Molecular mechanisms in lymphocyte activation and growth

Immunologic Research

Volumn 23, Issue 2-3, 2001, Pages 157-166

  Ballard, D W ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gene Expression; Lymphocyte; NF B; Retrovirus; Signal Transduction

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN KINASE; REPRESSOR PROTEIN; T LYMPHOCYTE RECEPTOR; TAX PROTEIN; VIRUS PROTEIN;

ARTICLE; CELL GROWTH; DISEASE ASSOCIATION; GENETIC TRANSFORMATION; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNE RESPONSE; LYMPHOCYTE ACTIVATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; REPRESSOR GENE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION; VIRUS CELL INTERACTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL CYCLE; DNA-BINDING PROTEINS; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GENE PRODUCTS, TAX; HIV; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MACROMOLECULAR SUBSTANCES; MICE; NF-KAPPA B; PROTEIN ENGINEERING; RECEPTORS, INTERLEUKIN-2; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC;

EID: 0034992184     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:23:2-3:157     Document Type: Article

References (58)

1. Contingent genetic regulatory events in T lymphocyte activation
2. Host factors and the pathogenesis of HIV-induced disease
3. Persistent activation of NF-κB by the Tax transforming protein of HTLV-I: Hijacking cellular IκB kinases
4. Human T cell leukemia virus type 1 (HTLV-1) and human diseases
5. Function and activation of NF-κB in the immune system
6. NF-κB and Rel proteins: Evolutionarily conseved mediators of immune responses
7. NF-κB: Ten years after
8. The NF-κB and IκB proteins: New discoveries and insights
9. NF-κB: A family of inducible and differentially expressed enhancer-binding proteins in humanT cells
10. A novel NF-κB complex containing p65 homodimers: Implications for transcriptional control at the level of subunit dimerization
11. The 65-kDa subunit of human NF-κB functions as a potent transcriptional activator and a target for v-Rel-mediated repression
12. The c-rel pro-togene product represses NF-κB p65-mediated transcriptional activation of the long terminal repeat of type 1 human immu-nodeficiency virus
13. Cross-coupling of the NF-κB p65 and Fos/Jun transcription factors produces potentiated biological function
14. Mice lacking the c-rel proto-oncogene exhibit defects in lyhmphocyte proliferation, humoral immunity, and interleukin-2 expression
15. IκB: A specific inhibitor of the NF-κB transcription factor
16. The IκB proteins: Multifunctional regulators of Rel/NF-κB transcription factors
17. Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity
18. IκBβ regulates the persistent response in a biphasic activation of NF-κB
19. IκB/MAD3 masks the nuclear localization signal of NF-κB p65 and requires the trans-activation domain to inhibit NF-κB p65 DNA binding
20. Inactivation of IκBβ by the Tax protein of human T-cell leukemia virus type 1: A potential mechanism for the constitutive induction of NF-κB
21. The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation
22. Phosphorylation of IκBα in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability
23. Casein kinase II phosphorylates IκBα at S-283, S-288, S-293, and T-291 and is required for its degradation
24. Constitutive phosphorylation of IκBα by casein kinase II occurs preferentially at serine 293: Requirement for degradation of free IκBa
25. Basal phosphorylation of the PEST domain in IκBβ regulates its functional interaction with the c-rel proto-oncogene product
26. Phosphorylation of the PEST domain of IκBβ regulates the function of NF-κB/IκBβ complexes
27. Role of unphosphorylated, newly synthesized IκBβ in persistent activation of NF-κB
28. Rel/NF-κB/IκB family: Intimate tales of association and dissociation
29. NF-κB controls expression of inhibitor IκBα: Evidence for an inducible autoregulatory pathway
30. Autoregulation of the NF-κB transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs
31. Promoter analysis of the gene encoding the IκBα/MAD3 inhibitor ofNF-κB: Positive regulation by members of the rel/NF-κB family
32. Coupling of a signal-response domain in IκBα to multiple pathways for NF-κB activation
33. Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation
34. Phosphorylation of human IκB-α on serines 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli
35. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation
36. Bridging the gap: Composition, regulation, and physiological function of the IκB kinase complex
37. Ubiquitin and the proteasome are required for processing the NF-κB1 precursor and the activation of NF-κB
38. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway
39. Signal-induced degradation of IκBα requires site-specific ubiquitination
40. Identification of the receptor component of the IκBα-ubiquitin ligase
41. Corepression of RelA and c-Rel inhibits immunoglobulin kappa gene transcription and rearrangement in precursor B lymphocytes
42. An intact NF-κB signaling pathway is required for maintenance of mature B cell subsets
43. Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival
44. Transcription factor NF-κB regulates inducible Oct-2 gene expression in precursor B lymphocytes
45. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of NF-κB
46. Control of apoptosis by Rel/NF-κB transcription factors
47. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control
48. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
49. IAP family proteins-suppressors of apoptosis
50. HIV-1, HTLV-1, and normal T-cell growth: Transcriptional strategies and surprises
51. HTLV-I Tax induces cellular proteins that activate the κB element in the IL-2 receptor α gene
52. HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor
53. Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-1 tax gene product
54. Ablation of transplanted HTLV-1 Tax-transformed tumors in mice by antisense inhibition of NF-κB
55. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation
56. The Tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IκB kinases containing IKKα and IKKβ
57. IKKγ mediates the interaction of cellular IκB kinases with the Tax transforming protein of human T-cell leukemia virus type 1
58. Persistent activation of NF-κB by the Tax transforming protein involves chronic phosphorylation of IκB kinase subunits IKKα and IKKβ