Effect of intratumoral OK-432 administration on thymidine phosphorylase expression in human gastric carcinoma

Anticancer Research

Volumn 21, Issue 2 B, 2001, Pages 1257-1262

  Ogawa, K ^a   Konno, S I ^a   Takebayashi, Y ^a   Murayama, M ^a   Shimakawa, T ^a   Katsube, T ^a   Naritaka, Y ^a   Kajiwara, T ^a   Aiba, M ^a   Akiyama, S ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Cytokine; Gastric carcinoma; OK 432; Thymidine phosphorylase

Indexed keywords

ALPHA INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1ALPHA; PICIBANIL; THYMIDINE PHOSPHORYLASE;

ADULT; ANGIOGENESIS; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG EFFECT; ENDOSCOPY; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; GASTRECTOMY; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CARCINOMA;

ANTINEOPLASTIC AGENTS; CAPILLARIES; FEMALE; HUMANS; INTERFERON TYPE II; INTERFERON-ALPHA; INTERLEUKIN-1; MALE; MIDDLE AGED; PICIBANIL; STOMACH NEOPLASMS; THYMIDINE PHOSPHORYLASE;

EID: 0035017814     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Kinetic studies of thymidine phosphorylase from mouse liver
2. The enzymatic synthesis of nucleosides. Thymidine phosphorylase in mammalian tissue
3. Purine nucleoside synthesis, an efficient method employing nucleoside phosphorylase
4. Role of uridine phosphorylase for antitumor activity of 5′-deoxy-5-fluoropyrimidine
5. Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites
6. Thymidine phosphorylase mediates the sensitivity of human colon carcinoma cells to 5-fluorouracil
7. Increased sensitivity to the prodrug 5′-deoxy-5-fluorouridine and modulation of 5-fluoro-2′-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase
8. Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors
9. The expression of thymidine phosphorylase and thrombo-modulin in human colorectal carcinomas
10. Expression of thymidine phosphorylase in human gastric carcinoma
11. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor
12. Angiogenic factor
13. Angiogenic activity of enzymes
14. 2, with 5′-deoxy 5 fluorouridine in colorectal cancer cells in vitro
15. Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5′-deoxy 5 fluorouridine
16. The correlation of thymidine phosphorylase activity with the expression of interleukin 1α, interferon ct and interferon γ in human colorectal carcinoma
17. Induction of interferon-γ in mouse spleen cells by OK-432, a preparation of streptococcus pyogenes
18. Augmentation of interleulin 1 and interleulin 2 production by OK-432
19. Release of tumor necrosis factor (TNF) into mouse peritoneal fluids by OK-432, a streptococcal preparation
20. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding
21. A comparative study of the peroxidase method and an Avidin-Biotin complex method for studying polypeptide hormones with radioimmunoassay antibody
22. The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium and endothelium
23. The concept of immunochemotherapy in gastric cancer
24. Studies on the effects of oral administration of OK-432 as postoperative adjuvant therapy
25. Intratumoral injection of a streptococcal preparation, OK-432, before surgery for gastric cancer
26. The effects of intratumoral OK-432 injection in gastric cancer patients
27. Increase in T cell infiltration in carcinoma tissue and regional lymph node reaction to gastric cancer after local injection of immunomodulators before gastrectomy