The development of a blend-sampling technique to assess the uniformity of a powder mixture

Drug Development and Industrial Pharmacy

Volumn 27, Issue 4, 2001, Pages 297-307

  Garcia, T P ^a   Wilkinson, S J ^a   Scott, J F ^a  

^a PFIZER INC   (United States)

Author keywords

Blend sampling; Content uniformity; Sampling bias; Static charge

Indexed keywords

DRUG;

ARTICLE; DRUG DOSAGE FORM; DRUG MANUFACTURE; POWDER; SAMPLING; TABLET;

BIAS (EPIDEMIOLOGY); CHEMISTRY, PHARMACEUTICAL; PHARMACEUTICAL PREPARATIONS; POWDERS; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; TABLETS;

EID: 0034995187     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-100103729     Document Type: Article

References (15)

1. Blend uniformity and unit dose sampling
2. Monitoring the mixing of powders
3. The definition and assessment of mixture quality in mixtures of particulate solids
4. Sampling practices in powder blending
5. Errors associated with the thief probe for bulk powder sampling
6. Unit dose sampling - A tale of two thieves
7. Examination of components of variance for a production scale, low dose powder blend and resulting tablets
8. Comparison of the performance of two sample thieves for the determination of the content uniformity of a powder blend
9. Blending validation and content uniformity of low-content, noncohesive powder blend
10. Blend uniformity analysis: Validation and in-process testing
11. Unit dose sampling and blend content uniformity testing
12. Sampling in blending validation
13. Evaluation of blend uniformity: Effect of granulation sample size