Can VEGF reverse diabetic neuropathy in human subjects?

Journal of Clinical Investigation

Volumn 107, Issue 10, 2001, Pages 1215-1218

  Veves, Aristidis ^a   King, George L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSE REDUCTASE INHIBITOR; AMINOGUANIDINE; ANTIOXIDANT; DEFEROXAMINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN RECEPTOR ANTAGONIST; GAMMA LINOLENIC ACID; INSULIN; LEVACECARNINE; NERVE GROWTH FACTOR; NIFEDIPINE; PRAZOSIN; PROTEIN KINASE C INHIBITOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASODILATOR AGENT;

ANGIOGENESIS; ANIMAL MODEL; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEUROPATHY; GENE THERAPY; GENE TRANSFER; HUMAN; HYPERGLYCEMIA; MICROVASCULATURE; NERVE FUNCTION; NONHUMAN; NOTE; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; WOUND HEALING;

EID: 0035003333     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI13038     Document Type: Note

References (21)

1. Diabetic neuropathies
2. Pathogenesis of diabetic neuropathy
3. Screening techniques to identify the at risk patients for developing diabetic foot ulcers in a prospective multicentre trial
4. Diabetic neuropathy, a clinical and histological study on the significance of vascular affection
5. Vascular factors in diabetic neuropathy
6. Local human sural nerve blood flow in diabetic and other polyneuropathies
7. Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial
8. Axonal atrophy in sensory nerves of the diabetic BB-Wistar rat, a possible early correlate of human diabetic neuropathy
9. Nerve blood flow in early experimental diabetes in rats: Relation to conduction deficits
10. Nerve ischaemia in diabetic rats: Time-course of development, effect of insulin treatment plus comparison of streptozotocin and BB models
11. Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor
12. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
13. Tissue responses to ischemia: Local and remote responses for preserving perfusion of ischemic muscle
14. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
15. Vascular endothelial growth factor and diabetes: The agonist versus antagonist paradox
16. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms and endothelial cell growth
17. Vascular endothelial growth factor expression in peripheral nerves and dorsal root ganglia in diabetic neuropathy in rats
18. Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy
19. Reversal of experimental diabetic neuropathy by VEGF gene transfer
20. Metabolic and vascular factors in the pathogenesis of diabetic neuropathy
21. A protein kinase C-betaselective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats