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Volumn 77, Issue 2-3, 2001, Pages 167-175

Structure-function studies of human 5-alpha reductase type 2 using site directed mutagenesis

Author keywords

[No Author keywords available]

Indexed keywords

FINASTERIDE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE TYPE 1; STEROID 5ALPHA REDUCTASE TYPE 2; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 0035018644     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(01)00022-X     Document Type: Article
Times cited : (6)

References (11)
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    • Andersson, S.1    Bishop, R.W.2    Russell, D.W.3
  • 2
    • 0025303307 scopus 로고
    • Structural and biochemical properties of cloned and expressed human and rat steroid 5α-reductases
    • Andersson S., Russell D.W. Structural and biochemical properties of cloned and expressed human and rat steroid 5α-reductases. Proc. Natl. Acad. Sci. USA. 87:1990;3640-3644.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3640-3644
    • Andersson, S.1    Russell, D.W.2
  • 3
    • 0026055914 scopus 로고
    • Deletion of steroid 5α-reductase 2 gene in male pseudohermaphrotidism
    • Andersson S., Berman D.M., Jenkins E.P., Russell D.W. Deletion of steroid 5α-reductase 2 gene in male pseudohermaphrotidism. Nature. 354:1991;159-161.
    • (1991) Nature , vol.354 , pp. 159-161
    • Andersson, S.1    Berman, D.M.2    Jenkins, E.P.3    Russell, D.W.4
  • 4
    • 0031757991 scopus 로고    scopus 로고
    • Cloning, expression and characterisation of Rhesus Macaque types 1 and 2 5 alpha-reductase: Evidence for mechanism based inhibition by Finasteride
    • Ellsworth K.P., Azzolina B.A., Cimis G., Bull H.G., Harris G.S. Cloning, expression and characterisation of Rhesus Macaque types 1 and 2 5 alpha-reductase: Evidence for mechanism based inhibition by Finasteride. J. Steroid Biochem. Mol. Biol. 66:1998;271-279.
    • (1998) J. Steroid Biochem. Mol. Biol. , vol.66 , pp. 271-279
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  • 5
    • 0026723090 scopus 로고
    • Tissue distribution and kinetic characteristics of rat steroid 5α-reductase isozymes: Evidence for distinct physiological functions
    • Normington K., Russell D.W. Tissue distribution and kinetic characteristics of rat steroid 5α-reductase isozymes: Evidence for distinct physiological functions. J. Biol. Chem. 267:1992;19548-19554.
    • (1992) J. Biol. Chem. , vol.267 , pp. 19548-19554
    • Normington, K.1    Russell, D.W.2
  • 6
    • 0027248515 scopus 로고
    • Characterization of Chinese hamster ovary cell lines expressing human steroid 5α-reductase isozymes
    • Thigpen A.E., Cala K.M., Russell D.W. Characterization of Chinese hamster ovary cell lines expressing human steroid 5α-reductase isozymes. J. Biol. Chem. 268:1993;17404-17412.
    • (1993) J. Biol. Chem. , vol.268 , pp. 17404-17412
    • Thigpen, A.E.1    Cala, K.M.2    Russell, D.W.3
  • 7
    • 0026701781 scopus 로고
    • Four amino acid segment in steroid 5α-reductase 1 confers sensitivity to Finasteride, a competitive inhibitor
    • Thigpen A.E., Russell D.W. Four amino acid segment in steroid 5α-reductase 1 confers sensitivity to Finasteride, a competitive inhibitor. J. Biol. Chem. 267:1992;8577-8583.
    • (1992) J. Biol. Chem. , vol.267 , pp. 8577-8583
    • Thigpen, A.E.1    Russell, D.W.2
  • 9
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    • Purification of DNA fragments from lyophilised agarose gels
    • Benore-Parson M., Anders L. Purification of DNA fragments from lyophilised agarose gels. Nucleic Acid Res. 23:1995;4926-4927.
    • (1995) Nucleic Acid Res. , vol.23 , pp. 4926-4927
    • Benore-Parson, M.1    Anders, L.2
  • 10
    • 0029448521 scopus 로고
    • 5-alpha reductase activity in cultured epithelial and stromal cells from normal and hyperplastic human prostates-effect of Finasteride (Proscar) a 5-alpha reductase inhibitor
    • Boudon C., Lobaccaro J.M., Lumbroso S., Lechevallier E., Mottet N., Gibelin B., Sultan C. 5-alpha reductase activity in cultured epithelial and stromal cells from normal and hyperplastic human prostates-effect of Finasteride (Proscar) a 5-alpha reductase inhibitor. Cell. Mol. Biol. 41:1995;1007-1015.
    • (1995) Cell. Mol. Biol. , vol.41 , pp. 1007-1015
    • Boudon, C.1    Lobaccaro, J.M.2    Lumbroso, S.3    Lechevallier, E.4    Mottet, N.5    Gibelin, B.6    Sultan, C.7
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    • Transient production of proteins using an adenovirus transformed cell line
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.