Endotracheal tube cuffs filled with lidocaine as a drug delivery system: In vitro and in vivo investigations

European Journal of Pharmaceutical Sciences

Volumn 13, Issue 3, 2001, Pages 319-323

  Dollo, Gilles ^a   Estebe, Jean Pierre ^a,b   Le Corre, Pascal ^a   Chevanne, François ^a   Ecoffey, Claude ^b   Le Verge, Roger ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b Hotel Dieu CHU Rennes   (France)

Author keywords

Endotracheal intubation; Endotracheal tube cuff; In vitro diffusion; Lidocaine; Post operative sore throat

Indexed keywords

BIOLOGICAL ORGANS; DIFFUSION; HYDROPHOBICITY; PATIENT TREATMENT; PHARMACOKINETICS; SURGERY;

TUBE CUFFS;

DRUG PRODUCTS;

LIDOCAINE;

ADULT; ALKALINIZATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG FORMULATION; DRUG UPTAKE; ENDOTRACHEAL CUFF; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; PAIN THRESHOLD; PILOT STUDY; PRIORITY JOURNAL; SORE THROAT; SPINAL ANESTHESIA;

ADULT; ANESTHETICS, LOCAL; DRUG DELIVERY SYSTEMS; HUMANS; INDICATORS AND REAGENTS; INTUBATION, INTRATRACHEAL; LIDOCAINE; MALE; MIDDLE AGED; PHARYNGITIS; PILOT PROJECTS; POSTOPERATIVE COMPLICATIONS; PRONE POSITION; SMOKING;

EID: 0034994595     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(01)00119-1     Document Type: Article

References (12)

1. Evaluation of pressure changes in a new design tracheal tube cuff, the Portex Soft Seal, during nitrous oxide anaesthesia
2. Lidocaine 10% in the endotracheal tube cuff: Blood concentrations, haemodynamic and clinical effects
3. The effects of intracuff lidocaine on endotracheal-tube-induced emergence phenomena after general anesthesia
4. In vitro diffusion of lidocaine across endotracheal tube cuffs
5. Prophylactic lidocaine use preintubation: A review
6. High-performance liquid chromatographic determination of bupivacaine in plasma samples for biopharmaceutical studies and application to seven other local anaesthetics
7. Lidocaine in the endotracheal tube cuff reduces postoperative sore throat
8. Plasma concentrations of lidocaine resulting from lubrication of endotracheal tubes with lidocaine ointment and jelly
9. In vitro diffusion of lidocaine across endotracheal tube cuffs
10. Systemic absorption of lignocaine ointment from tracheal tubes
11. Nitrous oxide increases endotracheal cuff pressure and the incidence of tracheal lesions in anesthetized patients
12. Cuff failure in polyvinyl chloride tracheal tubes sprayed with lignocaine