Induction of apoptosis by 7,8-dihydroneopterin: Involvement of radical formation

Immunobiology

Volumn 203, Issue 4, 2001, Pages 629-641

  Wirlettner, Barbara ^a   Czaputa, Rainer ^b   Oetti, Kari ^b   Böck, Günther ^a   Widner, Bernhard ^a   Reibnegger, Gilbert ^a,b   Baier, Gottfried ^a   Fuchs, Dietmar ^a   Baier Bitterlich, Gabriele ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; 7,8 DIHYDRONEOPTERIN; ANTIOXIDANT; FAS LIGAND; HYDROXYL RADICAL; METAL CHELATE; NEOPTERIN; RADICAL; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

APOPTOSIS; AQUEOUS SOLUTION; ARTICLE; ASSAY; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; GENE ACTIVATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LEUKEMIA CELL LINE; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; SPIN TRAPPING; T LYMPHOCYTE; WESTERN BLOTTING;

EID: 0035008850     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0171-2985(01)80012-7     Document Type: Article

References (43)

1. NATHAN, C. F. 1987. Secretory products of macrophages. J. Clin. Invest. 79: 319.
2. BILLIAU, A., and R. DIJKMANS. 1990. Interferon-gamma: mechanisms of action and therapeutic potential. Biochem. Pharmacol. 40: 1433.
3. HUBER, C., J. R. BATCHELOR, D. FUCHS, A. HAUSEN, A. LANG, D. NIEDERWIESER, G. REIBNEGGER, P. SWETLY, J. TROPPMAIR, and H. WACHTER. 1984. Immune response-associated production of neopterin. J. Exp. Med. 160: 310.
4. BITTERLICH, G., G. SZABO, E. R. WERNER, C. LARCHER, D. FUCHS, A. HAUSEN, G. REIBNEGGER, T. F. SCHULZ, J. TROPPMAIR, and H. WACHTER. 1988. Selective induction of mononuclear phagocytes to produce neopterin by interferons. Immunobiology 176: 228.
5. WERNER, E. R., G. WERNER-FELMAYER, D. FUCHS, A. HAUSEN, G. REIBNEGGER, and H. WACHTER. 1989. Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-γ. Biochem. J. 262: 861.
6. WERNER, E. R., G. WERNER-FELMAYER, D. FUCHS, A. HAUSEN, G. REIBNEGGER, J. J. YIM, W. PFLEIDERER, and H. WACHTER. 1990. Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1 and T24 cells. J. Biol. Chem. 265: 3189.
7. FUCHS, D., M. MALKOVSKY, G. REIBNEGGER, E. R. WERNER, G. FORNI, and H. WACHTER. 1989. Endogenous release of interferon-gamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation. Immunol. Lett. 23: 103.
8. FUCHS, D., G. REIBNEGGER, H. WACHTER, H. JAEGER, M. POPESCU, and W. KABOTH. 1987. Neopterin levels correlating with the Walter Reed staging classification in human immunodeficiency virus (HIV) infection. Ann. Intern. Med. 107: 784.
9. WACHTER, H., D. FUCHS, A. HAUSEN, G. REIBNEGGER, and E. R. WERNER. 1989. Neopterin as a marker for activation of cellular immunity: Immunologic basis and clinical applications. Adv. Clin. Chem. 27: 81.
10. WACHTER, H., D. FUCHS, A. HAUSEN, G. REIBNEGGER, G. WEISS, E. R. WERNER, and G. WERNER-FELMAYER. 1992. Neopterin. Walter de Gruyter, Berlin, New York.
11. WEISS, G., D. FUCHS, A. HAUSEN, G. REIBNEGGER, E. R. WERNER, G. WERNER-FELMAYER, E. SEMENITZ, M. P. DIERICH, and H. WACHTER. 1993. Neopterin modulates toxicity mediated by reactive oxygen and chloride species. FEBS Lett. 321: 89.
