The effect of rigidity, shape, unsaturation, and length on the anesthetic potency of hydrocarbons

Anesthesia and Analgesia

Volumn 92, Issue 6, 2001, Pages 1477-1482

  Eger II, Edmond I ^a,b   Laster, Michael J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SAN FRANCISCO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKADIENE; ALKANE; CARBON; HEXANE; HYDROCARBON;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL BOND; DRUG CONFORMATION; DRUG POTENCY; DRUG STRUCTURE; FLUORINATION; MALE; MINIMUM LUNG ALVEOLUS CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0035011302     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-200106000-00025     Document Type: Article

References (12)

1. Molecular properties of the "ideal" inhaled anesthetic: Studies of fluorinated methanes, ethanes, propanes and butanes
2. Hypothesis: Volatile anesthetics produce immobility by acting on two sites approximately five carbons apart
3. MAC of fluorinated alkanols in rats: Relevance to theories of narcosis
4. A cut-off in potency exists in the perfluoroalkanes
5. Structures of molecules and crystals of fluorocarbons
6. Conformational characteristics of poly(tetrafluoroethylene) chains based upon ab initio electronic structure calculations on model molecules
7. 16 segment monitored by fluorescence
8. What solvent best represents the site of action of inhaled anesthetics in humans, rats and dogs?
9. Is there a cutoff in potency for the normal alkanes?
10. Effect of n-alkane kinetics in rats on potency estimations and the Meyer-Overton hypothesis
11. Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis