Prevention of experimental autoimmune encephalomyelitis by encephalitogenic epitope sequence simplified derivatives

Molecular Immunology

Volumn 37, Issue 16, 2000, Pages 951-960

  Marino, Maria ^a   Ippolito, Agostino ^a   Ruvo, Menotti ^a   Scarallo, Angela ^a   Volpe, Silvestro ^b   Fassina, Giorgio ^a  

^a Tecnogen SpA   (Italy)

^b S G MOSCATI HOSPITAL   (Italy)

Author keywords

Multiple sclerosis; Prevention; Simplified peptides

Indexed keywords

ENCEPHALITOGENIC PROTEIN; EPITOPE; GLYCINE; MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELL SURFACE; CONCENTRATION RESPONSE; CONTROLLED STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN BINDING; T LYMPHOCYTE;

ANIMALIA; MURINAE;

EID: 0034991927     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(01)00016-5     Document Type: Article

References (38)

1. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells
2. 1
3. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
4. Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis
5. Three-dimensional structure of a peptide extending from one end of a class I MHC binding site
6. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor
7. The minimal number of class II MHC-antigen complexes needed for T cell activation
8. Monoclonal antibodies to ThB detect close linkage of Ly-6 and a gene regulating ThB expression
9. Antagonism of superantigen-stimulated helper T-cell clones and hybridomas by altered peptide ligand
10. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
11. T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis
12. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex
13. Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy
14. Minimum structural requirements for peptide presentation by major histocompatibility complex class II molecules: Implications in induction of autoimmunity
15. Essential flexibility in the T-cell recognition of antigen
16. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T cell stimulation
17. Identification of self peptides bound to purified HLA-B27
18. Antigen-reactive T cell clones. I. Transcomplementing hybrid I-A-region gene products function effectively in antigen presentation
19. The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation
20. ζ Phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
21. Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules
22. Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins
23. Unique T cell antagonist properties of the exact self-correlate of a peptide antigen revealed by self-substitution of non-self-positions in the peptide sequence
24. A cell culture model for T lymphocyte clonal anergy
25. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
26. Partial T cell signalling: Altered phospho-ζ and lack of Zap 70 recruitment in APL-induced T cell anergy
27. A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis
28. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
29. Serial triggering of many T-cell receptors by a few peptide-MHC complexes
30. b molecule
31. Topological mimicry of cross-reacting enantiomeric peptide antigens
32. Specific T-cell tolerance may reflect selective activation of lymphokine synthesis
33. Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: More than blocking alone
34. Inhibition of experimental autoimmune encephalomyelitis by MHC class II binding competitor peptides depends on the relative MHC binding affinity of the disease-inducing peptide
35. T cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination
36. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis
37. Multiple discrete encephalitogenic epitopes of the autoantigen myelin basic protein include a determinant for I-E class II-restricted T cells