Nimesulide in the treatment of primary dysmenorrhea: A double-blind study versus diclofenac

Drugs of Today

Volumn 37, Issue SUPPL. B, 2001, Pages 39-45

  Facchinetti, F ^a,c   Piccinini, F ^a   Sgarbi, L ^a   Renzetti, D ^b   Volpe, A ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b Studi Clinici e Biometrici   (Italy)

^c Clinica Ostetrica e Ginecologica   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DICLOFENAC; DICLOREUMA; NIMESULIDE; PLACEBO;

ABDOMINAL PAIN; ADOLESCENT; ADULT; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DYSMENORRHEA; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; PAIN ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; STATISTICAL ANALYSIS; SYMPTOMATOLOGY;

EID: 0035012226     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (14)

1. Lennane, K.J., Lennane, R.J. Alleged psychogenic disorders in women - a possible manifestation of sexual prejudice. N Engl J Med 1973, 288: 288.
2. Dawood, M.Y. Nonsteroidal antiinflammatory drugs and reproduction. Am J Obstet Gynecol 1993, 169: 1255-65.
3. Lundstrom, V., Green, K., Svanborg, K. Endogenous prostaglandins in dysmenorrhea and effect of prostaglandin synthetase inhibitors (PGSI) on uterine contractility. Acta Obstet Gynecol Scand 1979, 87 (Suppl.): 51-6.
4. Chan, W.Y., Dawood, M.Y., Fuchs, F. Relief of dysmenorrhea with the prostaglandin synthetase inhibitor ibuprofen: Effect on prostaglandin levels in menstrual fluid. Am J Obstet Gynecol 1979, 135: 102-8.
5. Marchini, M., Tozzi, L., Bakshi, R., Pisati, R., Fedele, L. Comparative efficacy of diclofenac dispersible 50 mg and ibuprofen 400 mg in patients with primary dysmenorrhea. Int J Clin Pharmacol Therap 1995, 33: 491-97.
6. Mathies, H. The mechanism of action of antirheumatic agents. Triangle 1979, 18 (2-3): 63-73.
7. Garagiola, U., Grossi, E. Sodium diclofenac in the treatment of dysmenorrhea: Clinical studies review. Gaz Med It Arch Sc Med 1986, 145: 311-16.
8. Palumbo, G. Nimesulide nel trattamento della dismenorrea primaria. Valutazione comparativa dell'effetto "dose-risposta" dopo monosomministrazione orale di 50, 100 o 200 mg. Studio multicentrico, randomizzato, in doppio cieco, a gruppi paralleli, controllato verso placebo. Internal report.
9. Riihiluoma, P., Wuolijoki, E., Fulkkinen, M.G. Treatment of primary dysmenorrhoea with diclofenac sodium. Europ J Obstet Gynec Reprod Biol 1981, 12, 189-93.
10. Moggian, G., Pellegri, E., Tamburini, E., Pini, P., Tumidei, U. A new treatment for primary dysmenorrhoea. Clinica Therapeutica 1986, 117: 481-92.
11. Rondel, R.K., Eberhardt, R., Koch, J., Schuerman, W. Treatment of primary essential dysmenorrhoea with nimesulide in a double-blind cross-over study. Curr Ther Res 1984, 35: 123-9.
12. Pulkkinen, M.O. Alterations in intrauterine pressure, menstrual fluid prostaglandin F levels, and pain in dysmenorrheic women treated with nimesulide. J Clin Pharmacol 1987, 27: 65-9.
13. Lopez Rosales, C., Cisneros Lugo, J.H., Romo Enciso, L.J., Garcia Sandoval, M.G. Nimesulide in the treatment of primary dysmenorrhea. Comparative clinical evaluation with mefenamic acid and fentiazac. Ginecol Obstet Mex 1989, 57: 196-201.
14. Rabasseda, X. Nimesulide: A selective cyclooxygenase 2 inhibitor antiinflammatory drug. Drugs Today 1996, 32: 365-84.