Genetic deletions of NCAM and PSA impair circadian function in the mouse

Physiology and Behavior

Volumn 73, Issue 1-2, 2001, Pages 185-193

  Shen, Huaming ^a   Watanabe, Michiko ^a   Tomasiewicz, Henry ^a,b   Glass, J David ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KENT STATE UNIVERSITY   (United States)

Author keywords

Circadian rhythm; Mouse; Mutation; NCAM; Polysialic acid; PSA NCAM; SCN

Indexed keywords

ISOPROTEIN; NERVE CELL ADHESION MOLECULE; POLYSIALIC ACID;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; GENE DELETION; GENOTYPE; LOCOMOTION; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRAIN DIFFERENCE; TRANSGENIC MOUSE;

ANIMALS; CHROMOSOME DELETION; CIRCADIAN RHYTHM; GENOTYPE; MICE; MICE, MUTANT STRAINS; MOTOR ACTIVITY; NEURAL CELL ADHESION MOLECULES; SIALIC ACIDS; SUPRACHIASMATIC NUCLEUS;

EID: 0034988588     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(01)00468-1     Document Type: Article

References (54)

1. NCAM polysialic acid can regulate both cell-cell and cell-substrate interactions
2. The polysialic acid modification of the neural cell adhesion molecule is involved in spatial learning and hippocampal long-term potentiation
3. Molecular mechanisms of axon growth and guidance
4. Mapping of the distribution of polysialylated neural cell adhesion molecule throughout the central nervous system of the adult rat: An immunohistochemical study
5. Alterations in neural cell adhesion molecules during development of different regions of the nervous system
6. A heparin-binding domain from N-CAM is involved in neural cell-substratum adhesion
7. Neuronal cell-cell adhesion depends on interactions of N-CAM with heparin-like molecules
8. Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning
9. Long-term but not short-term plasticity at mossy fiber synapses is impaired in neural cell adhesion molecule-deficient mice
10. PSA-NCAM: An important regulator of hippocampal plasticity
11. A threshold effect of the major isoforms of NCAM on neurite outgrowth
12. 2+ channels
13. Alternative splicing of the cytoplasmic domain of neural cell adhesion molecule alters its ability to act as a substrate for neurite outgrowth
14. Strain differences of the mouse's free-running circadian rhythm in continuous darkness
15. Gene-targeting studies of mammalian behavior: Is it the mutation or the background genotype?
16. Expression of immunoreactive polysialylated neural cell adhesion molecule in the suprachiasmatic nucleus
17. Polysialylated neural cell adhesion molecule modulates photic signaling in the mouse suprachiasmatic nucleus
18. The role of polysialic acid in migration of olfactory bulb interneuron precursors in the subventricular zone
19. Localization of a suprachiasmatic nucleus subregion regulating locomotor activity
20. Neurophysiology of the suprachiasmatic circadian pacemaker in rodents
21. Intracellular location, temporal expression, and polysialylation of neural cell adhesion molecule in astrocytes in primary culture
22. Retention of J1/tenascin and the polysialyated form of the neural cell adhesion molecule (NCAM) in the adult olfactory bulb
23. Organization and function of a central nervous system oscillator: The suprachiasmatic nucleus
24. PSA-NCAM is required for activity-induced synaptic plasticity
25. The ontogeny of luteinizing hormone-releasing hormone (LHRH) producing neurons in the chick embryo: Possible evidence for migrating LHRH neurons from the olfactory epithelium expressing a highly polysialylated neural cell adhesion molecule
26. Alternatively spliced mRNAs code for different polypeptide chains of the chicken neural cell adhesion molecule (N-CAM)
27. Modulation of NCAM polysialylation is associated with morphofunctional modifications in the hypothalamo-neurohypophysial system during lactation
28. The 180-kD component of the neural cell adhesion molecule N-CAM is involved in cell-cell contacts and cytoskeleton-membrane interactions
29. Expression of the neural cell adhesion molecule and polysialic acid during early mouse embryogenesis
30. Polysialylation as a regulator of neural plasticity in rodent learning and aging
31. The neural cell adhesion molecule in synaptic plasticity and ageing
32. Circadian activity rhythms in BALB/c mice: A weakly-coupled circadian system?
33. Neural regulation of circadian rhythms
34. Binding properties of a cell adhesion molecule from neural tissue
35. Polysialic acid in the vertebrate nervous system: A promoter of plasticity in cell-cell interactions
36. Increase in proportion of hippocampal spine synapses expressing neural cell adhesion molecule NCAM 180 following long-term potentiation
37. Circadian time keeping in BALB/c and C57BL/6 inbred mouse strains
38. Highly polysialyated neural cell adhesion molecule (NCAM-H) is expressed by newly generated granule cells in the dentate gyrus of the adult rat
39. Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system
40. Temporal and spacial relationships between PSA-NCAM-expressing, newly generated granule cells, and radial glia-like cells in the adult dentate gyrus
41. Ultrastructural analysis of polysialylated neural cell adhesion molecule in the suprachiasmatic nuclei of the adult mouse
42. Role of neural cell adhesion molecule and polysialic acid in mouse circadian clock function
43. NCAM expression by subsets of taste cells is dependent upon innervation
44. A role for polysialic acid in neural cell adhesion molecule heterophilic binding to proteoglycans
45. Cell surface expression of polysialic acid on NCAM is a prerequisite for activity-dependent morphological neuronal and glial plasticity
46. Neuronal-glial and synaptic plasticity in the adult rat paraventricular nucleus
47. Activity-dependent neuronal-glial and synaptic plasticity in the adult mammalian hypothalamus
48. Retension of embryonic features by an adult neuronal system capable of plasticity: Polysialylated neural cell adhesion molecule in the hypothalamo-neurohypophysial system
49. Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system
50. Synaptogenesis and ultrastructural localization of the polysialylated neural cell adhesion molecule in the developing striatum
51. Generation of multiple N-CAM polypeptides from a single gene
52. Neural cell adhesion molecules of the immunoglobulin superfamily: Role in axon growth and guidance
53. Cell signaling and CAM-mediated neurite outgrowth
54. Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms