Living and training in moderate hypoxia does not improve V̇o2 max more than living and training in normoxia

Journal of Applied Physiology

Volumn 90, Issue 6, 2001, Pages 2057-2062

  Henderson, Kyle K ^a   Clancy, Richard L ^a   Gonzalez, Norberto C ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Exercise training; Hypoxic exercise; Hypoxic pulmonary hypertension; Hypoxic pulmonary vasoconstriction; Maximal exercise capacity; Maximal O2 uptake; Systemic O2 transport; Tissue O2 delivery; Tissue O2 extraction

Indexed keywords

ACCLIMATIZATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; EXERCISE; EXTRACTION; HEART OUTPUT; HEART RATE; HYPOTHESIS; HYPOXIA; LUNG ARTERY PRESSURE; MUSCLE CONTRACTION; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN DELIVERY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; TISSUE BLOOD FLOW; TRAINING;

EID: 0035016736     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2001.90.6.2057     Document Type: Article

References (27)

1. Bender PR, Groves BM, McCullough RE, McCullough RG, Trad L, Young AJ, Cymerman A, and Reeves JT. Decreased exercise muscle lactate release after high altitude acclimatization. J Appl Physiol 67: 1456-1462, 1989.
2. Buick FJ, Gledhill N, Froese AB, Spriet L, and Meyers EC. Effect of induced erythrocythemia on aerobic work capacity. J Appl Physiol 48: 636-642, 1980.
3. Cerretelli P. Limiting factors to oxygen transport on Mount Everest. J Appl Physiol 40: 658-667, 1976.
4. Charlton GA and Crawford MH. Physiologic consequences of training. Cardiol Clin 15: 345-354, 1997.
5. Gledhill N. The influence of altered blood volume and oxygen transport capacity on aerobic performance. Exerc Sport Sci Rev 13: 75-93, 1985.
6. 2 uptake in rats acclimatized to simulated altitude. J Appl Physiol 84: 164-168, 1998.
7. Gonzalez NC, Clancy RL, and Wagner PD. Determinants of maximal oxygen uptake in rats acclimated to simulated altitude. J Appl Physiol 75: 1608-1614, 1993.
8. Gonzalez NC, Perry K, Moue Y, Clancy RL, and Piiper J. Pulmonary gas exchange during hypoxic exercise in the rat. Respir Physiol 96: 111-125, 1994.
9. 2 transport in maximal exercise. J Appl Physiol 89: 265-272, 2000.
10. 2 uptake and performance by acute hypoxia in dog muscle in situ. J Appl Physiol 65: 815-821, 1988.
11. Holloszy JO and Coyle EF. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 56: 831-838, 1984.
12. Johnson LR and Laughlin MH. Chronic exercise training does not alter pulmonary vasorelaxation in normal pigs. J Appl Physiol 88: 2008-2014, 2000.
13. Johnson LR, Parker JL, and Laughlin MH. Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs. J Appl Physiol 88: 443-451, 2000.
14. Kacimi R, Richalet JP, Corsin A, Abousahl I, and Crozatier B. Hypoxia-induced downregulation of β-adrenergic receptors in rat heart. J Appl Physiol 73: 1377-1382, 1992.
15. Kashimura O and Sakai A. Effects of physical training on pulmonary arterial pressure during exercise under hypobaric hypoxia in rats. Int J Biometeorol 35: 214-221, 1991.
16. Kashimura O, Sakai A, and Yanagidaira Y. Effects of exercise-training on hypoxia and angiotensin II-induced pulmonary vasoconstrictions. Acta Physiol Scand 155: 291-295, 1995.
17. Levine BD and Stray-Gundersen J. "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance. J Appl Physiol 83: 102-112, 1997.
18. 2 transport and uptake in hypoxic and normoxic exercise. J Appl Physiol 86: 1257-1263, 1999.
19. Miyazaki S and Sakai A. The effect of "living high-training low" on physical performance in rats. Int J Biometeorol 44: 24-30, 2000.
20. Nadaud S, Philippe M, Arnal JF, Michel JB, and Soubrier F. Sustained increase in aortic endothelial cell nitric oxide synthase expression in vivo in a model of chronic high blood flow. Circ Res 79: 857-863, 1996.
21. Naeije R. Pulmonary circulation at high altitude. Respiration 64: 429-434, 1997.
22. Pugh LGCE. Cardiac output in muscular exercise at 5800 m (19000 ft). J Appl Physiol 19: 441-447, 1964.
23. Rabinovitch M, Gamble W, Nadas AS, Miettinen OS, and Reid L. Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Am J Physiol Heart Circ Physiol 236: H818-H827, 1979.
24. Richalet JP, Larmignat P, Rathat C, Keromes A, Baud P, and Lhoste F. Decreased cardiac response to isoproterenol infusion in acute and chronic hypoxia. J Appl Physiol 65: 1957-1961, 1988.
25. O2 max. J Appl Physiol 73: 1067-1076, 1992.
26. O2 max in normal humans. J Appl Physiol 67: 291-299, 1989.
27. Sutton JR. Limitations to maximal oxygen uptake. Sports Med 13: 127-133, 1992.