Influence of naloxone on the increased sensitivity to propofol during hypovolemia in the rat

Critical Care Medicine

Volumn 29, Issue 5, 2001, Pages 997-999

  De Paepe, Peter ^a   Van Sassenbroeck, Diederik K ^a   Belpaire, Frans M ^a   Buylaert, Walter A ^b  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Anesthesia; Effect site; Endogenous opioids; Hemorrhage; Hypovolemia; Naloxone; Pharmacodynamics; Propofol; Rat; Shock

Indexed keywords

NALOXONE; PROPOFOL; SODIUM CHLORIDE;

ANESTHESIA LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG SENSITIVITY; ELECTROENCEPHALOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOVOLEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RIGHTING REFLEX;

EID: 0035018161     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200105000-00023     Document Type: Article

References (14)

1. Kinetics of drug action in disease states. XXIII: Effect of acute hypovolemia on the pharmacodynamics of phenobarbital in rats
2. Kinetics of drug action in disease states. XXV: Effect of experimental hypovolemia on the pharmacodynamics and pharmacokinetics of desmethyldiazepam
3. Influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of etomidate in the rat
4. The influence of hypovolemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat
5. Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals
6. Differential effects of hemorrhage and LPS on tissue TNF-α, IL-1 and associate neuro-humoral and opioid alterations
7. Pre- and postsynaptic inhibition by opioids in rat striatum
8. A receptor-mediated inhibition
9. Improved method for the determination of propofol in blood by high-performance liquid chromatography with fluorescence detection
10. Kinetics of drug action in disease states. XXXV: Effect of hypovolemia on the pharmacodynamics of zoxazolamine in rats
11. Pharmacology of opioids
12. Pharmacokinetics of naloxone in rats and in man
13. 14C]naloxone in the rat and some comparative observations on nalorphine
14. Effects of anesthetics on regional hemodynamics in normovolemic and hemorrhaged rats