12. MURR, C., D. FUCHS, W. GÖSSLER, A. HAUSEN, G. REIBNEGGER, E. R. WERNER, G. WERNER-FELMAYER, H. ESTERBAUER, and H. WACHTER. 1994. Enhancement of hydrogen peroxide-induced luminol-dependent chemiluminescence by neopterin depends on the presence of iron chelator complexes. FEBS Lett. 338: 223.
13. REIBNEGGER, G., D. FUCHS, C. MURR, M. P. DIERICH, W. PFLEIDERER, and H. WACHTER. 1995. Effects of pteridines on luminol-dependent chemilumnescence induced by chloramine-T. Free Radic. Biol. Med. 18: 515.
14. OETTL, K., B. WIRLEITNER, G. BAIER-BITTERLICH, T. GRAMMER, D. FUCHS, and G. REIBNEGGER. 1999. Formation of oxygen radicals in solutions of 7,8-dihydroneopterin. Biochem. Biophys. Res. Commun. 264: 262.
15. BAIER-BITTERLICH, G., D. FUCHS, C. MURR, G. REIBNEGGER, G. WERNER-FELMAYER, R. SGONC, G. BÖCK, M. P. DIERICH, and H. WACHTER. 1995. Effect of neopterin and 7,8-dihydroneopterin on tumor necrosis factor-α induced programmed cell death. FEBS Lett. 364: 234.
16. BAIER-BITTERLICH, G., G. BAIER, D. FUCHS, G. BÖCK, A. HAUSEN, G. UTERMANN, M. PAVELKA, and H. WACHTER. 1996. Role of 7,8-dihydroneopterin in T-cell apoptosis and HTLV-1 transcription in vitro. Oncogene 13: 2281.
17. WIRLEITNER, B., G. BAIER-BITTERLICH, G. BÖCK, B. WIDNER, and D. FUCHS. 1998. 7,8-Dihydroneopterin-induced apoptosis in Jurkat T lymphocytes: a comparison with anti-Fas-and hydrogen peroxide-mediated cell death. Biochem. Pharmacol. 56: 1181.
18. SCHRECK, R., P. RIEBER, and P. A. BAEUERLE. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kB transcription factor and HIV-1. EMBO 10: 2247.
19. GREENSPAN, H. C., and O. I. ARUOMA. 1994. Oxidative stress and apoptosis in HIV infection: a role for plant-derived metabolites with synergistic antioxidant activity. Immunol. Today 15: 209.
20. YODOI, J., and T. UCHIYAMA. 1992. Diseases associated with HTLV-I: virus, IL-2 receptor dysregulation and redox regulation. Immunol. Today 13: 405.
21. BUTTKE, T. M. and P. A. SANDSTROM. 1994. Oxidative stress as a mediator of apoptosis. Immunol. Today 15: 7.
22. LAURENT-CRAWFORD, A. G., B. KRUST, S. MULLER, Y. RIVIERE, M. A. REY-CUILEE, J. M. BECHET, L. MONTAGNIER, and A. G. HOVANESSIAN. 1991. The cytopathic effect of HlV is associated with apoptosis. Virology 185: 829.
23. GOLSTEIN, P., D. M. OJCIUS, and J. D. YOUNG. 1991. Cell death mechanisms and the immune systems. Immunol. Rev. 121: 29.
24. GHAFFARI-TABRIZI, N., B. BAUER, A. VILLUNGER, G. BAIER-BITTERLICH, A. ALTMAN, G. UTERMANN, F. UBERALL, and G. BAIER. 1999. Protein kinase C theta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells. Eur. J. Immunol. 29: 132.
25. FADOK, V. A., D. R. VOELKER, P. A. CAMPBELL, J. J. COHEN, G. L. BRATTON, and P. M. HENSON. 1992. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148: 2207.
26. KASIBHATLA, S., T. BRUNNER, L. GENESTIER, H. ECHEVERRI, A. MAHBOUBI, and D. GREEN. 1998. DNA Damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via activation of NF-xB and AP-1. Molecular Cell 1: 543.
