Placental gene expression of 11β-hydroxysteroid dehydrogenase type II and 15-hydroxyprostaglandin dehydrogenase is decreased in patients with preeclampsia

Nieren- und Hochdruckkrankheiten

Volumn 30, Issue 5, 2001, Pages 205-207

  Schoof, E ^a,c   Girstl, M ^a   Frobenius, W ^b   Kirschbaum, M ^c   Dorr H G ^a   Rascher, W ^a   Dotsch J ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

11 hydroxysteroid dehydrogenase type II; 15 hydroxyprostaglandin dehydrogenase; Placental gene expression; Preeclampsia

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; CARBENOXOLONE; DEXAMETHASONE;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME INACTIVATION; FEMALE; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MEASUREMENT; PLACENTA; POLYMERASE CHAIN REACTION; PREECLAMPSIA; PROTEINURIA; TISSUE LEVEL;

EID: 0035019171     PISSN: 03005224     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Benediktsson R., R.S. Lindsay, J. Noble, J.R. Seckl, C.R. Edwards: Glucocorticoid exposure in utero: new model for adult hypertension. Lancet 341, 339-341 (1993).
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3. McCalla C.O., V.L. Nacharaju, D.O. Muneyyirci, S. Glasgow, J.G. Feldman: Placental 11-beta-hydroxysteroid dehydrogenase activity in normotensive and preeclamptic pregnancies. Steroids 63, 511-515 (1998).
4. Patel F.A., K. Sun, J.R. Challis: Local modulation by 11-beta-hydroxysteroid dehydrogenase of glucocorticoid effects on the activity of 15-hydroxyprostaglandin dehydrogenase in human chorion and placental trophoblast cells. J. Clin. Endocrinol. Metab. 84, 395-400 (1999).
5. Roberts J.M., C.W.G. Redman: Preeclampsia: more than pregnancy-induced hypertension. Lancet 341, 1447-1451 (1993).