Rapid induction of CD95 ligand and CD4+ T cell-mediated apoptosis by CD137 (4-1BB) costimulation

European Journal of Immunology

Volumn 31, Issue 5, 2001, Pages 1410-1416

  Ebata, Tomohiko ^a   Mogi, Seiki ^a   Hata, Yasuhiro ^a   Fujimoto, Jun Ichiro ^a   Yagita, Hideo ^b   Okumura, Ko ^b   Azuma, Miyuki ^a,c  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; CD137 (4 1BB); CD95L; Costimulation

Indexed keywords

B7 ANTIGEN; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE INHIBITOR; CD137 ANTIGEN; CD137 LIGAND; CD95 LIGAND; CELL SURFACE PROTEIN; CONCANAMYCIN A; FAS LIGAND; FC RECEPTOR; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD3; PERFORIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; FEMALE; GENE MUTATION; GENETIC TRANSFECTION; HOMEOSTASIS; MASTOCYTOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TARGET CELL;

4-1BB LIGAND; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIGENS, CD; ANTIGENS, CD137; ANTIGENS, CD80; APOPTOSIS; CASPASES; CD4-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; FAS LIGAND PROTEIN; FEMALE; MACROLIDES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0035006725     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200105)31:5<1410::AID-IMMU1410>3.0.CO;2-H     Document Type: Article

References (40)

