Immunoregulatory activity, biochemistry, and phylogeny of ovine uterine serpin

American Journal of Reproductive Immunology

Volumn 45, Issue 5, 2001, Pages 266-272

  Peltier, Morgan R ^a   Hansen, Peter J ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Immunosuppression; Progesterone; Sheep; Uterine serpin

Indexed keywords

INTERLEUKIN 2; MITOGENIC AGENT; OVINE UTERINE SERPIN; PROGESTERONE; PROTEIN KINASE C; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ALLOGRAFT; ANTIBODY PRODUCTION; ARTIODACTYLA; BIOCHEMISTRY; CATTLE; ENDOMETRIUM; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; GENE; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; MOLECULAR EVOLUTION; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; REPRODUCTIVE HEALTH; REVIEW; SHEEP; SWINE; T LYMPHOCYTE;

EID: 0034997857     PISSN: 87558920     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.8755-8920.2001.450502.x     Document Type: Review

References (61)

1. Hansen PJ, Bazer FW, Segerspon EC: Skin graft survival in the uterine lumen of ewes treated with progesterone. Am J Reprod Immunol Microbiol 1986; 12:48-54.
2. Staples LD, Binns RM, Heap RB: Influence of certain steroids on lymphocyte transformation in sheep and goats studied in vitro. J Endocrinol 1983; 98:55-69.
3. Low BG, Hansen PJ: Actions of steroids and prostaglandins secreted by the placenta and uterus of the cow and ewe on lymphocyte proliferation in vitro. Am J Reprod Immunol Microbiol 1988; 18:71-75.
4. Monterosso VH, Hansen PJ: Regulation of bovine and ovine lymphocyte proliferation by progesterone: modulation by steroid receptor antagonists and physiological status. Acta Endocrinol 1993; 129:532-535.
5. Stephenson DC, Hansen PJ, Newton GR, Bazer FW, Low BG: Inhibition of lymphocyte proliferation by uterine fluid from the pregnant ewe. Biol Reprod 1989; 41:1063-1075.
6. Stephenson DC, Hansen PJ: Induction by progesterone of immunosuppressive activity in uterine secretions of ovariectomized ewes. Endocrinology 1990; 126:3168-3178.
7. Stephenson DC, Hansen PJ, Isaak DD: Inhibition of antigen-and mitogen-induced activation of mouse splenocytes by uterine secretions from pregnant and progesterone-treated ewes. Am J Reprod Immunol 1991; 26:178-185.
8. Skopets B, Hansen PJ: Identification of the predominant proteins in uterine fluids of unilaterally pregnant ewes that inhibit lymphocyte proliferation. Biol Reprod 1993; 49:997-1007.
9. Segerson EC, Moffatt RJ, Bazer FW, Roberts RM: Suppression of phytohemagglutinin-stimulated lymphocyte blastogenesis by ovine uterine milk protein. Biol Reprod 1984; 30:1175-1186.
10. Zhang X, Miller BG: Effects of pregnancy and exogenous progesterone on immunosuppressive activity in the uterus and peripheral plasma of the ewe. Anim Reprod Sci 1989; 18:253-270.
11. Skopets B, Liu WJ, Hansen PJ: Effects of endometrial serpin-like proteins on immune responses in sheep. Am J Reprod Immunol 1995; 33:86-93.
12. Liu WJ, Gottshall SL, Hansen PJ: Increased expression of cell surface markers on endometrial γδ T-cell receptor + intraepithelial lymphocytes induced by the local presence of the sheep conceptus. Am J Reprod Immunol 1997; 37:199-205.
13. Fox A, Lee CS, Brandon MR, Meeusen EN: Effects of pregnancy on lymphocytes within sheep uterine intraplacentome epithelium. Am J Reprod Immunol 1998; 40:295-302.
14. Peltier MR, Liu WJ, Hansen PJ: Regulation of lymphocyte proliferation by uterine serpin: interleukin-2 mRNA production, CD25 expression and responsiveness to interleukin-2. Proc Soc Exp Biol Med 2000; 223:75-81.
15. Liu WJ, Hansen PJ: Effect of the progesterone-induced serpin-like proteins of the sheep endometrium on natural-killer cell activity in sheep and mice. Biol Reprod 1993; 49:1008-1014.
