Effects of STN lesions on simple vs choice reaction time tasks in the rat: Preserved motor readiness, but impaired response selection

European Journal of Neuroscience

Volumn 13, Issue 8, 2001, Pages 1609-1616

  Baunez, Christelle ^a,d   Humby, Trevor ^b   Eagle, Dawn M ^b   Ryan, Lawrence J ^c   Dunnett, Stephen B ^b,e   Robbins, Trevor W ^a  

^a UK   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c OREGON STATE UNIVERSITY   (United States)

^d CNRS   (France)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Basal ganglia; Choice reaction time; Cognition; Motor programming; Motor readiness; Simple reaction time

Indexed keywords

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTINGENT NEGATIVE VARIATION; CONTROLLED STUDY; HISTOPATHOLOGY; MALE; MOTOR PERFORMANCE; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; RAT; REACTION TIME; SUBTHALAMIC NUCLEUS; TASK PERFORMANCE;

ANIMALS; BEHAVIOR, ANIMAL; CHOICE BEHAVIOR; MALE; MOTOR ACTIVITY; RATS; RATS, INBRED STRAINS; REACTION TIME; REINFORCEMENT (PSYCHOLOGY); SUBTHALAMIC NUCLEUS;

EID: 0035003990     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816x.2001.01521.x     Document Type: Article

References (32)

1. Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced parkinsonism in the primate
2. In a rat model of parkinsonism, lesions of the subthalamic nucleus reverse increases of reaction time, but induce a dramatic premature responding deficit
3. Dopamine and complex sensorimotor integration: Further studies in a conditioned motor task in the rat
4. Bilateral lesions of the subthalamic nucleus induce multiple deficits in an attentional task in rats
5. Effects of transient inactivation of the subthalamic nucleus by local muscimol and APV infusions on performance on the five-choice serial reaction time task in rats
6. Reversal of rigidity and improvement in motor performance by subthalamic high frequency stimulation in MPTP-treated monkey
7. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus
8. A computational model of how the basal ganglia produce sequences
9. Simple and choice reaction time performance following unilateral striatal dopamine depletion in the rat. Impaired motor readiness but preserved response preparation
10. Routes to action in reaction time tasks
11. From experimentation to the surgical treatment of Parkinson's disease: Prelude or suite in basal ganglia research?
12. Subthalamic nucleus lesions induce deficits as well as benefits in the hemiparkinsonian rat
13. Distributed modular architectures linking basal ganglia, cerebellum, and cerebral cortex: Their role in planning and controlling action
14. Simple and choice reaction time and the use of advance information for motor preparation in Parkinson's disease
15. Cortical inputs to the subthalamus: Intracellular analysis
16. Effects on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation
17. Effects of time uncertainty on the time course of preparatory processes in cats performing a RT task
18. Relationship of activity in the subthalamic nucleus-globus pallidus network to cortical electro-encephalogram
19. The basal ganglia: Focused selection and inhibition of competing motor programs
20. Expectancy and preparation in simple reaction time
21. Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkey
22. Mazes, maps and memory
23. Reaction time performance following unilateral striatal dopamine depletion and lesions of the subthalamic nucleus in the rat
24. A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus
25. Dopaminergic effects on simple and choice reaction time performance in Parkinson's disease
26. The neurology of visual attention
27. The basal ganglia: A vertebrate solution to the selection problem?
28. The role of the subthalamic nucleus in the response of globus pallidus neurons to stimulation of the prelimbic and agranular frontal cortices in rats
29. Ballism and the subthalamic nucleus (nucleus hypothalamicus; corpus Luysii)
30. Studies of the subthalamus of the rhesus monkey. II. Hyperkinesia and other physiologic effects of subthalamic lesions, with special references to the subthalamic nucleus of Luys
31. Oscillations in the basal ganglia