27. ZHOU, Q., S. SNIPAS, K. ORTH, M. MUZIO, V. M. DIXIT, and G. S. SALVESEN. 1997. Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J. Biol. Chem. 272: 7797.
28. WACHTER, H., D. FUCHS, A. HAUSEN, C. HUBER, O. KNOSP, G. REIBNEGGER, and T. J. SPIRA. 1983. Elevated urinary neopterin levels In patients with the acquired immunodeficiency syndrome (AIDS). Hoppe Seyler's Z. Physiol. Chem. 364: 1345.
29. KAMIHIRA, S., Y. YAMAHA, Y. HIRAGATA, T. YAMAGUCHI, K. IZUMIKAWA, Y. MATSUO, K. SUGAHARA, K. TSURUTA, S. ATOGAMI, K. TSUKASAKI, T. MAEDA, and M. TOMONAGA. 1997. Serum levels of soluble Fas/APO-1 receptor in human retroviral infection and associated diseases. Intern. Med. 36: 166.
30. OYAIZU, N., T. W. MCCLOSKEY, M. CORONESI, N. CHIRMULE, V. S. KALYANARAMAN, and S. PAHWA. 1993. Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals. Blood 82: 3392.
31. GOUGEON, M. L., and L. MONTAGNIER. 1993. Apoptosis in AIDS. Science 260: 1269.
32. ENARI, M., H. HUG, and S. NAGATA. 1995. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375: 78.
33. LOS, M., M. VAN DE CRAEN, L. C. PENNING, H. SCHENK, M. WESTENDORP, P. A. BAEUERLE, W. DROGE, P. H. KRAMMER, W. FIERS, and K. SCHULZE-OSTHOFE. 1995. Requirement of an ICE/CED-3 protease tor Fas/APO-1-mediated apoptosis. Nature 375: 81.
34. HASEGAWA, J., S. KAMADA, W. KAMIIKE, S. SHIMIZU, T. IMAZU, H. MATSUDA, and Y. TSUJIMOTO. 1996. Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis. Cancer Res. 56: 1713.
35. BAUER, M. K., M. VOGT, M. LOS, J. SIEGEL, S. WESSELBORG, and K. SCHULZE-OSTHOFF. 1998. Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression. J. Biol. Chem. 273: 8048.
36. KLEBANOFF, S. J. 1988. Oxygen metabolites from phagocytes. In Inflammation: Basic principles and clinical correlates. J. I. Gallin, I. M. Goldstein, R. Snyderman, eds. Raven Press, New York 541 pp.
37. GRAF, E., J. R. MAHONEY, R. G. BRYANT, and J. W. EATON. 1984. Iron-catalysed hydroxyl radical formation. Stringent requirement for free iron coordination site. J. Biol. Chem. 259: 3620.
38. 2-induced luminol chemiluminescence: mechanistic aspects. Free Radic. Biol. Med. 21: 449.
39. HAUSEN, A., D. FUCHS, G. REIBNEGGER, E. R. WERNER, G. WERNER-FELMAYER, and H. WACHTER. 1990. Reduction of ferric iron by 7,8-dihydroneopterin. Pteridines 2: 83.
40. BLAIR, J. A., and A. J. PEARSON. 1973. A kinetic study of the autoxidation of tetrahydrobiopterin. Tetrahedron Letters 3: 203.
41. NISHIKIMI, M. 1975. The generation of superoxide anion in the reaction of tetrahydropteridines with molecular oxygen. Arch. Biochem. Biophys. 166: 273.
42. BILLIAU, A., and R. DIJKMANS. 1990. Interferon-gamma: mechanism of action and therapeutic potential. Biochem. Pharmacol. 40: 1433.
43. MURR, C., D. FUCHS, W. GOSSLER, A. HAUSEN, G. REIBNEGGER, E. R. WERNER, G. WERNER-FELMAYER, H. ESTERBAUER, and ,. 1994. Enhancement of hydrogen peroxide-induced luminol-dependent chemiluminescence by neopterin depends on the presence of iron chelator complexes. FEBS Lett. 338: 223.