The Src signaling pathway regulates osteoclast lysosomal enzyme secretion and is rapidly modulated by estrogen

Journal of Bone and Mineral Research

Volumn 16, Issue 6, 2001, Pages 1028-1036

  Pascoe, David ^a   Oursler, Merry J O ^a  

^a UNIVERSITY OF MINNESOTA DULUTH   (United States)

Author keywords

Estrogen; Lysosomal enzymes; Osteoclast; Src; Tyrosine kinase

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CATHEPSIN B; CATHEPSIN K; ESTRADIOL; ESTROGEN; LYSOSOME ENZYME; PROTEIN C RAS; PROTEIN KINASE P60; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHICKEN; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; ENZYME RELEASE; FEMALE; HORMONAL REGULATION; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PROTEIN EXPRESSION;

EID: 0035018126     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.6.1028     Document Type: Article

References (5)

1. Roodman GD 1999 Cell biology of the osteoclast. Exp Hematol 27:1229-1241.
2. Baron R, Neff L, Louvard D, Courtoy PJ 1985 Cell-mediated extracellular acidification and bone resorption: Evidence for a low pH in resorbing lacunae and localization of a 100-kDa lysosomal membrane protein at the osteoclast ruffled border. J Cell Biol 101:2210-2222.
3. Soriano P, Montgomery C, Geske R, Bradley A 1991 Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64:693-702.
4. Boyce BF, Yoneda T, Lowe C, Soriano P, Mundy GR 1992 Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice. J Clin Invest 90:1622-1627.
5. Lowe C, Yoneda T, Boyce BF, Chen H, Mundy GR, Soriano P 1993 Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts. Proc Natl Acad Sci USA 90:4485-4489.