Rearrangement in the coding region of the MYCN gene in a subset of amplicons in a case of neuroblastoma with MYCN amplification

Diagnostic Molecular Pathology

Volumn 10, Issue 2, 2001, Pages 100-104

  Chen, Beiyun ^a   Jhanwar, Suresh C ^a   Ladanyi, Marc ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Amplification; MYCN gene; Neuroblastoma; Rearrangement

Indexed keywords

DNA;

ARTICLE; CASE REPORT; CHILD; DNA SEQUENCE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; MALE; NEUROBLASTOMA; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOMATIC CELL; SOUTHERN BLOTTING;

ABDOMINAL NEOPLASMS; BASE SEQUENCE; BLOTTING, SOUTHERN; CHILD, PRESCHOOL; CHROMOSOME FRAGILITY; COMBINED MODALITY THERAPY; DNA, NEOPLASM; FATAL OUTCOME; GENE AMPLIFICATION; GENE REARRANGEMENT; GENES, MYC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; POLYMERASE CHAIN REACTION;

EID: 0034991595     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-200106000-00005     Document Type: Article

References (12)

1. Megabase-scale analysis of the origin of MYCN amplicons in human neuroblastomas
2. Molecular basis for heterogeneity in human neuroblastoma
3. Amplification of MYCN in untreated human neuroblastomas correlates with advanced disease stage
4. Neuroblastoma with DNA amplification and rearrangement in the MYCN gene region
5. Characterization of DNA rearrangements of MYCN gene amplification in three neuroblastoma cell lines by pulsed-field gel electrophoresis
6. Transposition and amplification of oncogene-related sequences in human neuroblastomas
7. Molecular biology of neuroblastoma
8. High-resolution mapping of a 130-kb core region of the MYCN amplicon in neuroblastomas
9. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumor
10. Amplification of MYCN as a prognostic marker for patients with neuroblastoma
11. Amplification and rearrangement of DNA sequences from the chromosomal region 2p24 in human neuroblastomas
12. Nucleotide sequence of the human MYCN gene