Estimating the frequency distribution of crossovers during meiosis from recombination data

Biometrics

Volumn 57, Issue 2, 2001, Pages 427-434

  Yu, Kai ^a   Feingold, Eleanor ^a  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Bootstrap procedure; Calibrated bootstrap; Crossover; EM algorithm; Genetic recombination; Maximum likelihood estimation; Meiosis

Indexed keywords

CHROMOSOMES; FREQUENCY ESTIMATION; STATISTICAL METHODS;

BOOTSTRAP PROCEDURE; CALIBRATED BOOTSTRAP; CONFIDENCE INTERVAL; CROSS-OVER PROBABILITY; CROSSOVER; EM ALGORITHMS; FREQUENCY DISTRIBUTIONS; GENETIC RECOMBINATIONS; MAXIMUM-LIKELIHOOD ESTIMATION; MEIOSIS;

MAXIMUM LIKELIHOOD ESTIMATION;

ALGORITHM; ARTICLE; CROSSING OVER; GENE CONSTRUCT; GENETIC RECOMBINATION; HYPOTHESIS; MEASUREMENT; MEIOSIS; NONHUMAN; PROBABILITY; SIMULATION;

EID: 0035013275     PISSN: 0006341X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0006-341X.2001.00427.x     Document Type: Article

References (14)

1. Bugge, M., Collins, A., Peterson, M. B., et al. (1998). Nondisjunction of chromosome 18. Human Molecular Genetics 7, 661-669.
2. Dausset, J., Cann, H., Cohen, D., Lathrop, M., Lalouel, J.-M., and White, R. (1990). Centre of Etude du Polymorphisme Human (CEPH): Collaborative genetic mapping of the human genome. Genomics 6, 575-577.
3. Dempster, A. P., Laird, N. M., and Rubin, D. R. (1977). Maximum likelihood from incomplete data via the EM algorithm. Journal of the Royal Statistical Society, Series B 39, 1-22.
4. Efron, B. (1982). The Jackknife, the Bootstrap and Other Resampling Plans. Philadelphia: Society for Industrial and Applied Mathematics.
5. Efron, B. and Tibshirani, R. J. (1993). An Introduction to the Bootstrap. New York: Chapman and Hall.
6. Geyer, C. J. (1994). On the asymptotics of constrained M-estimation. The Annals of Statistics 22, 1993-2010.
7. Lamb, N. E., Feingold, E., Savage, A., et al. (1997a). Characterization of susceptible chiasma configurations that increase the risk for maternal nondisjunction of chromosome 21. Human Molecular Genetics 6, 1391-1399.
8. Lamb, N. E., Feingold, E., and Sherman, S. L. (1997b). Estimating meiotic exchange patterns from recombination data: An application to humans. Genetics 146, 1011-1017.
9. Morton, N. E., Keats, B. J., Jacobs, P. A., Hassold, T., Pettay, D., Harvey, J., and Andrews, V. (1990). A centromere map of the X chromosome from trisomies of maternal origin. Annals of Human Genetics 54, 39-47.
10. Ott, J. (1995). Estimating crossover frequencies and testing for numerical interference with highly polymorphic markers. In Genetic Mapping and DNA Sequencing, Volume 81, The IMA Volumes in Mathematics and Its Applications, T. Speed and M. S. Waterman (eds), 49-63. New York: Springer-Verlag.
11. Press, W. H., Flannery, B. P., Teukolsky, S. A., and Vetterling, W. T. (1986). Numerical Recipes. Cambridge: Cambridge University Press.
12. Weinstein, A. (1936). The theory of multiple strand crossover. Genetics 21, 155-199.
13. Yu, K. (2000). Statistical methods for analyzing tetrad crossover probabilities. Ph.D. dissertation, University of Pittsburgh.
14. Zwick, M. E., Cutler, D. J., and Langley, C. H. (1999). Classic Weinstein: Tetrad analysis, genetic variation and achiasmate segregation in Drosophila and humans. Genetics 152, 1615-1629.