Novel in vitro assays for assessing the haemorrhagic activity of snake venoms and for demonstration of venom metalloproteinase inhibitors

Toxicon

Volumn 39, Issue 9, 2001, Pages 1429-1434

  Bee, A ^a   Theakston, R D G ^b   Harrison, R A ^b   Carter, S D ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Gelatinase; In vitro haemorrhagic assay; MP inhibitors; Venom

Indexed keywords

EDETIC ACID; METALLOPROTEINASE INHIBITOR; SNAKE VENOM;

ARTICLE; BLEEDING; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEASIBILITY STUDY; HUMAN; IN VITRO STUDY; NEUROTOXICITY; PRIORITY JOURNAL; SCREENING; TOXICITY TESTING; ZYMOGRAPHY;

ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GELATIN; HEMORRHAGE; METALLOENDOPEPTIDASES; PROTEASE INHIBITORS; SNAKE VENOMS;

ANIMALIA; ELAPIDAE; SERPENTES; VIPERIDAE;

EID: 0034991822     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(01)00103-9     Document Type: Article

References (16)

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3. Matrix metalloproteinases; a review
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5. Matrix metalloproteinases 2 and 9 in equine synovial fluids
6. Factor X-activating glycoprotein of Russell's viper venom. Polypeptide composition and characterization of the carbohydrate moieties
7. Secretion of metalloproteinases by stimulated capillary endothelial cells
8. CDNA sequences for four snake venom metalloproteinases: Structure, classification, and their relationship to mammalian reproductive proteins
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14. The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis
15. Development of simple standard assay procedures for the characterization of snake venoms
16. Treatment of snake bites by Bothrops species and Lachesis muta in Ecuador: Laboratory screening of candidate antivenoms