PKD in intestinal epithelial cells: Rapid activation by phorbol esters, LPA, and angiotensin through PKC

American Journal of Physiology - Cell Physiology

Volumn 280, Issue 4 49-4, 2001, Pages

  Chiu, Terence ^a   Rozengurt, Enrique ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Epithelial restitution; Gi and Gq; IEC 18 cells; Lysophosphatidic acid, protein kinase C downregulation

Indexed keywords

ANGIOTENSIN; LYSOPHOSPHATIDIC ACID; PERTUSSIS TOXIN; PHORBOL DIBUTYRATE; PROTEIN KINASE C; PROTEIN KINASE D; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INTESTINE EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034996179     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2001.280.4.c929     Document Type: Article

References (11)

1. Abraham C, Scaglione-Sewell B, Skarosi SF, Qin W, Bissonnette M, and Brasitus TA. Protein kinase C alpha modulates growth and differentiation in Caco-2 cells. Gastroenterology 114: 503-509, 1998.
2. Alessi DR, Cuenda A, Cohen P, Dudley DT, and Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem. 270: 27489-27494, 1995.
3. An S, Bleu T, Zheng Y, and Goetzl EJ. Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. Mol Pharmacol 54:881-888,1998.
4. Andrâe F, Rigot V, Remacle-Bonnet M, Luis J, Pommier G, and Marvaldi J. Protein kinases C-gamma and -delta are involved in insulin-like growth factor I-induced migration of colonie epithelial cells. Gastroenterology 116: 64-77, 1999.
5. Bagowski CP, Stein-Gerlach M, Choidas A, and Ullrich A. Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor. EMBO J 18: 5567-5576, 1999.
6. Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Aral H, and Inoue K. Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem 274: 27776-27785, 1999.
7. Bowden ET, Earth M, Thomas D, Glazer RI, and Mueller SC. An invasion-related complex of cortactin, paxillin and PKCμ associates with invadopodia at sites of extracellular matrix degradation. Oncogene 18: 4440-4449, 1999.
8. Burgess AW. Growth control mechanisms in normal and transformed intestinal cells. Philos Trans R Soc Lond B Biol Sci 353: 903-909, 1998.
9. Davidson LA, Aymond CM, Jiang YH, Turner ND, Lupton JR, and Chapkin RS. Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer. Carcinogenesis 19: 253-257, 1998.
10. Dieterich S, Herget T, Link G, Böttinger H, Pfizenmaier K, and Johannes FJ. In vitro activation and substrates of recombinant, baculovirus expressed human protein kinase C mu. FEBS Lett 381: 183-187, 1996.
11. Dignass AU and Podolsky DK. Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta. Gastroenterology 105: 1323-1332, 1993.