Bile acid sequestrants based on cationic dextran hydrogel microspheres. 2. Influence of the length of alkyl substituents at the amino groups of the sorbents on the sorption of bile salts

Journal of Pharmaceutical Sciences

Volumn 90, Issue 6, 2001, Pages 681-689

  Nichifor, Marieta ^a,b   Zhu, X X ^b   Baille, Wilms ^b   Cristea, Doina ^a   Carpov, Adrian ^a  

^a PETRU PONI INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Romania)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Bile acids; Dextran polymers; Hydrophobic interactions; Hypercholesterolemia; Quaternary ammonium groups

Indexed keywords

ALKYL GROUP; AMMONIA; BILE ACID; BILE SALT; BUFFER; CHOLIC ACID; COLESTYRAMINE; DEOXYCHOLIC ACID; DEXTRAN; GLYCOCHOLIC ACID; MICROSPHERE; POLYMER; TAUROCHOLIC ACID;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEL; HYDROPHOBICITY; IN VITRO STUDY; IONIZATION; STOICHIOMETRY;

EID: 0034986791     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1024     Document Type: Article

References (27)

1. Interruption of the enterohepatic circulation of bile acid in man: Comparative effects of cholestyramine and ileal exclusion on cholesterol Metabolism
2. Effect of Cholestyramine on bile acid metabolism in normal man
3. Bile acid sequestrants
4. Beneficial effects of combined colestipol-niacin therapy on coronary venous bypass grafts
5. The lipid research clinics coronary primary prevention trial results: II. The relationship in reduction of incidence of coronary heart disease to cholesterol lowering
6. Bile acid sequestrant therapy
7. Quantification of the binding tendencies of cholestyramine I: Effect of structure and added electrolyte on the binding of unconjugated and conjugated bile-salt anions
8. In vitro binding of mixed micellar solutions of fatty acids and bile salts by cholestyramine
9. Effect of cholestyramine particle size on in vitro binding of conjugated bile salts
10. In vitro studies to investigate the reason for the low potency of cholestyramine and colestipol
11. Lipid lowering drugs: An overview of indications and optimum therapeutic use
12. Synthesis and pharmacological action of some cholestyramine analogs
13. Quaternized colestipol, an improved bile salt adsorbent: In vitro studies
14. Modification of chitosan to improve its hypocholesterolemic capacity
15. In vitro bile acid binding on aminated microcrystalline cellulose
16. Aminated polysaccharides as bile acid sorbents: In vitro study
17. Bile acid sequestrants based on cationic dextran hydrogel microspheres. 1. Influence of the chemical structure of functional groups on the sodium cholate sorption
18. Properties of ion exchange resins in relation to their structure. Part IV. Swelling and shrinkage of sulphonated polystyrene of different cross-linking
19. A simple HPLC method for the analysis of bile acids
20. Interaction of sodium decyl sulfate with poly(-ornithine) and poly(-lysine) in aqueous solutions
21. Theoretical analysis of the crosslinking effect on the polyelectrolyte-surfactant interaction
22. DMP 504, a novel hydrogel bile acid sequestrant: I. Equilibrium binding properties and computer simulation of human bile flow
23. Effect of hydrophobic interaction on the cooperative binding of a surfactant to a polymer network
24. SK&F 97426 - A more potent bile acid sequestrant and hypocholesterolaemic agent than cholestyramine in hamster
25. Effect of hypolipidemic drugs on bile acid metabolism in man
26. The bile acids. Chemistry