Variant Philadelphia translocations in chronic myeloid leukaemia can mimic typical blast crisis chromosome abnormalities or classic t(9;22): A report of two cases

British Journal of Haematology

Volumn 113, Issue 2, 2001, Pages 439-442

  Reid, Alistair ^a,b,c,d,e   Gribble, Susan M ^a,b,c,d,e   Huntly, Brian J P ^a,b,c,d,e   Andrews, Kathryn M ^a,b,c,d,e   Campbell, Lynda ^a,b,c,d,e   Grace, Colin D ^a,b,c,d,e   Wood, Marion E ^a,b,c,d,e   Green, Anthony R ^a,b,c,d,e   Nacheva, Ellie P ^a,b,c,d,e  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c ST VINCENT S HOSPITAL   (Australia)

^d Digital Scientific Ltd   (United Kingdom)

^e East Suffolk and North Essex Foundation Trust   (United Kingdom)

Author keywords

Chronic myeloid leukaemia; Cryptic chromosomal rearrangements; Fluorescent in situ hybridization; i(17q) chromosome; Variant Philadelphia translocation

Indexed keywords

HYDROXYUREA; INTERFERON;

AGED; ARTICLE; BLAST CELL CRISIS; BONE MARROW BIOPSY; CASE REPORT; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CHRONIC MYELOID LEUKEMIA; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; KARYOTYPE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL;

AGED; CHROMOSOME BANDING; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 22; CHROMOSOMES, HUMAN, PAIR 9; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; METAPHASE; PHILADELPHIA CHROMOSOME; TRANSLOCATION, GENETIC;

EID: 0034995377     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02778.x     Document Type: Article

References (12)

1. Complex translocations of the Ph chromosome and Ph negative CIVIL arise from similar mechanisms, as evidenced by FISH analysis
2. Cytogenetic and molecular analysis of the Ph translocation in chronic myeloid leukemia
3. Fluorescence in situ hybridization detection of two telomeres on the short arm of a derived chromosome 16 in an infant with thrombocytopenia
4. The cytogenetic scenario of chronic myeloid leukemia
5. Philadelphia-negative chronic myeloid leukaemia: Detection by FISH of BCR-ABL fusion gene localized either to chromosome 9 or chromosome 22
6. A minute chromosome in human granulocytic leukemia
7. Cytogenetics of chronic myelogeneous leukemia
8. Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
9. Improved sensitivity of BCR-ABL detection: A triple-probe three-color fluorescence in situ hybridization system
10. Large deletions at the t (9: 22) breakpoint are common and may identify a poor-prognosis subgroup of patients with chronic myeloid leukemia
11. Clinical implications of fluorescence in situ hybridization analysis in 13 chronic myeloid leukemia cases: Ph-negative and variant Ph-positive