Synthesis of hydropobic N′-mono and N′,N″-double alkylated eremomycins inhibiting the transglycosylation stage of bacterial cell wall biosynthesis

Journal of Antibiotics

Volumn 54, Issue 5, 2001, Pages 455-459

  Pavlov, A Y ^a   Miroshnikova, O V ^a   Printsevskaya, S S ^a   Olsufyeva, E N ^a   Preobrazhenskaya, M N ^a   Goldman, R C ^a   Branstrom, A A ^a   Baizman, E R ^a   Longley, C B ^a  

^a GAUSE INSTITUTE OF NEW ANTIBIOTICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRO ALANINE DEXTRO ALANINE LIGASE; EREMOMYCIN; EREMOMYCIN DERIVATIVE; PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; VANCOMYCIN; VANCOMYCIN DERIVATIVE; ANTIINFECTIVE AGENT; GLYCOPEPTIDE;

ALKYLATION; AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL CELL WALL; BIOCHEMISTRY; BIOSYNTHESIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS; GLYCOSYLATION; HYDROPHOBICITY; IN VITRO STUDY; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; CELL WALL; COMPARATIVE STUDY; DRUG EFFECT; METABOLISM; MICROBIOLOGICAL EXAMINATION; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY; SYNTHESIS;

ALKYLATION; ANTI-BACTERIAL AGENTS; CELL WALL; DRUG RESISTANCE, MICROBIAL; ENTEROCOCCUS; GLYCOPEPTIDES; GLYCOSYLATION; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES; VANCOMYCIN;

EID: 0034987305     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.54.455     Document Type: Article

References (12)

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2. Chemical modification of glycopeptide antibiotics
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4. Structure-activity relationships in the series of eremomycin carboxamides
5. Common factors in the mode of action of vancomycin group antibiotics active against resistant bacteria
6. The role of hydrophobic side chains as determinants of antibacterial activity of semisynthetic glycopeptide antibiotics
7. Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala
8. Chlorobiphenyl-desleucyl-vancomycin inhibits the transglycosylation process required for peptidoglycan synthesis in bacteria
9. The role of hydrophobic substituents in the biological activity of glycopeptide antibiotics
10. Reductive alkylation of glycopeptide antibiotics: Synthesis and antibacterial activity
11. Synthesis and biological activity of derivatives of glycopeptide antibiotics eremomycin and vancomycin nitrosated, acylated or carbamoylated at the N-terminal
12. Enzymatic deacylation of teicoplanin followed by reductive alkylation: Synthesis and antibacterial activity of new glycopeptides