Immune evasion genes from filarial nematodes

International Journal for Parasitology

Volumn 31, Issue 9, 2001, Pages 889-898

  Maizels, Rick M ^a   Gomez Escobar, Natalia ^a   Gregory, William F ^a   Murray, Janice ^a   Zang, Xingxing ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cystatin; Cytokine; Helminth; Serpin; Vaccine

Indexed keywords

ANTIGEN; ASPARIGINYL ENDOPEPTIDASE; CYSTATIN; CYSTEINE PROTEINASE; MACROPHAGE MIGRATION INHIBITION FACTOR; PAPAIN; PROTEINASE; SERINE PROTEINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; B LYMPHOCYTE; BRUGIA MALAYI; CELL SURFACE; CONFERENCE PAPER; ENZYME ACTIVITY; FILARIASIS; GENE EXPRESSION; GENOME; HOST PARASITE INTERACTION; IMMUNE RESPONSE; INTERMETHOD COMPARISON; MULTIGENE FAMILY; NONHUMAN; PROTEIN SECRETION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; T LYMPHOCYTE;

ANIMALS; ANTIGENS, HELMINTH; BRUGIA MALAYI; CYSTATINS; CYTOKINES; FILARIASIS; GENE EXPRESSION REGULATION; GENES, HELMINTH; HUMANS; SERPINS;

ANCYLOSTOMATOIDEA; BRUGIA MALAYI; MAMMALIA; METAZOA; NEMATODA; VERMES;

EID: 0034981964     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(01)00213-2     Document Type: Conference Paper

References (74)

