In-vivo kinetics of the interaction between midazolam and erythromycin in rats, taking account of metabolic intermediate complex formation

Journal of Pharmacy and Pharmacology

Volumn 53, Issue 5, 2001, Pages 643-651

  Takedomi, Sayuri ^a   Matsuo, Hirotami ^a   Yamano, Katsuhiro ^b   Ohtani, Hisakazu ^a   Sawada, Yasufumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; ERYTHROMYCIN; MIDAZOLAM;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; IN VIVO STUDY; LIVER MICROSOME; MALE; NONHUMAN; PORTAL VEIN; QUANTITATIVE ASSAY; RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; CYTOCHROME P-450 ENZYME SYSTEM; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; ERYTHROMYCIN; GABA MODULATORS; KINETICS; LIVER; MALE; MIDAZOLAM; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0035007702     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357011775974     Document Type: Article

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