An intron 4 gene polymorphism in endothelial cell nitric oxide synthase might modulate lipid metabolism in nondiabetic patients on hemodialysis

Nephron

Volumn 88, Issue 1, 2001, Pages 39-43

  Asanuma, Katsuhiko ^a,c   Yokoyama, Keitaro ^a,b   Tsukada, Toshihiko ^a   Takemoto, Fumi ^a   Hara, Shigeko ^a   Yamada, Akira ^a   Tomino, Yasuhiko ^c  

^a TORANOMON HOSPITAL   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Endothelial constitutive NOS; Hemodialysis; High density lipoprotein; Polymorphism

Indexed keywords

CHOLESTEROL; DNA FRAGMENT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITRIC OXIDE SYNTHASE; TRIACYLGLYCEROL;

ADULT; ALLELISM; ARTICLE; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; ELECTROPHORESIS; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HEMODIALYSIS; HUMAN; HUMAN CELL; INTRON; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; MORTALITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS;

ALLELES; CHOLESTEROL; DIABETIC NEPHROPATHIES; FEMALE; HUMANS; INTRONS; KIDNEY FAILURE, CHRONIC; LIPOPROTEINS, HDL; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, GENETIC; RENAL DIALYSIS; TRIGLYCERIDES;

EID: 0035015082     PISSN: 00282766     EISSN: None     Source Type: Journal    
DOI: 10.1159/000045957     Document Type: Article

References (17)

1. Lindner A, Charra B, Sherrard DJ, Scribner BH: Accelerated atherosclerosis in prolonged maintenance hemodialysis. N Engl J Med 1974;290:697-701.
2. Raine AE, Margreiter R, Brunner FP, Ehrich JH, Geerlings W, Landais P, Loirat C, Mallick NP, Selwood NH, Tufveson G, Valderrabano F: Report on management of renal failure in Europe. XXII, 1991. Nephrol Dial Transplant 1992;7(suppl 2):7-35.
3. Chan MK, Varghese Z, Moorhead JF: Lipid abnormalities in uremia, dialysis, and transplantation. Kidney Int 1981;19:625-637.
4. Appel G: Lipid abnormalities in renal disease. Kidney Int 1991;39:169-183.
5. Shoji T, Nishizawa Y, Kawagishi T, Tanaka M, Kawasaki K, Tabata T, Inoue T, Morii H: Atherogenic lipoprotein changes in the absence of hyperlipidemia in patients with chronic renal failure treated by hemodialysis. Atherosclerosis 1997;131:229-236.
6. Goldberg AP, Harter HR, Patsch W, Schechtman KB, Province M, Weerts C, Kuisk I, McCrate MM, Schonfeld G: Racial differences in plasma high-density lipoproteins in patients receiving hemodialysis. N Engl J Med 1983; 308:1245-1252.
7. Wang XL, Sim AS, Badenhof RF, McCredie RM, Wilcken DE: A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat Med 1996;2:41-45.
8. Ichihara S, Yamada Y, Fujimura T, Nakashima N, Yokota M: Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial infarction in the Japanese population. Am J Cardiol 1998; 81:83-86.
9. Yokoyama K, Tsukada T, Matsuoka H, Hara S, Yamada A, Kawaguchi Y: High accummulation of endothelial nitric oxide synthase: A gene polymorphism in patients with end-stage renal disease. Nephron 1998;79:360-361.
10. Uwabo J, Soma M, Nakayama T, Kanmatsuse K: Association of a variable number of tandem repeats in the endothelial constitutive nitric oxide synthase gene with essential hypertension in Japanese. Am J Hypertens 1998;11: 125-128.
11. Marsden PP, Heng HQ, Scherer SW, Stewart RJ, Hall AV, Shi XM, Tsui LC, Schappert KT: Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J Biol Chem 1993;268:17478-17488.
12. Miyahara K, Kawamoto T, Sase K, Yui Y, Toda K, Yang LX, Hattori R, Aoyama T, Yamamoto Y, Doi Y, Ogoshi S, Hashimoto K, Kawai C, Sasayama S, Shizuta Y: Cloning and structural characterization of the human endothelial nitric-oxide-synthase gene. Enr J Biochem 1994;223:719-726.
13. Tsukada T, Yokoyama K, Arai F, Hara S, Yamada A, Kawaguchi Y, Hosoya T, Igari J: Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Biochem Biophys Res Commun 1998;245:190-193.
14. Mehta JL, Chen LY: Reversal by high-density lipoprotein of the effect of oxidized low-density lipoprotein on nitric oxide synthase protein expression in human platelets. J Lab Clin Med 1996;127:287-295.
15. Friedwald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
16. Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Castelli WP, Knoke JD, Jacobs DR Jr, Bangdiwala S, Tyroler HA: High-density lipoprotein cholesterol and cardiovascular disease. Circulation 1989;79:8-15.
17. Cooke JP, Tsao PS: Is NO an endogenous anti-atherogenic molecule? Arterioscler Thromb 1994;14:653-655.