16. Tekin S, Hansen PJ: Inhibitory actions of ovine uterine serpin on cytotoxic lymphocytes from peripheral blood and endometrial epithelium. Am J Reprod Immunol 1999; 41:402-403 (abstract).
17. Hansen PJ, Newton GR: Binding of immunoglobulins to the major progesterone-induced proteins secreted by the sheep uterus. Arch Biochem Biophys 1988; 260:208-217.
18. Moffatt J, Bazer FW, Hansen PJ, Chun PW, Roberts RM: Purification, secretion and immunocytochemical localization of the uterine milk proteins, major progesterone-induced proteins in uterine secretions of the sheep. Biol Reprod 1987; 36:419-430.
19. Newton GR, Hansen PJ, Bazer FW, Leslie MV, Stephenson DC, Low BG: Presence of the major progesterone-induced proteins of the sheep endometrium in fetal fluids. Biol Reprod 1989; 40:417-424.
20. Powell JR, Barratt MEJ, Porter P: The acquisition of immunity by the neonate. In The Acquisition of Immunity by the Neonate, DB Crighton (ed.). London, Butterworths, 1984, pp 265-290.
21. Hansen PJ, Foti SA: Proteins similar to the major proteins in uterine secretions of pregnant ewes are also found in colostrum. J Anim Sci 1986; 63(Suppl 1):53-54.
22. Mathialagan N, Hansen TR: Pepsin-inhibitory activity of the uterine serpins. Proc Natl Acad Sci USA 1996; 93:13653-13658.
23. Liu WJ, Peltier MR, Hansen PJ: Binding of ovine uterine serpin to lymphocytes. Am J Reprod Immunol 1999; 41:428-432.
24. Peltier MR, Raley LC, Liberles DA, Benner SA, Hansen PJ: Evolutionary history of the uterine serpins. J Exp Zool (Mov Dev Evol) 2000; 288:165-174.
25. Mancheno JM, Gasset M, Onaderra M, Gavilnes JG, D'Alessio G: Bovine seminal ribonuclease destabilizes negatively charged membranes. Biochem Biophys Res Commun 1994; 199:119-124.
26. Mastronicola MR, Piccoli R, D'Alessio G: Key extracellular and intracellular steps in the antitumor action of seminal ribonuclease. Eur J Biochem 1995; 230:242-249.
27. Szamel M, Appel A, Schwinzer R, Resch K: Different protein kinase C isoenzymes regulate IL-2 receptor expression or IL-2 synthesis in human lymphocytes stimulated via the TCR. J Immunol 1998; 160:2207-2214.
28. Gomez J, Pitton C, Garcia A, Martinez de Aragon A, Silva A, Rebollo A: The isoform of protein kinase C controls interleukin-2-mediated proliferation in a murine T-cell line: Evidence for an additional role of protein kinase C ε and β. Exp Cell Res 1995; 218:105-113.
29. Hansen PJ, Ing NH, Moffatt RJ, Baumbach GA, Saunders PT, Bazer FW, Roberts RM: Biochemical characterization and biosynthesis of the uterine milk proteins of the pregnant sheep uterus. Biol Reprod 1987; 36:405-418.
30. Ing NH, Roberts RM: The major progesterone-modulated proteins secreted into the sheep uterus are members of the serpin superfamily of serine proteinase inhibitors. J Biol Chem 1989; 264:3372-3379.
31. Castellucci M, Theelen T, Pompili E, Fumagalli L, De Renzis G, Muhlhauser J: Immunohistological localization of serine-proteinase inhibitors in the human placenta. Cell Tissue Res 1994; 278:283-289.
32. Huppertz B, Kertschanska S, Demir AY, Frank H-G, Kaufmann P: Immunohistochemistry of matrix metalloproteinases (MMP), their substrates, and their inhibitors (TIMPS) during trophoblast invasion in the human placenta. Cell Tissue Res 1998; 291:133-148.
33. Stallings-Mann ML, Burke MG, Trout WE, Roberts RM: Purification, characterization and cDNA cloning of a Kunitz-type proteinase inhibitor secreted by the porcine uterus. J Biol Chem 1994; 269:24090-24094.
34. Badinga L, Michel FJ, Fields MJ, Sharp DC, Simmen RCM: Pregnancy-associated endometrial expression of antileukoproteinase gene is correlated with epitheliochorial placentation. Mol Reprod Dev 1994; 38:357-363.
35. Marshal CJ: Evolutionary relationships among the serpins. Phil Trans R Soc Lond B 1993; 342:101-119.
