Peroxisomal targeting of mammalian hydroxyacid oxidase 1 requires the C-terminal tripeptide SKI

Journal of Cell Science

Volumn 114, Issue 9, 2001, Pages 1625-1629

  Recalcati, Stefania ^a,b   Menotti, Eric ^a   Kühn, Lukas C ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Glycolate oxidase; Hydroxyacid oxidase 1; Peroxisome; Protein import; Targeting signal

Indexed keywords

(S) 2 HYDROXY ACID OXIDASE; CELL PROTEIN; CELL RECEPTOR; COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; TRIPEPTIDE;

AMINO ACID SEQUENCE; ANALYSIS; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CLONING VECTOR; GENETIC TRANSFECTION; MAMMAL; MOLECULAR CLONING; MOLECULAR RECOGNITION; MONKEY; MOUSE; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PEROXISOME; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ALCOHOL OXIDOREDUCTASES; ANIMALS; BASE SEQUENCE; COS CELLS; DNA PRIMERS; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEROXISOMES; RECOMBINANT FUSION PROTEINS; SUBCELLULAR FRACTIONS;

ANIMALIA; MAMMALIA;

EID: 0035017656     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Angermuller, S., Leupold, C., Völkl, A. and Fahimi, H. D. (1986). Electron microscopic cytochemical localization of α-hydroxyacid oxidase in rat liver. Association with the crystalline core and matrix of peroxisomes. Histochemistry 85, 403-409.
2. Aitchison, J. D., Nuttley, W. M., Szilard, R. K., Brade, A. M., Glover, J. R. and Rachubinski, R. A. (1992). Peroxisome biogenesis in yeast. Mol. Microbiol. 6, 3455-3460.
3. Braverman, N., Steel, G., Obie, C., Moser, A., Moser, H., Gould, S. J. and Valle, D. (1997). Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata. Nat. Genet. 15, 369-376.
4. Dodt, G., Braverman, N., Wong, C., Moser, A., Moser, H. W., Watkins, P., Valle, D. and Gould, S. J. (1995). Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders. Nat. Genet. 9, 115-124.
5. Elgersma, Y. and Tabak, H. F. (1996). Proteins involved in peroxisome biogenesis and functioning. Biochim. Biophys. Acta. 1286, 269-283.
6. Fransen, M., Brees, C., Baumgart, E., Vanhooren, J. C. T., Baes, M., Mannaerts, G. P. and Van Veldhoven, P. P. (1995). Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor. J. Biol. Chem. 270, 7731-7736.
7. Gould, S. J., Keller, G.-A. and Subramani, S. (1987). Identification of a peroxisomal targeting signal at the carboxy terminus of firefly luciferase. J. Cell Biol. 105, 2923-2931.
8. Gould, S. J., Keller, G.-A., Hosken, N., Wilkinson, J. and Subramani, S. (1989). A conserved tripeptide sorts proteins to peroxisomes. J. Cell Biol. 108, 1657-1664.
9. Graham, F. L. and Van der Eb, A. J. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.
10. Kohler, S. A., Menotti, E. and Kühn, L. C. (1999). Molecular cloning of mouse glycolate oxidase: high evolutionary conservation and presence of an iron responsive element-like sequence in the mRNA. J. Biol. Chem. 274, 2401-2407.