1. Cystatins
2. Profound suppression of cellular proliferation mediated by the secretions of nematodes
3. Immunology of human helminth infection
4. Antigen presenting cells from mice harboring the filarial nematode. Brugia malayi, prevent cellular proliferaton but not cytokine production
5. Analysis of genes expressed at the infective larval stage validate the utility of Litomosoides sigmodontis as a murine model for filarial vaccine development
6. Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site
7. The cystatins: A new class of peptidase inhibitors
8. Understanding chronic nematode infections: Evolutionary considerations, current hypotheses and the way forward
9. Ancylostoma secreted protein 1 (ASP-1) homologues in human hookworms
10. Nematode spliced leaders-ubiquity, evolution and utility
11. Genes and genomes of Necator americanus and related hookworms
12. Identification of the major soluble cuticular protein of lymphatic filarial nematode parasites (gp29) as a secretory homolog of glutathione peroxidase
13. How much human helminthiasis is there in the world?
14. A survey of genes expressed in adults of the human hookworm Necator americanus
15. A divergent member of the transforming growth factor β receptor family from Schistosoma mansoni is expressed on the parasite surface membrane
16. A phosphorylcholine-containing filarial nematode-secreted product disrupts B lymphocyte activation by targeting key proliferative signaling pathways
17. Metabolic labeling of Dirofilaria immitis third- and fourth-stage larvae and their excretory-secretory products
18. Purification and characterization of three larval excretory-secretory proteins of Dirofilaria immitis
19. Molecular cloning of a developmentally regulated protein isolated from excretory-secretory products of larval Dirofilaria immitis
20. An abundant, trans-spliced mRNA from Toxocara canis infective larvae encodes a 26 kDa protein with homology to phosphatidylethanolamine binding proteins
21. Vaccination with alum-precipitated recombinant Ancylostoma-secreted protein 1 protects mice against challenge infections with infective hookworm (Ancylostoma caninum) larvae
22. A member of the TGF-β receptor gene family in the parasitic nematode Brugia
23. A novel member of the transforming growth factor-β (TGF-β) superfamily from the filarial nematodes Brugia malayi and B. pahangi
24. Identification of Bm-tgh-2, a filarial nematode homolog of C. elegans daf-7 and human TGF-β, expressed in microfilarial and adult stages of Brugia malayi
25. Differentially expressed, abundant trans-spliced cDNAs from larval Brugia malayi, Mol
26. The abundant larval transcript 1/2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis
27. Induction of signalling energy via the T-cell receptor in cultured Jurkat T cells by pre-exposure to a filarial nematode secreted product
28. Cloning and characterization of Ancylostoma-secreted protein. A novel protein associated with the transition to parasitism by infective hookworm larvae
29. Ancylostoma secreted protein 2: Cloning and characterization of a second member of a family of nematode secreted proteins from Ancylostoma caninum
30. Antifilarial cellular responses detected in a Haitian pediatric population by use of a microblastogenesis assay
31. IgG antibody subclasses in human filariasis. Differential subclass recognition of parasite antigens correlates with different clinical manifestations of infection
32. Characterization of an Onchocerca volvulus L3-specific larval antigen Ov-ALT-1
33. The gp15/400 polyprotein antigen of Brugia malayi binds fatty acids and retinoids
34. Immunologic tolerance in lymphatic filariasis. Diminished parasite-specific T and B cell lymphocyte precursor frequency in the microfilaremic state
35. Phosphocholine-containing antigens of Brugia malayi nonspecifically supress lymphocyte function
36. Adult and microfilarial stages of the filarial parasite Brugia malayi stimulate contrasting cytokine and immunoglobulin isotype responses in BALB/c mice
37. Antigen presenting cells recruited by Brugia malayi induce Th2 differentiation of naïve CD4 + T cells
38. Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell to cell contact
39. Helminth C-type lectins and host-parasite interactions
40. A novel C-type lectin secreted by a tissue-dwelling parasitic nematode
41. Requirement for in vivo production of IL-4, but not IL-10, in the induction of proliferative suppression by filarial parasites
42. Immunological tolerance: The key feature in human filariasis?
43. Phosphorylcholine-bearing antigens in filarial nematode parasites: Analysis of somatic extracts and in vitro secretions of Brugia malayi and B.pahangi and infection sera
44. Filarial surface antigens: The major 29 000 mol.wt. glycoprotein and a novel 17 000-200 000 mol.wt. complex from adult Brugia malayi parasites
45. Immunological modulation and evasion by helminth parasites in human populations
46. T cell activation and the balance of antibody isotypes in human filariasis
47. Vaccination against helminth parasites: The ultimate challenge for immunologists?
48. Immunology of Lymphatic Filariasis
49. An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation
50. CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing
51. The TGF-β family and its composite receptors
52. Re-assessing the global prevalence and distribution of lymphatic filariasis
53. A hookworm glycoprotein that inhibits neutrophil function is a ligand of the integrin CD11b/CD18
54. Infection and disease in lymphatic filariasis: An immunological perspective
55. Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor
56. Immune responses in human infections with Brugia malayi. Specific cellular unresponsiveness to filarial antigens
57. Lymphatic Filariasis. Immunpathogenetic aspects of disease induced by helminth parasites
58. A tissue specific approach for analysis of membrane and secreted protein antigens from Haemonchus contortus gut and its application to diverse nematode species
59. Depression of antigen-specific interleukin-5 and interferon-γ responses in human lymphatic filariasis as a function of clinical status and age
60. Molecular characterization and expression of two putative protective excretory secretory proteins of Haemonchus contortus
61. Modulation of cellular and humoral immunity, and disease manifestation during onset of patency in Brugia pahangi-infected dogs
62. Lymphatic-dwelling filariae
63. Hookworm burden reductions in BALB/c mice vaccinated with recombinant Ancylostoma secreted proteins (ASPs) from Ancylostoma duodenale
64. Brugia malayi: Resistance of cuticular lipids to oxidant-induced damage and detection of α-tocopherol in the neutral lipid fraction
65. Extracellular and cytoplasmic CuZn superoxide dismutases from Brugia lymphatic filarial nematode parasites
66. Brugia pahangi: The cuticular glutathione peroxidase (gp29) protects heterologous membranes from lipid peroxidation
67. Angiogenic activity of Onchocerca volvulus recombinant proteins similar to vespid venom antigen 5
68. Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of ASP-1
69. Identification of abundantly-expressed novel and conserved genes from infective stage larvae of Toxocara canis by an expressed sequence tag strategy
70. Serpins in the Caenorhabditis elegans genome
71. T cell responsiveness correlates differentially with antibody isotype levels in clinical and asymptomatic filariasis
72. Serine proteinase inhibitors from nematodes and the arms race between host and pathogen
73. A novel serpin expressed by the blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases
74. The serpin secreted by Brugia malayi microfilariae Bm-SPN-2, elicits strong, but short-lived, immune responses in mice and humans