36. Liu WJ, Hansen PJ: Progesterone-induced secretion of dipeptidyl peptidase-IV (cluster differentiation antigen-26) by the uterine endometrium of the ewe and cow that costimulates lymphocyte proliferation. Endocrinology 1995; 136:779-787.
37. 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis. Nature 1985; 317:730-732.
38. Travis J: Serpins: structure and mechanism of action. Biol Chem Hoppe Seyler 1990; 371(Suppl):3-ll.
39. Gettins P, Patston PA, Schapira M: Structure and mechanism of action of serpins. Hematol Oncol Clin North Am 1992; 6:1393-1408.
40. Gettins P, Patston PA, Schapira M: The role of conformational change in serpin structure and function Bioessays 1993; 15:461-467.
41. Travis J: Serpins. From the way it was to the way it is. Adv Exp Med Biol 1997; 425:1-4.
42. Pemberton PA, Stein PE, Pepys MB, Potter JM, Carrell RW: Hormone binding globulins undergo serpin conformational change in inflammation. Nature 1988; 336:257-258.
43. Becerra SP, Sagasti A, Spinella P, Notario V: Pigment eptithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop. J Biol Chem 1995; 270:25992-25999.
44. Pemberton PA, Wong DT, Gibson HL, Kiefer MC, Fitzpatrick PA, Sager R, Barr PJ: The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin. J Biol Chem 1995; 270:15832-15837.
45. 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function. J Mol Biol 1984; 177:531-557.
46. 1-antitrypsin by a peptide sequentially similar to β-strand s4A. Eur J Biochem 1990; 194:51-56.
47. 1-proteinase inhibitor in β-sheet A. Biochemistry 1992; 31:7560-7665.
48. 1-proteinase inhibitor in Escherichia coli: effects of single amino acid substitutions in the active site loop on aggregate formation. J Biotechnol 1994; 32:231-238.
49. Chang WS, Wardell MR, Lomas DA, Carrell RW: Probing serpin reactive-loop conformations by proteolytic cleavage. Biochem J 1996; 314:647-653.
50. 1-antitrypsin for structure and function of serpins. Biochemistry 1989; 28:8951-8966.
51. Potempa J, Korzus E, Travis J: The serpin superfamily of proteinase inhibitors: structure, function, and regulation. J Biol Chem 1994; 269:15957-15960.
52. Stein PE, Tewkesbury DA, Carrell RW: Ovalbumin and angiotensinogen lack serpin S-R conformational change. Biochem J 1989; 262:103-107.
53. Peltier MR, Grant TR, Hansen PJ: Distinct physical and structural properties of the ovine uterine serpin. Biochim Biophys Acta 2000; 1479:37-51.
54. Hansen PJ, Liu WJ: Biochemical/physiological properties of endometrial serpin-like proteins. Adv Contracep Deliv Syst 1996; 10:339-353.
55. Hekman CM, Loskutoff DJ: Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants. J Biol Chem 1985; 260:11581-11587.
56. Wardell MR, Chang WS, Bruce D, Skinner R, Lesk AM, Carrell RW: Preparative induction and characterization of L-antithrombin: a structural homologue of latent plasminogen activator inhibitor-1. Biochemistry 1997; 36:13133-13142.
57. 1-antitrypsin. J Biol Chem 1995; 270:5282-5288.
58. Gils A, Knockaert I, Declerck PJ: Substrate behavior of plasminogen activator inhibitor-1 is not associated with a lack of insertion of the reactive site loop. Biochemistry 1996; 35:7474-7481.
59. Malathy PV, Imakawa K, Simmen RC, Roberts RM: Molecular cloning of the uteroferrin-associated protein, a major progesterone-induced serpin secreted by the porcine uterus, and the expression of its mRNA during pregnancy. Mol Endocrinol 1990; 4:428-440.
60. Laskowski M, Kato I, Kohr WJ, Park SJ, Tashiro M, Whatley HE: Positive Darwinian selection in evolution of protein inhibitors of serine proteinases. Cold Spring Harbor Symp Q Biol 1987; 52:545-553.
61. Baumbach GA, Ketcham CM, Richardson DE, Bazer FW, Roberts RM: Isolation and characterization of a high molecular weight stable pink form of uteroferrin from uterine secretions and allantoic fluid of pigs. J Biol Chem 1986; 261:12869-12878.