Peripheral link model as an alternative for pharmacokinetic-pharmacodynamic modeling of drugs having a very short elimination half-life

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 28, Issue 1, 2001, Pages 7-25

  Laurin, J ^a   Donati, F ^a   Nekka, F ^a   Varin, F ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Anesthetized patients; Mivacurium; Neuromuscular blocking drugs; Peripheral elimination; Peripheral link model; Pharmacokinetic pharmacodynamic modeling

Indexed keywords

ATRACURIUM; CHOLINESTERASE; DOXACURIUM; MIVACURIUM; NEUROMUSCULAR BLOCKING AGENT;

ADULT; ANESTHESIA; ARTICLE; CLINICAL ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; HUMAN; MALE; PHARMACODYNAMICS; PLASMA CLEARANCE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ANESTHESIA; ATRACURIUM; BODY FLUID COMPARTMENTS; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HALF-LIFE; HUMANS; ISOQUINOLINES; MATHEMATICAL COMPUTING; MODELS, BIOLOGICAL; NEUROMUSCULAR NONDEPOLARIZING AGENTS;

EID: 0034991417     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011513618081     Document Type: Article

References (21)

1. Multicompartment pharmacokinetic models and pharmacological effects
2. Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine
3. Simultaneous pharmacokinetic and pharmacodynamic modeling
4. Elimination of atracurium in humans: Contribution of Hofmann elimination and ester hydrolysis vs. organ-based elimination
5. Assuming peripheral elimination: Its impact on the estimation of pharmacokinetic parameters of muscle relaxants
6. Pharmacokinetics of mivacurium isomers and their metabolites in healthy volunteers after intravenous bolus administration
7. Pharmacokinetics and pharmacodynamics of atracurium with and without previous suxamethonium administration
8. Pharmacokinetic-pharmacodynamic modeling of doxacurium: Effect of input rate
9. Autonomic and neuromuscular effects of mivacurium and its isomers in cats
10. The pharmacokinetics and pharmacodynamics of the stereoisomers of mivacurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia
11. Pharmacokinetics of mivacurium in normal patients and those with hepatic or renal failure
12. Acetylcholinesterase and butyryl-cholinesterase are expressed in the spinal meninges of monkeys and pigs
13. Pharmacokinetics and pharmacodynamics of doxacurium in young and elderly patients during isoflurane anesthesia
14. High-performance liquid chromatographic assays with fluorometric detection for mivacurium isomers and their metabolites in human plasma
15. Determination of atracurium and laudanosine in human plasma by high-performance liquid chromatography
16. Influence of aging on the pharmacokinetics and pharmacodynamics of doxacurium
17. Monitoring of neuromuscular function
18. Kinetics of pharmacologic response
19. Understanding the dose-effect relationship: Clinical application of pharmacokinetic-pharmacodynamic models
20. Pharmacokinetics and pharmacodynamics of cisatracurium after a short infusion in patients under propofol anesthesia