Carbapenem-resistant Klebsiella pneumoniae in Singapore producing IMP-1 β-lactamase and lacking an outer membrane protein

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 6, 2001, Pages 1939-1940

  Koh, Tse H ^a   Sng, Li Hwei ^a   Babini, Gioia S ^b   Woodford, Neil ^b   Livermore, David M ^b   Hall, Lucinda M C ^c  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b CENTRAL PUBLIC HEALTH LABORATORY   (United Kingdom)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AZTREONAM; BETA LACTAMASE; CARBAPENEM; CEFEPIME; CEFOTAXIME; CEFOTETAN; CEFOXITIN; CEFTAZIDIME; CEFUROXIME; CHLORAMPHENICOL; CIPROFLOXACIN; CLAVULANIC ACID; CLOXACILLIN; GENTAMICIN; IMIPENEM; MEROPENEM; OUTER MEMBRANE PROTEIN; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; TRIMETHOPRIM;

BACTERIUM ISOLATE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE SEQUENCE; KLEBSIELLA PNEUMONIAE; LETTER; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PENICILLIN RESISTANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SINGAPORE;

BACTERIAL OUTER MEMBRANE PROTEINS; BETA-LACTAMASES; CARBAPENEMS; DRUG RESISTANCE, MICROBIAL; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; SINGAPORE;

EID: 0034996244     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.6.1939-1940.2001     Document Type: Letter

References (9)

1. Chu, Y.-W., M. Afzal-Shah, E. T. S. Houang, M.-F. Palepou, D. J. Lyon, N. Woodford, and D. M. Livermore. 2001. IMP-4, a novel metallo-β-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998. Antimicrob. Agents Chemother. 45:710-714.
2. Hawkey, P. M., J. Xiong, H. Ye, H. Li, and F. H. M'Zali. 2001. Occurrence of a new metallo-beta-lactamase IMP-4 carried on a conjugative plasmid in Citrobacter youngae from the People's Republic of China. FEMS Microbiol. Lett. 194:53-57.
3. Hernandez-Alles, S., S. Alberti, D. Alvarez, A. Domenech-Sanchez, L. Martinez-Martinez, J. Gil, J. M. Tomas, and V. J. Benedi. 1999. Porin expression in clinical isolates of Klebsiella pneumoniae. Microbiology 145:673-679.
4. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 277:680-685.
5. IMP-containing Pseudomonas aeruginosa integron phyletically related to In5, which carries an unusual array of gene cassettes. Antimicrob. Agents Chemother. 43:890-901.
6. Livermore, D. M., and J. D. Williams. 1996. β-Lactams: mode of action and mechanisms of bacterial resistance, p. 502-578. In V. Lorian (ed.). Antibiotics in laboratory medicine, 4th ed. Williams & Wilkins, Baltimore, Md.
7. National Committee for Clinical Laboratory Standards. 1997. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 4th ed. Approved standard M7-A4. National Committee for Clinical Laboratory Standards, Wayne, Pa.
8. Osano, E., Y. Arakawa, R. Wacharotayankun, M. Ohta, T. Horii, H. Ito, F. Yoshimura, and N. Kato. 1994. Molecular characterization of an enterobacterial metallo β-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance. Antimicrob. Agents Chemother. 38:71-78.
9. IMP alleleic variants carried by gene cassettes of different phylogeny. Antimicrob. Agents Chemother. 44:1229-1235.