory reactions in humans. Am J Respir Crit Care Med 154: 1261-1266, 1996.
39. Zuckerman SH and Qureshi N. In vivo inhibition of lipopolysaccharide-induced lethality and tumor necrosis factor synthesis by Rhodobacter sphaeroides diphosphoryl lipid A is dependent on corticosterone induction. Infect Immun 60: 2581-2587, 1992.