Cytochrome P-450 ω-hydroxylase: A potential O2 sensor in rat arterioles and skeletal muscle cells

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 280, Issue 4 49-4, 2001, Pages

  Kunert, Mary Pat ^a   Roman, Richard J ^a   Alonso Galicia, Magdalena ^a   Falck, John R ^a   Lombard, Julian H ^a,b  

^a MARQUETTE UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

20 hydroxyeicosatetraenoic acid; Autoregulation; Microcirculation; Vascular smooth muscle

Indexed keywords

17 OCTADECYNOIC ACID; ANTIBODY; CYTOCHROME P450 INHIBITOR; CYTOCHROME P450 OMEGA HYDROXYLASE; GLYCOSIDASE; OXYGEN; OXYGENASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERIOLE; ARTICLE; AUTOREGULATION; CONTROLLED STUDY; CREMASTER MUSCLE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MICROCIRCULATION; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; RAT; SENSOR; SKELETAL MUSCLE; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

EID: 0035015343     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.280.4.h1840     Document Type: Article

References (31)

1. Alonso-Garcia M, Drummond HA, Reddy KK, Falck JR, and Roman RJ. Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. Hypertension 29: 320-325, 1997.
2. Baez S. An open cremaster muscle preparation for the study of blood vessels by in vivo microscopy. Microvasc Res 5: 384-394, 1973.
3. Berne RM, Winn HR, and Rubio R. The local regulation of cerebral blood flow. Prog Cardiovasc Dis 24: 243-259, 1981.
4. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
5. Busse R, Pohl U, Kellner C, and Klemm U. Endothelial cells are involved in the vasodilatory response to hypoxia. Pflügers Arch 397: 78-80, 1983.
6. + channels by hypoxia in smooth muscle cells isolated from the pig coronary artery. J Physiol (Lond) 483: 29-39, 1995.
7. Ebeigbe AB. Influence of hypoxia on contractility and calcium uptake in rabbit aorta. Experientia 38: 935-937, 1982.
8. + channels in mediating hypoxic dilation of middle cerebral arteries. Am J Physiol Heart Circ Physiol 267: H580-H586, 1994.
9. + channels in cat cerebral arterial muscle cell membranes. Pflügers Arch 428: 621-630, 1994.
10. Graser T and Rubanyi GM. Different mechanisms of hypoxic relaxation in canine coronary arteries and rat abdominal aortas. J Cardiovasc Pharmacol 20: S117-S119, 1992.
11. Haddy FJ and Scott JB. Metabolically linked vasoactive chemicals in local regulation of blood flow. Physiol Rev 48: 688-707, 1968.
12. Harder DR, Gebremedhin D, Narayanan J, Jefcoat C, Falck JR, Campbell WB, and Roman RJ. Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. Am J Physiol Heart Circ Physiol 266: H2098-H2107, 1994.
13. Harder DR, Narayanan J, Birks EK, Liard JF, Imig JD, Lombard JH, Lange AR, and Roman RJ. Identification of a putative microvascular oxygen sensor. Circ Res 79: 54-61, 1996.
14. Hill MA, Simpson BE, and Meininger GA. Altered cremaster muscle hemodynamics due to disruption of the deferential feed vessels. Microvasc Res 39: 349-363, 1990.
15. Imig JD, Zou AP, Stec DE, Harder DR, Falck JR, and Roman RJ. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. Am J Physiol Regulatory Integrative Comp Physiol 270: R217-R227, 1996.
16. Jackson WF. Arteriolar oxygen reactivity is inhibited by leukotriene antagonists. Am J Physiol Heart Circ Physiol 257: H1565-H1572, 1989.
17. 2 responses of hamster cheek pouch arterioles. Am J Physiol Heart Circ Physiol 255: H711-H716, 1988.
18. Jackson WF. Regional differences in mechanism of action of oxygen on hamster arterioles. Am J Physiol Heart Circ Physiol 265: H599-H603, 1993.
19. 2 in hamster muscle, but not cheek pouch epithelium, microcirculation. Am J Physiol Heart Circ Physiol 276: H503-H508, 1999.
20. Ma YH, Gebremedhin D, Schwartzman ML, Falck JR, Clark JE, Masters BS, Harder DR, and Roman RJ. 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. Circ Res 72: 126-136, 1993.
21. Madden JA, Vadula MS, and Kurup VP. Effects of hypoxia and other vasoactive agents on pulmonary and cerebral artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 263: L384-L393, 1992.
22. Marriott JF and Marshall JM. Differential effects of hypoxia upon contractions evoked by potassium and noradrenaline in rabbit arteries in vitro. J Physiol (Lond) 422: 1-13, 1990.
23. Messina EJ, Sun D, Koller A, Wolin MS, and Kaley G. Increases in oxygen tension evoke arteriolar constriction by inhibiting endothelial prostaglandin synthesis. Microvasc Res 48: 151-160, 1994.
24. Okada T, Hypoxia-induced change in prostanoids production and coronary flow in isolated rat heart. J Mol Cell Cardiol 23: 939-948, 1991.
25. Osamu I, Alonso-Galicia M, Hopp K, and Roman RJ. Localization of cytochrome P-450 4A isoforms along the rat nephron. Am J Physiol Renal Physiol 274: P395-F404, 1998.
26. Pearce WJ, Ashwal S, Long DM, and Cuevas J. Hypoxia inhibits calcium influx in rabbit basilar and carotid arteries. Am J Physiol Heart Circ Physiol 262: H106-H113, 1992.
27. Poster SL, Falck JR, and Campbell WB. Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta. Am J Physiol Heart Circ Physiol 261: H843-H852, 1991.
28. Pohl U. Endothelial cells as part of a vascular oxygen-sensing system. Hypoxia-induced release of autacoids. Experientia 46: 1175-1179, 1990.
29. Sun CW, Falck JR, Harder DR, and Roman RJ. Role of tyrosine-kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles. Hypertension 33: 414-418, 1999.
30. Wang MH, Brand-Schieber E, Zand BA, Nguyen X, Falck JR, Balu N, and Schwartzman L. Cytochrome P-450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors. J Pharmacol Exp Ther 284: 966-973, 1998.
31. Zou A-P, Imig JD, Kaldunski M, Ortiz de Montellano PR, Zhihua S, and Roman RJ. Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow. Am J Physiol Renal Fluid Electrolyte Physiol 266: F275-F282, 1994.