The role of the liver in the acute effect of alcohol on androgens in women

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 5, 2001, Pages 1981-1985

  Sarkola, Taisto ^a   Adlercreutz, Herman ^b   Heinonen, Satu ^b   Von Der Pahlen, Bettina ^a   Eriksson, C J Peter ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ANDROGEN; ANDROSTENEDIONE; ETIOCHOLANOLONE; ORAL CONTRACEPTIVE AGENT; TESTOSTERONE;

ADULT; ALCOHOL CONSUMPTION; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; LIVER; ORAL CONTRACEPTION; PREMENOPAUSE; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL;

EID: 0035017491     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.86.5.7486     Document Type: Article

References (32)

1. Adler RA. 1992 Clinically important effects of alcohol on endocrine function. J Clin Endocrinol Metab. 74:957-960.
2. Hugues JN, Coste T, Perret G, Jayle MF, Sebaoun J, Modigliani E. 1980 Hypothalamo-pituitary ovarian function in thirty-one women with chronic alcoholism. Clin Endocrinol (Oxf). 12:543-551.
3. Van Thiel DH, Lester R. 1979 The effect of chronic alcohol abuse on sexual function. Clin Endocrinol Metab. 8:499-510.
4. Ylikahri R, Huttunen M, Härkönen M, et al. 1974 Low plasma testosterone values in men during hangover. J Steroid Biochem. 5:655-658.
5. Mendelson JH, Mello NK, Ellingboe J. 1977 Effects of acute alcohol intake on pituitary-gonadal hormones in normal human males. J Pharmacol Exp Ther. 202:676-682.
6. Välimäki M, Tuominen JA, Huhtaniemi I, Ylikahri R. 1990 The pulsatile secretion of gonadotropins and growth hormone, and the biological activity of luteinizing hormone in men acutely intoxicated with ethanol. Alcohol Clin Exp Res. 14:928-931.
7. Van Thiel DH, Lester R, Vaitukaitis J. 1978 Evidence for a defect in pituitary secretion of luteinizing hormone in chronic alcoholic men. J Clin Endocrinol Metab. 47:499-507.
8. Cicero TJ, Bell RD. 1980 Effects of ethanol and acetaldehyde on the biosynthesis of testosterone in the rodent testes. Biochem Biophys Res Commun. 94:814-819.
9. Orpana AK, Orava MM, Vihko RK, Härkönen M, Eriksson CJP. 1990 Role of ethanol metabolism in the inhibition of testosterone biosynthesis in rats in vivo: importance of gonadotropin stimulation. J Steroid Biochem Mol Biol. 37:273-278.
10. Eriksson CJP, Fukunaga T, Lindman R. 1994 Sex hormone response to alcohol. Nature. 369:711.
11. Sarkola T, Mäkisalo H, Fukunaga T, Eriksson CJP. 2000 Acute effect of alcohol on androgens in premenopausal women. Alcohol Alcoholism, 35:84-90.
12. Pettersson P, Ellsinger BM, Sjöberg C. 1990 Fat distribution and steroid hormones in women with alcohol abuse. J Intern Med. 228:311-316.
13. Välimäki M, Pelkonen R, Härkönen M, et al. 1990 Pituitary-gonadal hormones and adrenal androgens in non-cirrhotic female alcoholics after cessation of alcohol intake. Eur J Clin Invest. 20:177-181.
14. Dorgan JF, Reichman ME, Judd JT, et al. 1994 The relation of reported alcohol ingestion to plasma levels of estrogens and androgens in premenopausal women (Maryland, United States). Cancer Causes Control. 5:53-60.
15. Välimäki M, Laitinen K, Tiitinen A, et al. 1995 Gonadal function and morphology in non-cirrhotic female alcoholics: a controlled study with hormone measurements and ultrasonography. Acta Obstet Gynecol Scand. 74:462-466.
16. Cigolini M, Targher G, Bergamo Andreis JA, et al. 1996 Moderate alcohol consumption and its relation to visceral fat and plasma androgens in healthy women. Int J Obesity. 20:206-212.
17. Mendelson JH, Lukas SE, Mello NK, Amass L, Ellingboe J, Skupny A, 1988 Acute alcohol effects on plasma estradiol levels in women. Psychopharmacology. 94:464-467.
18. Sarkola T, Mäkisalo H, Fukunaga T, Eriksson CJP. 1999 Acute effect of alcohol on estradiol, estrone, progesterone, prolactin, cortisol, and luteinizing hormone in premenopausal women. Alcohol Clin Exp Res. 23:976-982.
19. Ginsburg ES, Mello NK, Mendelson JH, et al. 1996 Effects of alcohol ingestion on estrogens in postmenopausal women. JAMA. 276:1747-1751.
20. Hämäläinen E, Fotsis T, Adlercreutz H. 1991 A gas chromatographic method for the determination of neutral steroid profiles in urine, including studies on the effect of oxytetracycline administration on these profiles in men. Clin Chim Acta. 199:205-220.
21. Yen SC. 1999 Physiology of androgens in women. In; Yen SC, Jaffe RB, Barbieri RL, eds. Reproductive endocrinology: physiology, pathophysiology, and clinical management, 4th Ed. Philadelphia: Saunders; 481-486.
22. Forsander OA. 1970 Influence of ethanol on the redox state of the liver. Q J Studies Alcohol. 31:550-570.
23. Brent J, McMartin K, Phillips S, et al. 1999 Fomepizole for the treatment of ethylene glycol poisoning. N Engl J Med. 340:832-838.
24. Blomstrand R, Theorell H. 1970 Inhibitory effect on ethanol oxidation in man after administration of 4-methylpyrazole. Life Sci. 9:631-640.
25. Ehrig T, Bosron W, Li TK, 1990 Alcohol and aldehyde dehydrogenase. Alcohol Alcoholism, 25:105-116.
26. O'Malley BW, Strott CA. 1999 Steroid hormones: metabolism and mechanism of action. In: Yen SC, Jaffe RB, Barbieri RL, eds. Reproductive endocrinology: physiology, pathophysiology and clinical management, 4th Ed. Philadelphia: Saunders; 110-133.
27. Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S. 1993 Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20α-hydroxysteroid dehydrogenase activity. J Biol Chem. 268:12964-12969.
28. Casey ML, MacDonald PC, Andersson S. 1994 17β-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium. J Clin Invest. 94:2135-2141.
29. Clark BB, Morrissey RW, Fazekas JF, Welch CS. 1941 The role of insulin and the liver in alcohol metabolism. Q J Stud Alcohol. 1:663-683.
30. Andersson S, Cronholm T, Sjövall J. 1986 Redox effects of ethanol on steroid metabolism. Alcohol Clin Exp Res. 10(Suppl):55S-63S.
31. Tseng L, Gurpide E. 1979 Stimulation of various 17β- and 20α-hydroxysteroid dehydrogenase activities by progestins in human endometrium. Endocrinology. 104:1745-1748.
32. Sarkola T, Ahola L, von der Pahlen B, Eriksson CJP. 2001 Lack of effect of alcohol on ethinylestradiol in premenopausal women. Contraception. 63:19-23.