1. Smith, C. A., Farrah, T. and Goodwin, R. G., The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 1994. 76: 959-962.
2. Goodwin, R. G., Din, W. S., Davis-Smith, T., Anderson, D. M., Gimpel, S. D., Sato, T. A., Maliszewski, C. R., Brannan, C. I., Copeland, N. G., Jenkins, N. A., Farrah, T., Armitage, R. J., Fanslow, W. C. and Smith, C. A., Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with himiligy to tumor necrosis factor. Eur. J. Immunol. 1993. 23: 2631-2641.
3. Alderson, M. R., Smith, C. A., Tough, T. W., Davis-Smith, T., Armitage, R. J., Falk, B., Roux, E., Baker, E., Sutherland, G. R., Din, W. S. and Goodwin, R. G., Molecular and biological characterization of human 4-1BB and its ligand. Eur. J. Immunol. 1994. 24: 2219-2227.
4. Pollok, K. E., Kim, Y.-J., Hurtado, J., Zhou, Z., Kim, K. K. and Kwon, B. S., 4-1BB T cell antigen binds to mature B cells and macrophages, and cotimulates anti-μ-primed splenic B cells. Eur. J. Immunol. 1994. 24: 367-374.
5. - T lymphocytes by 4-1BB ligand. J. Immunol. 1997. 158: 551-559.
6. Hurtado, J. C., Kim, S. H., Pollok, K. E., Lee, Z. H. and Kwon, B. S., Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28. J. Immunol. 1995. 155: 3360-3367.
7. Saoulli, K., Lee, S. Y., Cannons, J. L., Yen, W. C., Santana, A., Goldstein, M. D., Bangia, N., DeBenedette, M. A., Mak, T. W., Choi, Y. and Watts, T. H., CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand. J. Exp. Med. 1998. 187: 1849-1862.
8. Melero, I., Shuford, W. W., Newby, S. A., Aruffo, A., Ledbetter, J. A., Hellström, K. E., Mittler, R. S. and Chen, L., Monoclonal antibodies against the 4-1BB T cell activation molecule eradicate established tumors. Nat. Med. 1997. 3: 682-685.
9. DeBenedette, M. A., Wen, T., Bachmann, M. F., Ohashi, P. S., Barber, B. H., Stocking, K. L., Peschon, J. J. and Watts, T. H., Analysis of 4-1BB ligand (4-1 BBL)-deficient mice and of mice lacking both 4-1BB: and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. J. Immunol. 1999. 163: 4833-4841.
10. Tan, J. T., Whitmire, J. K., Murali-Krishna, K., Ahmed, R., Altman, J. D., Mittler, R. S., Sette, A., Pearson, T. C. and Larsen, C. P., 4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination. J. Immunol. 2000. 164: 2320-2325.
11. Leeuwenberg, J. F. M., Spits, H., Tax, W. J. M. and Capel, J. A., Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies. J. Immunol. 1985. 134: 3770-3775.
12. Phillips, J. H. and Lanier, L. L., Lectin-dependent and anti-CD3 induced cytotoxicity are preferentially mediated by peripheral blood cytotoxic T lymphocytes expressing Leu-7 antigen. J. Immunol. 1986. 136: 1579-1585.
13. Azuma, M., Cayabyab, M., Buck, D., Phillips, J. H. and Lanier, L. L., CD28 interaction with B7 co-stimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes. J. Exp. Med. 1992. 175: 353-360.
14. Azuma, M., Cayabyab, M., Phillips, J. H. and Lanier, L. L., Requirements for CD28-dependent T cell-mediated cytotoxicity. J. Immunol. 1993. 150: 2091-2101.
15. Matzinger, P., The JAM test. A simple assay for DNA fragmentation and cell death. J. Immunol. Methods 1991. 145: 185-192.
16. Duke, R. C., Chervenak, R. and Cohen, J. J., Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis. Proc. Natl. Acad. Sci. USA 1983. 80: 6361-6365.
17. Henkart, P. A., Lymphocyte-mediated cytotoxicity: two pathways and multiple effector molecules. Immunity 1994. 1: 343-346.
18. Schwarz, H., Blanco, F. J., von Kempis, J., Valbracht, J. and Lotz, M., ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival. Blood 1996. 87: 2839-2845.
19. Michel, J., Pauly, S., Langstein, J., Krammer, P. H. and Schwarz, H., CD137-induced apoptosis is independent of CD95. Immunology 1999. 98: 42-46.
20. Lynch, D. H., Ramsdell, F. and Alderson, M. R., Fas and FasL in the homeostatic regulation of immune responses. Immunol. Today 1995. 16: 569-574.
21. Norian, L. A., Latinis, K. M., Eliason, S. L., Lyson, K., Yang, C., Ratliff, T. and Koretzky, G. A., The regulation of CD95 (Fas) ligand expression in primary T cells: Induction of promoter activation in CD95LP-Luc transgenic mice. J. Immunol. 2000. 164: 4471-4480.
22. Matsui, K., Omura, S., Cui, H., Schauer, S. L., Sonenshein, G. E. and Ju, S. T., Proteasome regulation of Fas ligand cytotoxicity. Eur, J. Immunol. 1997. 27: 2269-2278.
23. Matsui, K., Fine, A., Zhu, B., Marshak-Rothstein, A. and Ju, S. T., Identification of two NF-κB sites in mouse CD95 ligand (Fas ligand) promoter: functional analysis in T cell hybridoma. J. Immunol 1998. 161: 3469-3473.
24. Hsu, S. C., Gavrilin, M. A., Lee, H. H., Wu, C. C., Man, S. H. and Lai, M. Z., NF-κB-dependent Fas ligand expression. Eur. J. Immunol, 1999. 29: 2948-2956.
25. Matsui, K., Xiao, S., Fine, A. and Ju, S. T., Role of activator protein-1 in TCP-mediated regulation of the murine fasl promoter. J. Immunol. 2000. 164: 3002-3008.
26. Woodrow, M., Clipstone, N. A. and Cantrell, D., p21 ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J. Exp. Med. 1993. 178: 1517-1522.
27. Rincon, M. and Flavell, R. A., AP-1 lranscriptional activity requires both T cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J. 1994. 13: 4370-4381.
28. Stancovski, I. and Baltimore, D., NF-kB activation: The IkB kinase revealed? Cell 1997. 91: 299-302.
29. Maggirwar, S. B., Harhaj, E. W. and Sun, S. C., Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-κB/Rel transcription factors. Mol. Cell. biol. 1997. 17: 2605-2614.
30. Arch, R. H., Gedrich, R. W. and Thompson, C. B., Translocation of TRAF proteins regulates apoptotic threshold of cells. Biochem. Biophys. Res. Commun. 2000. 272: 936-945.
31. Jang, I. K., Lee, Z. H., Kim, Y. J., Kim, S. H. and Kwon, B. S., Human 4-1BB (CD137) signals are mediated by TPAF2 and activate nuclear factor-kappa B. Biochem Biophys Res Commun 1998. 242: 613-620.
32. Arch, R. H. and Thompson, C. B., 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappa B. Mol. Cell. Biol. 1998. 18: 558-565.
33. Cannons, J. L., Hoeflich, K. P., Woodgett, J. R. and Watts, T. H., Role of the stress kinase pathway in signaling via the T cell costimulatory receptor 4-1BB. J. Immunol. 1999. 163: 2990-2998.
34. + murine squamous cell carcinoma and the requirements of costimulatory molecules on tumor and host cells. Immunology 2000. 101: 541-547.
35. Nakajima, A., Azuma, M., Kodera, S., Nuriya, S., Terashi, A., Abe, M., Hirose, S., Shirai, T., Yagita, H. and Okumura, K., Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule. Eur. J. Immunol. 1995. 25: 3060-3069.
36. Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., Nohara, C., Yagita, H. and Okumura, K., CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J. Immunol. 1999. 162: 7058-7066.
37. Seino, K., Kayagaki, N., Bashuda, H., Okumura, K. and Yagita, H., Contribution of Fas ligand to cardiac allograft rejection. Int. Immunol. 1996. 8: 1347-1354.
38. Nuriya, S., Yagita, H., Okumura, K. and Azuma, M., The differential role of CD86 and CD80 co-stimulatory molecules in the induction and the effector phases of contact hypersensitivity. Int. Immunol. 1996. 8: 917-926.
39. Lanier, L. L. and Recktenwald, D. J., Multicolor immunofluorescence and flow cytometry. Methods: A Companion to Methods Enzymol. 1991. 2: 192-199.
40. + T cells. J. Immunol. 2000. 164: 664-669.