-
7
-
-
0001203577
-
Preclinical development of antisense therapeutics
-
Novel Therapeutics from Modern Biotechnology: From Laboratory to Human Testing. Oxender DL. Post LE (Eds.), Springer-Verlag, Heidelberg, Germany.
-
(1998)
, pp. 131-163
-
-
Levin, A.A.1
Henry, S.P.2
Bennett, C.F.3
Cole, D.L.4
Hardee, G.E.5
Srivatsa, G.S.6
-
8
-
-
0004951883
-
Pharmacological activity of antisense oligonucleotides in animal models of disease
-
Antisense Research and Applications. Crooke S (Ed.), Springer-Verlag, Berlin, Germany.
-
(1998)
, pp. 427-443
-
-
Monia, B.P.1
Dean, N.M.2
-
12
-
-
0027376439
-
Antisense oligonucleotides as therapeutic agents - Is the bullet really magical?
-
(1993)
Science
, vol.261
, Issue.5124
, pp. 1004-1012
-
-
Stein, C.A.1
Chengg, Y.-C.2
-
15
-
-
0000172356
-
Toxicity of oligodeoxynucleotide therapeutic agents
-
Antisense Research and Application. Crooke ST (Ed.), Springer, Heidelberg, Germany.
-
(1998)
, pp. 169-215
-
-
Levin, A.A.1
Monteith, D.K.2
Leeds, J.M.3
-
17
-
-
0002574175
-
Pharmacokinetic properties of phosphorothioate oligonucleotides in humans
-
Antisense Research and Applications. Crooke ST (Ed.), Springer, Heidelberg, Germany.
-
(1998)
, pp. 217-231
-
-
Leeds, J.M.1
Geary, R.S.2
-
18
-
-
0000433389
-
Pharmacokinetic properties of phosphorothioates in animals - Absorption, distribution, metabolism and elimination
-
Antisense Research and Applications. Crooke ST (Ed.), Springer-Verlag, Berlin, Germany.
-
(1998)
, pp. 141-168
-
-
Nicklin, P.1
Craig, S.2
Phillips, J.3
-
22
-
-
0001203809
-
In vitro cellular uptake, distribution and metabolism of oligonucleotides
-
Antisense Research and Applications. Crooke ST (Ed.), Springer-Verlag, Berlin, Germany.
-
(1998)
, pp. 103-140
-
-
Crooke, R.M.1
-
24
-
-
0004932910
-
Sequence independent plasma and tissue pharmacokinetics for 3 antisense phosphorothioate oligonucleotides: Mouse to man
-
American Association of Pharmaceutical Scientists. Seattle, Washington, USA.
-
(1996)
-
-
Geary, R.S.1
Leeds, J.M.2
Shanahan, W.3
-
27
-
-
0000217983
-
Immune stimulation by oligonucleotides
-
Antisense Research and Applications. Crooke ST (Ed.), Springer-Verlag, Berlin, Germany.
-
(1998)
, pp. 217-262
-
-
Krieg, A.1
-
40
-
-
0001920881
-
Treatment of retinitis induced by cytomegalovirus using intravitreal formivirsen (ISIS 2922)
-
Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors. Wickstrom E (Ed.), Marcel Dekker, Inc., New York, USA.
-
(1998)
, pp. 353-361
-
-
Crooke, S.T.1
-
45
-
-
0030874388
-
Pharmacokinetics of a potential human cytomegalovirus therapeutic, a phosphorothioate oligonucleotide, after intravitreal injections in the rabbit
-
(1997)
Drug Metab. Dispos.
, vol.25
, Issue.8
, pp. 921-926
-
-
Leeds, J.M.1
Henry, S.P.2
Truong, L.3
Zutsi, A.4
Levin, A.A.5
Kornbrust, D.J.6
-
49
-
-
0029839291
-
Targeted delivery of an antisense oligonucleotide in the retina: Uptake, distribution, stability and effect
-
(1996)
Antisense Nucleic Acid Drug Dev.
, vol.6
, Issue.3
, pp. 207-213
-
-
Rakoczy, P.E.1
Lai, M.C.2
Watson, M.3
Seydel, U.4
Constable, I.5
-
51
-
-
0004978404
-
Clinical development of phosphorothioate (P=S) antisense oligodeoxynucleotide inhibitors of PKC-a mRNA (Isis 3521, CGP 64128A) and C-raf kinase (Isis 5132, CGP 69846A)
-
X111th International Congress of Pharmacology. Munich, Germany
-
(1998)
-
-
Dorr, A.F.1
-
52
-
-
0003746427
-
Safety and tolerance of phosphorothioates in humans
-
Antisense Research and Applications. Crooke ST (Ed.), Springer-Verlag, Berlin, Heidelberg, Germany
-
(1998)
, pp. 231-241
-
-
Schechter, P.J.1
Martin, R.R.2
-
56
-
-
0030875072
-
Vascular endothelial growth factor and ocular neovascularization
-
(1997)
Am. J. Pathol.
, vol.151
, Issue.1
, pp. 13-23
-
-
Miller, J.W.1
-
58
-
-
0030758411
-
Vascular endothelial growth factor and the eye: Biochemical mechanisms of action and implications for novel therapies
-
(1997)
Ophthalmic Res.
, vol.29
, pp. 354-362
-
-
Aiello, L.P.1
-
65
-
-
0031954519
-
Death to a blood vessel, death to a tumor
-
(1998)
Nat. Med.
, vol.4
, Issue.4
, pp. 408-414
-
-
Cheresh, D.A.1
-
66
-
-
0032483514
-
Protein kinase G mediates vascular endothelial growth factor-induced raf-1 activation and proliferation in human endothelial cells
-
(1998)
J. Biol. Chem.
, vol.273
, Issue.36
, pp. 23504-23508
-
-
Hood, J.1
Granger, H.J.2
-
68
-
-
0004978405
-
Theory and Practice
-
In Diabetes Mellitus. Rifkin H, Porte D (Ed.), Elsevier Science, New York, USA
-
(1990)
, pp. 220-233
-
-
Osterby, R.1
-
89
-
-
0030641530
-
Humanized antibodies against the alpha-chain of the IL-2 receptor and against the beta-chain shared by the IL-2 and IL-15 receptors in a monkey uveitis model of autoimmune diseases
-
(1997)
J. Immunol.
, vol.158
, Issue.1
, pp. 452-458
-
-
Guex Crosier, Y.1
Raber, J.2
Chan, C.3
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