Compensatory up-regulation of angiotensin II subtype 1 receptors in αENaC knockout heterozygous mice

Kidney International

Volumn 59, Issue 6, 2001, Pages 2216-2221

  Wang, Qing ^a   Hummler, Edith ^a   Maillard, Marc ^a   Nussberger, Jurg ^a   Rossier, Bernard C ^a   Brunner, Hans R ^a   Burnier, Michel ^a,b  

^a Inst de Pharmacol et de Toxicol   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Blood pressure; Epithelium sodium channel; Mouse model; Renin angiotensin system; Salt wasting

Indexed keywords

ALDOSTERONE; ANGIOTENSIN; ANGIOTENSIN RECEPTOR; RECEPTOR SUBTYPE; SODIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; HETEROZYGOSITY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; PSEUDOHYPOALDOSTERONISM; RECEPTOR BINDING; RECEPTOR DENSITY; RECEPTOR UPREGULATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SALT LOSING NEPHRITIS; SODIUM BALANCE; SODIUM EXCRETION; SODIUM INTAKE;

EID: 0035000205     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.0590062216.x     Document Type: Article

References (20)

1. Rossier BC: The renal epithelial sodium channel: New insights in understanding hypertension. Adv Nephrol 25:275-286, 1996
2. + channel is made of three homologous subunits. Nature 367:463-467, 1994
3. McDonald FJ, Price MP, Snyder PM, Welsh MJ: Cloning and expression of the β- and γ-subunits of the human epithelial sodium channel. Am J Physiol 268:C1157-C1163, 1995
4. + channel. Am J Physiol 266:L728-L734, 1994
5. Hummler E, Barker P, Gatzy J. et al: Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice. Nat Genet 12:325-328, 1996
6. Hummler E, Barker P, Talbot C, et al: A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism. Proc Nat Acad Sci USA 94:11710-11715, 1997
7. Wang Q, Horisberger JD, Maillard M, et al: Salt-and angiotensin II-dependent variations in amiloride-sensitive rectal potential difference in mice. Clin Exp Pharmacol Physiol 27:60-66, 2000
8. Cazaubon C, Gougat J, Bousquet F, et al: Pharmacological characterisation of SR 47436, a new nonpeptide AT1 subtype angiotensin II receptor antagonist. J Pharmacol Exp Ther 265:826-834, 1993
9. Burnier M, Centeno G, Waeber G, et al: Effect of endotoxin on the angiotensin II receptor in cultured vascular smooth muscle cells. Br J Pharmacol 116:2524-2530, 1995
10. Nussberger J, Fasanella D'Amore T, Porchet M, et al: Repeated administration of the converting enzyme inhibitor cilazapril to normal volunteers. J Cardiovasc Pharmacol 9:39-44, 1987
11. Wiesel P, Mazzolai L, Nussberger J, Pedrazzini T: Two-kidney, one clip and one-kidney, one clip hypertension in mice. Hypertension 29:1025-1030, 1997
12. Chang SS, Gründer S, Hanukoglu A. et al: Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalasmic acidosis, psuedohypoaldosteronism type 1. Nat Genet 12:248-253, 1996
13. Waeber B, Nussberger J, Brunner HR: Angiotensin-converting enzyme inhibitors in hypertension, in Hypertension: Pathophysiology, Diagnosis, and Management, edited by Laragh JH, Brenner BM, New York, Raven Press, pp 2209-2232, 1990
14. Mimran A, Jover B, Casellas D: Renal adaptation to sodium deprivation: Effect of captopril in the rat. Am J Med 76:14-21, 1984
15. Ullian ME, Schelling JR, Linas SL: Aldosterone enhances angiotensin II receptor binding and inositol phosphate responses. Hypertension 20:67-73, 1992
16. Wang DH, Qiu J, Hu Z: Differential regulation of angiotensin II receptor subtypes in the adrenal gland: Role of aldostrone. Hypertension 32:65-70, 1998
17. Douglas J: Corticosteroids decrease glomerular angiotensin receptors. Am J Physiol 252(3 Pt 2):F453-F457, 1987
18. Robert V, Hesmes C, Silvestre JS, et al: Angiotensin AT1 receptor subtype as a cardiac target of aldosterone: Role in aldosterone-salt-induced fibrosis. Hypertension 33:981-986, 1999
19. Vander AJ, Geelhoed GW: Inhibition of renin secretion by angiotensin II. Proc Soc Exp Biol Med 120:399-403, 1965
20. Christen Y, Waeber B, Nussberger J, et al: Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers: Inhibition of pressor response to exogenous angiotensin I and II. Circulation 83:1333-1342, 1991