Enhancement of N-nitrosodiethylamine-initiated hepatocarcinogenesis by phenytoin in male F344/NCr rats at a dose causing maximal induction of CYP2B

International Journal of Toxicology

Volumn 20, Issue 2, 2001, Pages 81-87

  Diwan, B A ^a   Henneman, J R ^a   Nims, R W ^a  

^a SAIC FREDERICK INC   (United States)

Author keywords

Cytochrome(s) P450 Induction; F344 Rats; Liver Tumor Promotion; Phenytoin

Indexed keywords

CYTOCHROME P450 2B; CYTOCHROME P450 ISOENZYME; DIMETHYLNITROSAMINE; PHENYTOIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL CARCINOGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INDUCTION; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; RAT;

ADENOMA, LIVER CELL; ADMINISTRATION, ORAL; ANIMALS; ANTICONVULSANTS; ARYL HYDROCARBON HYDROXYLASES; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CYTOCHROME P-450 ENZYME SYSTEM; DIET; DIETHYLNITROSAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; INJECTIONS, INTRAPERITONEAL; LIVER NEOPLASMS, EXPERIMENTAL; MALE; NEOPLASMS, EXPERIMENTAL; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOBARBITAL; PHENYTOIN; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0035015606     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/10915810151115191     Document Type: Article

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