Simultaneous determination of SU5416 and its phase I and phase II metabolites in rat and dog plasma by LC/MS/MS

Journal of Pharmaceutical and Biomedical Analysis

Volumn 25, Issue 5-6, 2001, Pages 821-832

  Zhao, Yeping ^a   Yang, Cheng Y ^a   Haznedar, Joshua ^a   Antonian, Lida ^a  

^a SUGEN INC   (United States)

Author keywords

Drug analysis; LC MS MS; Liquid chromatography; Mass spectrometry; SU5416

Indexed keywords

3 [(4,5 DIMETHYL 1H PYRROL 2 YL)METHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; 5' ACYL GLUCURONIDE; 5' HYDROXYGLUCURONIDE; ANGIOGENESIS INHIBITOR; DRUG METABOLITE; SU 6595; SU 6689; SU 9815; SU 9838; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANGIOGENESIS; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; CYTOSTASIS; DOG; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCIBILITY; TOXICOKINETICS; VALIDATION PROCESS;

ANGIOGENESIS INHIBITORS; ANIMALS; CHROMATOGRAPHY, LIQUID; DOGS; INDOLES; MASS SPECTROMETRY; PYRROLES; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 0035012816     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(01)00341-7     Document Type: Article

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